(-)-Bicuculline methobromide

  ( 10 citations )    
Product Datasheet
Catalog Number:0109
Chemical Name:[R-(R*,S*)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium bromide
Product Details
Citations (10)
Supplemental Products
Reviews
Biological Activity
Methobromide salt of (+)-bicuculline. Water soluble and more stable than bicuculline. Non-GABA receptor-mediated actions reported.

Methoiodide Salt and Methochloride Salt also available.

Technical Data
  • M.Wt:
    462.3
  • Formula:
    C21H20BrNO6
  • Solubility:
    Soluble to 50 mM in water
  • Purity:
    >98
  • Storage:
    Store at RT
  • CAS No:
    73604-30-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for (-)-Bicuculline methobromide include:

10 Citations: Showing 1 - 10
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  1. Social modulation during songbird courtship potentiates midbrain dopaminergic neurons.
    Authors: Huang and Hessler
    PLoS One  ;3:e3281
  2. Synapse-specific compartmentalization of signaling cascades for LTP induction in CA3 interneurons.
    Authors: Galván Et al.
    Neuroscience  2015;290:332
  3. Following the ontogeny of retinal waves: pan-retinal recordings of population dynamics in the neonatal mouse.
    Authors: Maccione Et al.
    J Physiol  2014;592:1545
  4. Extrasynaptic glycine receptors of rodent dorsal raphe serotonergic neurons: a sensitive target for ethanol.
    Authors: Maguire Et al.
    Neuropsychopharmacology  2014;39:1232
  5. Activation of group II metabotropic glutamate receptors induces long-term depression of excitatory synaptic transmission in the substantia nigra pars reticulata.
    Authors: Johnson Et al.
    Neurosci Lett  2011;504:102
  6. Critical involvement of postsynaptic protein kinase activation in long-term potentiation at hippocampal mossy fiber synapses on CA3 interneurons.
    Authors: Galván Et al.
    J Neurosci  2010;30:2844
  7. Postsynaptic spiking homeostatically induces cell-autonomous regulation of inhibitory inputs via retrograde signaling.
    Authors: Peng Et al.
    J Neurosci  2010;30:16220
  8. Compensatory enhancement of intrinsic spiking upon NKCC1 disruption in neonatal hippocampus.
    Authors: Sipilä Et al.
    J Neurosci  2009;29:6982
  9. GABA receptor activation in the lumbosacral spinal cord decreases detrusor overactivity in spinal cord injured rats.
    Authors: Miyazato Et al.
    J Urol  2008;179:1178
  10. Tonically active inhibition selectively controls feedforward circuits in mouse barrel cortex.
    Authors: Krook-Magnuson Et al.
    J Neurophysiol  2008;100:932

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