Bcl rambo Antibody - BSA Free

Novus Biologicals | Catalog # NBP3-47871

Novus Biologicals
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Immunohistochemistry, Western Blot, ELISA, Immunocytochemistry/ Immunofluorescence, Immunoprecipitation

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free
View all Bcl rambo Primary Antibodies »

Product Specifications

Immunogen

BCL2-like 13(apoptosis facilitator). (Uniprot# Q9BXK5)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

85 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Bcl rambo Antibody - BSA Free

Bcl rambo Antibody - BSA Free

Immunoprecipitation: Bcl rambo Antibody - BSA Free [NBP3-47871] -

Immunoprecipitation: Bcl rambo Antibody - BSA Free [NBP3-47871] - IP Result of anti-Bcl rambo (IP:, 3ug; Detection: 1:100) with mouse heart tissue lysate 8000ug.
Bcl rambo Antibody - BSA Free

Western Blot: Bcl rambo Antibody - BSA Free [NBP3-47871] -

Western Blot: Bcl rambo Antibody - BSA Free [NBP3-47871] - Jurkat cells were subjected to SDS PAGE followed by western blot with (Bcl rambo antibody) at dilution of 1:500
Bcl rambo Antibody - BSA Free

Immunohistochemistry: Bcl rambo Antibody - BSA Free [NBP3-47871] -

Immunohistochemistry: Bcl rambo Antibody - BSA Free [NBP3-47871] - Immunohistochemistry of paraffin-embedded human pancreas using (Bcl rambo antibody) at dilution of 1:100

Applications for Bcl rambo Antibody - BSA Free

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:50-1:500

Immunohistochemistry

1:50-1:500

Immunoprecipitation

1:500-1:3000

Western Blot

1:1000-1:6000

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS, 50% Glycerol, pH (7.3)

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Bcl rambo

Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Members of the Bcl-2 family are known to be critical regulators of this process. These proteins are characterized by the presence of several conserved motifs termed Bcl-2 homology (BH) domains. A novel, widely expressed member termed Bcl-rambo was recently identified. This protein is localized to mitochondria in mammalian cells and its overexpression induces apoptosis which could be blocked by co-expression of inhibitor of apoptosis proteins (IAPs) such as XIAP, cIAP1, and cIAP2. Bcl-rambo shows overall homology to the anti-apoptotic members containing BH motifs, but unlike Bcl-2, the C-terminal membrane anchor of Bcl-rambo is preceded by a unique 250 amino acid insertion. This region by itself can induce apoptosis more efficiently than the Bcl-2 homology regions, suggesting that Bcl-rambo may be important other pro-apoptotic pathways.

Alternate Names

Bcl2-L-13, BCL2-like 13 (apoptosis facilitator), bcl-2-like protein 13, Bcl-rambo, MIL1BCL-RAMBO, Protein Mil1

Gene Symbol

BCL2L13

Additional Bcl rambo Products

Product Documents for Bcl rambo Antibody - BSA Free

Certificate of Analysis

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Product Specific Notices for Bcl rambo Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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