(-)-Bicuculline methobromide

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0109/10
0109/50
(-)-Bicuculline methobromide | CAS No. 66016-70-4 | GABA-A Receptor Antagonists
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Description: GABAA antagonist; more water soluble version of (+)-bicuculline (Cat. No. 0130)

Chemical Name: [R-(R*,S*)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium bromide

Purity: ≥98%

Product Details
Citations (15)
Supplemental Products
Reviews (1)

Biological Activity

Methobromide salt of (+)-bicuculline. Water soluble and more stable than bicuculline. Non-GABA receptor-mediated actions reported.

Methoiodide Salt and Methochloride Salt also available.

Technical Data

M.Wt:
462.3
Formula:
C21H20BrNO6
Solubility:
Soluble to 50 mM in water
Purity:
≥98%
Storage:
Store at RT
CAS No:
66016-70-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for (-)-Bicuculline methobromide

The citations listed below are publications that use Tocris products. Selected citations for (-)-Bicuculline methobromide include:

15 Citations: Showing 1 - 10

  1. Social modulation during songbird courtship potentiates midbrain DArgic neurons.
    Authors: Huang and Hessler
    PLoS One  ;3:e3281
  2. Pharmacological Dissection of Intrinsic Optical Signal Reveals a Functional Coupling between Synaptic Activity and Astrocytic Volume Transient.
    Authors: Woo Et al.
    Exp Neurobiol  2019;28:30
  3. Activation of Astrocytic μ-Opioid Receptor Causes Conditioned Place Preference.
    Authors: Nam Et al.
    Cell Rep  2019;28:1154
  4. Distinct Inhibitory Circuits Orchestrate Cortical beta and gamma Band Oscillations.
    Authors: Chen Et al.
    Neuron  2017;96:1403
  5. Presynaptic Spike Timing-Dependent Long-Term Depression in the Mouse Hippocampus.
    Authors: Andrade-Talavera Et al.
    Cereb Cortex  2016;26:3637
  6. Synapse-specific compartmentalization of signaling cascades for LTP induction in CA3 interneurons.
    Authors: Galván Et al.
    Neuroscience  2015;290:332
  7. Following the ontogeny of retinal waves: pan-retinal recordings of population dynamics in the neonatal mouse.
    Authors: Maccione Et al.
    J Physiol  2014;592:1545
  8. Extrasynaptic glycine receptors of rodent dorsal raphe serotonergic neurons: a sensitive target for ethanol.
    Authors: Maguire Et al.
    Neuropsychopharmacology  2014;39:1232
  9. Activation of group II metabotropic glutamate receptors induces long-term depression of excitatory synaptic transmission in the substantia nigra pars reticulata.
    Authors: Johnson Et al.
    Neurosci Lett  2011;504:102
  10. Critical involvement of postsynaptic protein kinase activation in long-term potentiation at hippocampal mossy fiber synapses on CA3 interneurons.
    Authors: Galván Et al.
    J Neurosci  2010;30:2844

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Bicuculline as an antagonist of alpha2 glycine receptor
By Anonymous on 05/20/2019
Species: Human

Apart of classical action at GABA-A receptors, bicuculline methobromide (BIC) can be used as a tool to reveal presence of alpha2 glycine receptor (GlyR) subunit.In our work we transfected HEK cells with alpha2 and beta GlyR subunits to obtain heteromeric GlyRs. Application of glycine triggered a clear receptors response, but subsequent addition of BIC decreased response amplitude by >95% (see image). This confirmed expression of alpha2 subunits and their incorporation into active GlyRs.

PMID: 30875431

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