(-)-Bicuculline methochloride

Catalog # Availability Size / Price Qty
(-)-Bicuculline methochloride | CAS No. 38641-83-7 | GABA-A Receptor Antagonists
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Description: GABAA antagonist; more water soluble version of (+)-bicuculline (Cat. No. 0130)

Chemical Name: [R-(R*,S*)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium chloride

Purity: ≥99%

Product Details
Citations (23)
Supplemental Products
Reviews (1)

Biological Activity

(-)-Bicuculline methochloride is a methochloride salt of (+)-bicuculline. Water soluble and more stable than bicuculline. Non-GABA receptor-mediated actions reported.

Methoiodide Salt and Methobromide Salt also available.

Technical Data

Soluble to 100 mM in water
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

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Citations for (-)-Bicuculline methochloride

The citations listed below are publications that use Tocris products. Selected citations for (-)-Bicuculline methochloride include:

23 Citations: Showing 1 - 10

  1. Chronic postnatal chemogenetic activation of forebrain excitatory neurons evokes persistent changes in mood behavior
    Authors: Pati Et al.
    ELife  2020;9
  2. Myosin VI Drives Clathrin-Mediated AMPA Receptor Endocytosis to Facilitate Cerebellar Long-Term Depression.
    Authors: Wagner Et al.
    Cell Rep  2019;28:11
  3. Alternative 3' UTRs Modify the Localization, Regulatory Potential, Stability, and Plasticity of mRNAs in Neuronal Compartments.
    Authors: Tushev Et al.
    Neuron  2018;98:495
  4. CAST/ELKS Proteins Control Voltage-Gated Ca2+ Channel Density and Synaptic Release Probability at a Mammalian Central Synapse.
    Authors: Dong Et al.
    Cell Rep  2018;24:284
  5. Molecular Mechanisms of Synaptic Vesicle Priming by Munc13 and Munc18.
    Authors: Lai Et al.
    Neuron  2017;95:591
  6. Formation and Maintenance of Functional Spines in the Absence of Presynaptic Glutamate Release.
    Authors: Sigler Et al.
    Neuron  2017;94:304
  7. Basal adenosine modulates the functional properties of AMPA receptors in mouse hippocampal neurons through the activation of A1R A2AR and A3R.
    Authors: Angelantonio Et al.
    Front Cell Neurosci  2015;9:409
  8. Reduction in focal ictal activity following transplantation of MGE interneurons requires expression of the GABAA receptor α4 subunit.
    Authors: Jaiswal Et al.
    Front Cell Neurosci  2015;9:127
  9. Protein tyrosine phosphatase receptor type R is required for Purkinje cell responsiveness in cerebellar long-term depression.
    Authors: Erkens Et al.
    Mol Brain  2015;8:1
  10. High salt intake increases blood pressure via BDNF-mediated downregulation of KCC2 and impaired baroreflex inhibition of vasopressin neurons.
    Authors: Choe Et al.
    Neuron  2015;85:549
  11. Absence of plateau potentials in dLGN cells leads to a breakdown in retinogeniculate refinement.
    Authors: Dilger Et al.
    J Neurosci  2015;35:3652
  12. Activation of group I metabotropic glutamate receptors potentiates heteromeric kainate receptors.
    Authors: Rojas Et al.
    Mol Pharmacol  2013;83:106
  13. T-type channel blockade impairs long-term potentiation at the parallel fiber-Purkinje cell synapse and cerebellar learning.
    Authors: Ly Et al.
    Proc Natl Acad Sci U S A  2013;110:20302
  14. Lack of kinase regulation of canonical transient receptor potential 3 (TRPC3) channel-dependent currents in cerebellar Purkinje cells.
    Authors: Nelson and Glitsch
    J Biol Chem  2012;287:6326
  15. Requirements for synaptically evoked plateau potentials in relay cells of the dorsal lateral geniculate nucleus of the mouse.
    Authors: Dilger Et al.
    J Physiol  2011;589:919
  16. Lateral superior olive function in congenital deafness.
    Authors: Couchman Et al.
    Hear Res  2011;277:163
  17. Activation of native TRPC3 cation channels by phospholipase D.
    Authors: Glitsch
    FASEB J  2010;24:318
  18. Metaplasticity of amygdalar responses to the stress hormone corticosterone.
    Authors: Karst Et al.
    Proc Natl Acad Sci U S A  2010;107:14449
  19. Neuregulin-1 enhances depolarization-induced GABA release.
    Authors: Woo Et al.
    Neuron  2007;54:599
  20. Calcium release from presynaptic internal stores is required for ethanol to increase spontaneous γ-aminobutyric acid release onto cerebellum Purkinje neurons.
    Authors: Kelm Et al.
    J Pharmacol Exp Ther  2007;323:356
  21. ERK activation causes epilepsy by stimulating NMDA receptor activity.
    Authors: Nateri Et al.
    EMBO J  2007;26:4891
  22. Spontaneous synaptic activity is primarily GABAergic in vestibular nucleus neurons of the chick embryo.
    Authors: Shao Et al.
    J Neurophysiol  2003;90:1182
  23. A hippocampal interneuron associated with the mossy fiber system.
    Authors: Vida and Frotscher
    Proc Natl Acad Sci U S A  2000;97:1275


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Increased excitability with GABAA antagonism
By Anonymous on 10/20/2017

Bath application of Bicuculline methochloride increased overall excitation of neurons in slice.

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