Catalog Number: 5420
Chemical Name: (3,5-Dibromo-4-hydroxyphenyl)(2-ethyl-3-benzofuranyl)methanone
Biological Activity
TMEM16A/B calcium-activated chloride channel (CaCC) blocker. Inhibits ATP-induced mucin secretion and metacholine-induced airway smooth muscle contraction in vitro.
Technical Data
  • M.Wt:
    424.08
  • Formula:
    C17H12Br2O3
  • Solubility:
    Soluble to 100 mM in DMSO and to 20 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    3562-84-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Functional expression of the TMEM16 family of calcium-activated chloride channels in airway smooth muscle.
    Gallos et al.
    Am.J.Physiol.Lung Cell Mol.Physiol., 2013;305:625
  2. Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction.
    Huang et al.
    Proc.Natl.Acad.Sci.U.S.A., 2012;109:16354

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