Biological ActivityNon-specific endogenous agonist at the inhibitory glycine receptor. More selective than taurine (Cat. No. 0209). Also distinguishes between GABA transporters (IC50 values are 19, 58, 110, 1320 and 5690 μM for rGAT-2, hGAT-3, rGAT-3, hBGT-3 and hGAT-1 respectively). Also MRGPRD agonist.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Tiagabine, SK&F 89976-A, CI 966, and NNC-711 are selective for the cloned GABA transporter GAT-1.
Borden et al.
Pharmacology of the inhibitory glycine receptor: agonist and antagonist actions of amino acids and piperidine carboxylic acid compounds.
Schieden and Betz
A novel antagonist, phenylbenzene ω-phosphono-α-amino acid, for strychnine-sensitive glycine receptors in the rat spinal cord.
Saitoh et al.
Pharmacology and signaling of MAS-related G protein-coupled receptors.
Solinski et al.
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