Chemical Name:N-[2-[[2-[(2-Hydroxyethyl)amino]ethyl]amino]-5-quinolinyl]-2-tricyclo[22.214.171.124,7]dec-1-ylacetamide dihydrochloride
Biological Activity Potent P2X7 receptor antagonist (KD values are 1.4 and 19 nM at human and rat P2X7 receptors respectively). Binds in a positive cooperative manner to sites distinct from, but coupled to, the ATP binding site and acts as a negative allosteric modulator. Inhibits tumor growth and displays antiangiogenic effects in mice.
Soluble to 25 mM in water and to 100 mM in DMSO
Desiccate at RT
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