AZ 10606120 dihydrochloride

  ( 14 citations )    
Product Datasheet
Catalog Number:3323
Chemical Name:N-[2-[[2-[(2-Hydroxyethyl)amino]ethyl]amino]-5-quinolinyl]-2-tricyclo[3.3.1.13,7]dec-1-ylacetamide dihydrochloride
Product Details
Citations (14)
Supplemental Products
Reviews
Biological Activity
Potent P2X7 receptor antagonist (KD values are 1.4 and 19 nM at human and rat P2X7 receptors respectively). Binds in a positive cooperative manner to sites distinct from, but coupled to, the ATP binding site and acts as a negative allosteric modulator. Inhibits tumor growth and displays antiangiogenic effects in mice.
Technical Data
  • M.Wt:
    495.48
  • Formula:
    C25H34N4O2.2HCl
  • Solubility:
    Soluble to 25 mM in water and to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Desiccate at RT
  • CAS No:
    607378-18-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from AstraZeneca
Product Datasheets
COA view current batch
or select another batch:
Citations:

The citations listed below are publications that use Tocris products. Selected citations for AZ 10606120 dihydrochloride include:

14 Citations: Showing 1 - 10
Filter your results:

  1. Unique residues in the ATP gated human P2X7 receptor define a novel allosteric binding pocket for the selective antagonist AZ10606120
    Authors: Allsopp
    Sci Rep  2017;7(1)
  2. Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP.
    Authors: Karmakar Et al.
    Nat.Commun.  2016;7:10555
  3. Active Caspase-1 Induces Plasma Membrane Pores That Precede Pyroptotic Lysis and Are Blocked by Lanthanides
    Authors: Russo Et al.
    The Journal of Immunology  2016;197:1353
  4. Selected ginsenosides of the protopanaxdiol series are novel positive allosteric modulators of P2X7 receptors.
    Authors: Helliwell Et al.
    Br J Pharmacol  2015;172:3326
  5. The P2X7 receptor regulates cell survival, migration and invasion of pancreatic ductal adenocarcinoma cells.
    Authors: Giannuzzo Et al.
    Purinergic Signal  2015;14:203
  6. Bile acid effects are mediated by ATP release and purinergic signalling in exocrine pancreatic cells.
    Authors: Kowal Et al.
    Mol Cancer  2015;13:28
  7. Probenecid blocks human P2X7 receptor-induced dye uptake via a pannexin-1 independent mechanism.
    Authors: Bhaskaracharya Et al.
    PLoS One  2014;9:e93058
  8. IKKα negatively regulates ASC-dependent inflammasome activation.
    Authors: Martin Et al.
    Nat Commun  2014;5:4977
  9. Tanshinone II A sulfonate, but not tanshinone II A, acts as potent negative allosteric modulator of the human purinergic receptor P2X7.
    Authors: Kaiser Et al.
    J Pharmacol Exp Ther  2014;350:531
  10. Natural compounds with P2X7 receptor-modulating properties.
    Authors: Fischer Et al.
    Purinergic Signal  2013;10:313
  11. P2X7 receptor activation mediates organic cation uptake into human myeloid leukaemic KG-1 cells.
    Authors: Gadeock Et al.
    Mol Biol Cell  2012;8:669
  12. Positive allosteric modulation by ivermectin of human but not murine P2X7 receptors.
    Authors: Nörenberg Et al.
    Br J Pharmacol  2012;167:48
  13. K+ depolarization evokes ATP, adenosine and glutamate release from glia in rat hippocampus: a microelectrode biosensor study.
    Authors: Heinrich Et al.
    Br J Pharmacol  2012;167:1003
  14. Lack of neuroprotection in the absence of P2X7 receptors in toxin-induced animal models of Parkinson's disease.
    Authors: Hracskó Et al.
    Mol Neurodegener  2011;6:28
Expand to show all Citations

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Have you used AZ 10606120 dihydrochloride?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Contact Us to Order
reload

Feedback

Customer Information
Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee