AZ 10606120 dihydrochloride

Key Product Details

Product Description

AZ 10606120 dihydrochloride is a potent P2X₇ receptor antagonist (K_D values are 1.4 and 19 nM at human and rat P2X₇ receptors respectively). Binds in a positive cooperative manner to sites distinct from, but coupled to, the ATP binding site and acts as a negative allosteric modulator. Inhibits tumor growth and displays antiangiogenic effects in mice.

Licensing Information

Sold for research purposes under agreement from AstraZeneca

Product Specifications for AZ 10606120 dihydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for AZ 10606120 dihydrochloride

The following data is based on the product molecular weight 495.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.02 mL	10.09 mL	20.18 mL
5 mM	0.40 mL	2.02 mL	4.04 mL
10 mM	0.20 mL	1.01 mL	2.02 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 15 publications citing the usage of this product.

• Adinolfi Expression of P2X7 receptor increases in vivo tumor growth. Cancer Res. 2012 PMID: 22505653
• Michel and Fonfria Agonist potency at P2X₇ receptors is modulated by structurally diverse lipids. Br.J.Pharmacol. 2007 PMID: 17700717
• Michel Negative and positive allosteric modulators of the P2X₇ receptor. Br.J.Pharmacol. 2008 PMID: 18071294
• Michel Direct labelling of the human P2X₇ receptor and identification of positive and negative cooperativity of binding. Br.J.Pharmacol. 2007 PMID: 17339830

Product Documents for AZ 10606120 dihydrochloride