Catalog Number: 0131
Chemical Name: [R-(R*,S*)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium chloride
Biological Activity
Methochloride salt of (+)-bicuculline. Water soluble and more stable than bicuculline. Non-GABA receptor-mediated actions reported.

Methoiodide Salt and Methobromide Salt also available.

Technical Data
  • M.Wt:
    417.85
  • Formula:
    C21H20ClNO6
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    53552-05-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Recent advances in the pharmacology of quaternary salts of bicuculline.
    Seutin and Johnson
    TiPS, 1999;20:268
  2. Quantitative evaluation of the potencies of GABA-receptor agonists and antagonists using the rat hippocampal slice preparation.
    Kemp et al.
    Br.J.Pharmacol., 1986;87:677
  3. Evidence for a non-GABAergic action of quaternary salts of bicuculline on dopaminergic neurones.
    Seutin et al.
    Neuropharmacology, 1997;36:1653
Citations:

The citations listed below are publications that use Tocris products. Selected citations for (-)-Bicuculline methochloride include:

13 Citations: Showing 1 - 10
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  1. Basal adenosine modulates the functional properties of AMPA receptors in mouse hippocampal neurons through the activation of A1R A2AR and A3R.
    Authors: Angelantonio Et al.
    Front Cell Neurosci 2015;9:409
  2. Reduction in focal ictal activity following transplantation of MGE interneurons requires expression of the GABAA receptor α4 subunit.
    Authors: Jaiswal Et al.
    Front Cell Neurosci 2015;9:127
  3. Protein tyrosine phosphatase receptor type R is required for Purkinje cell responsiveness in cerebellar long-term depression.
    Authors: Erkens Et al.
    Mol Brain 2015;8:1
  4. High salt intake increases blood pressure via BDNF-mediated downregulation of KCC2 and impaired baroreflex inhibition of vasopressin neurons.
    Authors: Choe Et al.
    Neuron 2015;85:549
  5. Absence of plateau potentials in dLGN cells leads to a breakdown in retinogeniculate refinement.
    Authors: Dilger Et al.
    J Neurosci 2015;35:3652
  6. Lack of kinase regulation of canonical transient receptor potential 3 (TRPC3) channel-dependent currents in cerebellar Purkinje cells.
    Authors: Nelson and Glitsch
    J Biol Chem 2012;287:6326
  7. Requirements for synaptically evoked plateau potentials in relay cells of the dorsal lateral geniculate nucleus of the mouse.
    Authors: Dilger Et al.
    J Physiol 2011;589:919
  8. Lateral superior olive function in congenital deafness.
    Authors: Couchman Et al.
    Hear Res 2011;277:163
  9. Metaplasticity of amygdalar responses to the stress hormone corticosterone.
    Authors: Karst Et al.
    Proc Natl Acad Sci U S A 2010;107:14449
  10. Neuregulin-1 enhances depolarization-induced GABA release.
    Authors: Woo Et al.
    Neuron 2007;54:599
  11. Calcium release from presynaptic internal stores is required for ethanol to increase spontaneous γ-aminobutyric acid release onto cerebellum Purkinje neurons.
    Authors: Kelm Et al.
    J Pharmacol Exp Ther 2007;323:356
  12. ERK activation causes epilepsy by stimulating NMDA receptor activity.
    Authors: Nateri Et al.
    EMBO J 2007;26:4891
  13. A hippocampal interneuron associated with the mossy fiber system.
    Authors: Vida and Frotscher
    Proc Natl Acad Sci U S A 2000;97:1275
Expand to show all 13 Citations
Average Rating: 5 (Based on 1 review)

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