Chemical Name: [R-(R*,S*)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium chloride
Biological Activity(-)-Bicuculline methochloride is a methochloride salt of (+)-bicuculline. Water soluble and more stable than bicuculline. Non-GABA receptor-mediated actions reported.
Methoiodide Salt and Methobromide Salt also available.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Recent advances in the pharmacology of quaternary salts of bicuculline.
Seutin and Johnson
Quantitative evaluation of the potencies of GABA-receptor agonists and antagonists using the rat hippocampal slice preparation.
Kemp et al.
Evidence for a non-GABAergic action of quaternary salts of bicuculline on DArgic neurones.
Seutin et al.
Citations for (-)-Bicuculline methochloride
The citations listed below are publications that use Tocris products. Selected citations for (-)-Bicuculline methochloride include:
23 Citations: Showing 1 - 10
Chronic postnatal chemogenetic activation of forebrain excitatory neurons evokes persistent changes in mood behavior
Authors: Pati Et al.
Myosin VI Drives Clathrin-Mediated AMPA Receptor Endocytosis to Facilitate Cerebellar Long-Term Depression.
Authors: Wagner Et al.
Cell Rep 2019;28:11
Alternative 3' UTRs Modify the Localization, Regulatory Potential, Stability, and Plasticity of mRNAs in Neuronal Compartments.
Authors: Tushev Et al.
CAST/ELKS Proteins Control Voltage-Gated Ca2+ Channel Density and Synaptic Release Probability at a Mammalian Central Synapse.
Authors: Dong Et al.
Cell Rep 2018;24:284
Molecular Mechanisms of Synaptic Vesicle Priming by Munc13 and Munc18.
Authors: Lai Et al.
Formation and Maintenance of Functional Spines in the Absence of Presynaptic Glutamate Release.
Authors: Sigler Et al.
Basal adenosine modulates the functional properties of AMPA receptors in mouse hippocampal neurons through the activation of A1R A2AR and A3R.
Authors: Angelantonio Et al.
Front Cell Neurosci 2015;9:409
Reduction in focal ictal activity following transplantation of MGE interneurons requires expression of the GABAA receptor α4 subunit.
Authors: Jaiswal Et al.
Front Cell Neurosci 2015;9:127
Protein tyrosine phosphatase receptor type R is required for Purkinje cell responsiveness in cerebellar long-term depression.
Authors: Erkens Et al.
Mol Brain 2015;8:1
High salt intake increases blood pressure via BDNF-mediated downregulation of KCC2 and impaired baroreflex inhibition of vasopressin neurons.
Authors: Choe Et al.
Absence of plateau potentials in dLGN cells leads to a breakdown in retinogeniculate refinement.
Authors: Dilger Et al.
J Neurosci 2015;35:3652
Activation of group I metabotropic glutamate receptors potentiates heteromeric kainate receptors.
Authors: Rojas Et al.
Mol Pharmacol 2013;83:106
T-type channel blockade impairs long-term potentiation at the parallel fiber-Purkinje cell synapse and cerebellar learning.
Authors: Ly Et al.
Proc Natl Acad Sci U S A 2013;110:20302
Lack of kinase regulation of canonical transient receptor potential 3 (TRPC3) channel-dependent currents in cerebellar Purkinje cells.
Authors: Nelson and Glitsch
J Biol Chem 2012;287:6326
Requirements for synaptically evoked plateau potentials in relay cells of the dorsal lateral geniculate nucleus of the mouse.
Authors: Dilger Et al.
J Physiol 2011;589:919
Lateral superior olive function in congenital deafness.
Authors: Couchman Et al.
Hear Res 2011;277:163
Activation of native TRPC3 cation channels by phospholipase D.
FASEB J 2010;24:318
Metaplasticity of amygdalar responses to the stress hormone corticosterone.
Authors: Karst Et al.
Proc Natl Acad Sci U S A 2010;107:14449
Neuregulin-1 enhances depolarization-induced GABA release.
Authors: Woo Et al.
Calcium release from presynaptic internal stores is required for ethanol to increase spontaneous γ-aminobutyric acid release onto cerebellum Purkinje neurons.
Authors: Kelm Et al.
J Pharmacol Exp Ther 2007;323:356
ERK activation causes epilepsy by stimulating NMDA receptor activity.
Authors: Nateri Et al.
EMBO J 2007;26:4891
Spontaneous synaptic activity is primarily GABAergic in vestibular nucleus neurons of the chick embryo.
Authors: Shao Et al.
J Neurophysiol 2003;90:1182
A hippocampal interneuron associated with the mossy fiber system.
Authors: Vida and Frotscher
Proc Natl Acad Sci U S A 2000;97:1275
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Bath application of Bicuculline methochloride increased overall excitation of neurons in slice.