Azurocidin/CAP37/HBP Antibody (z6718)

Novus Biologicals | Catalog # NBP3-11297

Novus Biologicals
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry-Frozen, Western Blot, Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # z6718
View all Azurocidin/CAP37/HBP Primary Antibodies »

Product Specifications

Immunogen

The monoclonal antibody z6718 recognizes azurocidin.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Applications for Azurocidin/CAP37/HBP Antibody (z6718)

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Frozen

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
For Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Frozen sections and Western blotting, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

0.2 um filtered solution in PBS, 0.1% BSA

Preservative

0.02% Sodium Azide

Concentration

0.1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: Azurocidin/CAP37/HBP

The monoclonal antibody z6718 recognizes azurocidin (also called heparin-binding protein (HBP) or cationic antimicrobial protein of 37 Kda (CAP37). Azurocidin is an inactive homolog of serine proteinases residing in granulocytes. Initially it was thought to have only activity against gram-negative bacteria. Later it was also found to act against gram-positive bacteria and C.albicans. Azurocidin is considered a family member of polymorphonuclear leukocytes- derived antimicrobial proteins like defensins, LL-37 and lysozyme. Azurocidin has been recognized as a player in the activation and modulation of the immune response and may act to alarm the immune system. The cationic domain at one side of the protein is essential for its antimicrobial activity. It is stored in azurophil granules as well as secretory granules and as a result partly released at early stage of extravasation. Azurocidin is involved in chemotaxis and activation of monocytes, cytokine release and phagocytosis leading to more efficient bacterial clearance. The primary targeted environment of azurocidin are cells in the bloodstream, that is the endothelial lining, and the extravascular surroundings. The interaction of azurocidin with leucocytes is mediated via beta2-intergrins. High plasma levels of azurocidin might help with the identification of patients which are at risk in developing sepsis.

Long Name

Azurocidin/Cationic Antimicrobial Protein-37/Heparin Binding Protein

Alternate Names

AZAMP, AZU1, CAP37, HBP

Gene Symbol

AZU1

Additional Azurocidin/CAP37/HBP Products

Product Documents for Azurocidin/CAP37/HBP Antibody (z6718)

Certificate of Analysis

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Product Specific Notices for Azurocidin/CAP37/HBP Antibody (z6718)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

Serine Proteases and Regulators

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Protocols

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