Catalog Number: 0131
Chemical Name: [R-(R*,S*)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium chloride
Biological Activity
Methochloride salt of (+)-bicuculline (Cat. No. 0130). Water soluble and more stable than bicuculline. Non-GABA receptor-mediated actions reported.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Recent advances in the pharmacology of quaternary salts of bicuculline.
    Seutin and Johnson
    TiPS, 1999;20:268
  2. Quantitative evaluation of the potencies of GABA-receptor agonists and antagonists using the rat hippocampal slice preparation.
    Kemp et al.
    Br.J.Pharmacol., 1986;87:677
  3. Evidence for a non-GABAergic action of quaternary salts of bicuculline on dopaminergic neurones.
    Seutin et al.
    Neuropharmacology, 1997;36:1653

The citations listed below are publications that use Tocris products. Selected citations for (-)-Bicuculline methochloride include:

Showing Results 1 - 10 of 13

  1. Basal adenosine modulates the functional properties of AMPA receptors in mouse hippocampal neurons through the activation of A1R A2AR and A3R.
    Authors: Angelantonio Et al.
    Front Cell Neurosci
  2. Reduction in focal ictal activity following transplantation of MGE interneurons requires expression of the GABAA receptor α4 subunit.
    Authors: Jaiswal Et al.
    Front Cell Neurosci
  3. Protein tyrosine phosphatase receptor type R is required for Purkinje cell responsiveness in cerebellar long-term depression.
    Authors: Erkens Et al.
    Mol Brain
  4. High salt intake increases blood pressure via BDNF-mediated downregulation of KCC2 and impaired baroreflex inhibition of vasopressin neurons.
    Authors: Choe Et al.
  5. Absence of plateau potentials in dLGN cells leads to a breakdown in retinogeniculate refinement.
    Authors: Dilger Et al.
    J Neurosci
  6. Lack of kinase regulation of canonical transient receptor potential 3 (TRPC3) channel-dependent currents in cerebellar Purkinje cells.
    Authors: Nelson and Glitsch
    J Biol Chem
  7. Requirements for synaptically evoked plateau potentials in relay cells of the dorsal lateral geniculate nucleus of the mouse.
    Authors: Dilger Et al.
    J Physiol
  8. Lateral superior olive function in congenital deafness.
    Authors: Couchman Et al.
    Hear Res
  9. Metaplasticity of amygdalar responses to the stress hormone corticosterone.
    Authors: Karst Et al.
    Proc Natl Acad Sci U S A
  10. Neuregulin-1 enhances depolarization-induced GABA release.
    Authors: Woo Et al.
  11. Calcium release from presynaptic internal stores is required for ethanol to increase spontaneous γ-aminobutyric acid release onto cerebellum Purkinje neurons.
    Authors: Kelm Et al.
    J Pharmacol Exp Ther
  12. ERK activation causes epilepsy by stimulating NMDA receptor activity.
    Authors: Nateri Et al.
    EMBO J
  13. A hippocampal interneuron associated with the mossy fiber system.
    Authors: Vida and Frotscher
    Proc Natl Acad Sci U S A
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