Chemical Name: [R-(R*,S*)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium bromide
Biological ActivityMethobromide salt of (+)-bicuculline. Water soluble and more stable than bicuculline. Non-GABA receptor-mediated actions reported.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Recent advances in the pharmacology of quaternary salts of bicuculline.
Seutin and Johnson
Characteristics of GABAB receptor binding sites on rat whole brain synaptic membranes.
Bowery et al.
Nigral infusions of muscimol or bicuculline facilitate seizures in developing rats.
Sperber et al.
Brain Res., 1987;465:243
Citations for (-)-Bicuculline methobromide
The citations listed below are publications that use Tocris products. Selected citations for (-)-Bicuculline methobromide include:
15 Citations: Showing 1 - 10
Social modulation during songbird courtship potentiates midbrain DArgic neurons.
Authors: Huang and Hessler
PLoS One ;3:e3281
Pharmacological Dissection of Intrinsic Optical Signal Reveals a Functional Coupling between Synaptic Activity and Astrocytic Volume Transient.
Authors: Woo Et al.
Exp Neurobiol 2019;28:30
Activation of Astrocytic μ-Opioid Receptor Causes Conditioned Place Preference.
Authors: Nam Et al.
Cell Rep 2019;28:1154
Distinct Inhibitory Circuits Orchestrate Cortical beta and gamma Band Oscillations.
Authors: Chen Et al.
Presynaptic Spike Timing-Dependent Long-Term Depression in the Mouse Hippocampus.
Authors: Andrade-Talavera Et al.
Cereb Cortex 2016;26:3637
Synapse-specific compartmentalization of signaling cascades for LTP induction in CA3 interneurons.
Authors: Galván Et al.
Following the ontogeny of retinal waves: pan-retinal recordings of population dynamics in the neonatal mouse.
Authors: Maccione Et al.
J Physiol 2014;592:1545
Extrasynaptic glycine receptors of rodent dorsal raphe serotonergic neurons: a sensitive target for ethanol.
Authors: Maguire Et al.
Activation of group II metabotropic glutamate receptors induces long-term depression of excitatory synaptic transmission in the substantia nigra pars reticulata.
Authors: Johnson Et al.
Neurosci Lett 2011;504:102
Critical involvement of postsynaptic protein kinase activation in long-term potentiation at hippocampal mossy fiber synapses on CA3 interneurons.
Authors: Galván Et al.
J Neurosci 2010;30:2844
Postsynaptic spiking homeostatically induces cell-autonomous regulation of inhibitory inputs via retrograde signaling.
Authors: Peng Et al.
J Neurosci 2010;30:16220
Compensatory enhancement of intrinsic spiking upon NKCC1 disruption in neonatal hippocampus.
Authors: Sipilä Et al.
J Neurosci 2009;29:6982
GABA receptor activation in the lumbosacral spinal cord decreases detrusor overactivity in spinal cord injured rats.
Authors: Miyazato Et al.
J Urol 2008;179:1178
Tonically active inhibition selectively controls feedforward circuits in mouse barrel cortex.
Authors: Krook-Magnuson Et al.
J Neurophysiol 2008;100:932
GABA regulates dendritic growth by stabilizing lamellipodia in newly generated interneurons of the olfactory bulb.
Authors: Gascon Et al.
J Neurosci 2006;26:12956
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Apart of classical action at GABA-A receptors, bicuculline methobromide (BIC) can be used as a tool to reveal presence of alpha2 glycine receptor (GlyR) subunit.In our work we transfected HEK cells with alpha2 and beta GlyR subunits to obtain heteromeric GlyRs. Application of glycine triggered a clear receptors response, but subsequent addition of BIC decreased response amplitude by >95% (see image). This confirmed expression of alpha2 subunits and their incorporation into active GlyRs.