BACE-2 Antibody - BSA Free

Novus Biologicals | Catalog # NBP1-77308

Novus Biologicals
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot, ELISA

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free
View all BACE-2 Primary Antibodies »

Product Specifications

Immunogen

Antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human BACE2. The immunogen is located within the last 50 amino acids of BACE2. Amino Acid Squence: CQRRPRDPEVVNDESS

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

57 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for BACE-2 Antibody - BSA Free

Western Blot: BACE-2 AntibodyBSA Free [NBP1-77308]

Western Blot: BACE-2 AntibodyBSA Free [NBP1-77308]

Western Blot: BACE-2 Antibody [NBP1-77308] - Analysis of BACE2 in human heart tissue lysate in the absence (A) or presence (B) of blocking peptide with BACE2 antibody at 1 ug/mL.
BACE-2 Antibody - BSA Free

Immunohistochemistry: BACE-2 Antibody - BSA Free [NBP1-77308] -

Immunohistochemistry: BACE-2 Antibody - BSA Free [NBP1-77308] - Immunohistochemistry of BACE-2 in rat heart tissue with BACE-2 antibody at 2 ug/mL.

Applications for BACE-2 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunohistochemistry

2 ug/ml

Immunohistochemistry-Paraffin

2 ug/ml

Western Blot

1 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: BACE-2

Accumulation of the amyloid-beta (Abeta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. Abeta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by proteases. The long-sought beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2). BACE/Asp2 is a novel transmembrane aspartic protease and co-localizes with APP. A BACE homolog was recently cloned and designated BACE2, Asp1, DRAP (for Down region aspartic protease), and memapsin 1. BACE2 also cleaves APP at b-site and at a different site within Abeta. BACE2 locates on chromosome 21q22.3, the so-called 'Down critical region', suggesting that BACE2 and Abeta may also contribute to the pathogenesis of Down syndrome.

Long Name

beta-site Ayloid Precursor Protein Cleaving Enzyme 2

Alternate Names

BACE2

Gene Symbol

BACE2

UniProt

AAF17078 (Human)

Additional BACE-2 Products

Product Documents for BACE-2 Antibody - BSA Free

Certificate of Analysis

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Product Specific Notices for BACE-2 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

Aspartic Proteases and Regulators

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Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

FAQs for BACE-2 Antibody - BSA Free

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  • Q: Has this antibody been tested in tissue culture cells like HeLa or hek293 for Westerns?

    A: We have not verified western blot in anything other than human heart lysate, which is shown in the image on our website. I checked on the Human Protein Atlas, and it looks like BACE2 should be present in most cell lines. Please see the following link for more information ENSG00000182240.

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