β-GalNAc-PEG4-Azide

Tocris Bioscience | Catalog # 7780

Asialoglycoprotein receptor ligand with PEG4 linker and azide group for onward chemistry
Tocris Bioscience

Key Product Details

Description

Asialoglycoprotein receptor ligand with PEG4 linker and azide group for onward chemistry
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Product Description

β-GalNAc-PEG4-Azide is a functionalized asialoglycoprotein receptor (ASGPR) ligand for lysosomal targeting chimera (LYTAC) research and development; incorporates a single ASGPR ligand with a PEG4 linker and azide group reactive handle ready for conjugation. It can be used as a building block for multivalent compounds to enhance ASGPR binding. Upon binding to ASGPR, β-GalNAc conjugates are efficiently internalized via ASGPR-mediated endocytosis. β-GalNAc conjugation can be employed as a strategy to effectively deliver cargo such as RNA or Cas9 complexes in a cell-specific manner to hepatocytes. Can be used to generate LYTACs, or labeled with dye for tissue imaging.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Product Specifications for β-GalNAc-PEG4-Azide

Molecular Weight

422.44

Formula

C16H30N4O9

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethyl 2-(acetylamino)-2-deoxy-β-D-galactopyranoside

CAS Number

879004-92-9

PubChem ID

129115265

InChI Key

DWQAFMMYPUXSPI-IBEHDNSVSA-N

SMILES

[N-]=[N+]=NCCOCCOCCOCCO[C@H]1[C@@H]([C@H]([C@H]([C@H](O1)CO)O)O)NC(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

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Background References

References are publications that support the biological activity of the product.

Product Documents for β-GalNAc-PEG4-Azide

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for β-GalNAc-PEG4-Azide

For research use only

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