(-)-Bicuculline methochloride

  ( 14 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:0131
Chemical Name:[R-(R*,S*)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium chloride
Product Details
Citations (14)
Supplemental Products
Reviews
Biological Activity
Methochloride salt of (+)-bicuculline. Water soluble and more stable than bicuculline. Non-GABA receptor-mediated actions reported.

Methoiodide Salt and Methobromide Salt also available.

Technical Data
  • M.Wt:
    417.85
  • Formula:
    C21H20ClNO6
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    53552-05-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for (-)-Bicuculline methochloride include:

14 Citations: Showing 1 - 10
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  1. Basal adenosine modulates the functional properties of AMPA receptors in mouse hippocampal neurons through the activation of A1R A2AR and A3R.
    Authors: Angelantonio Et al.
    Front Cell Neurosci  2015;9:409
  2. Reduction in focal ictal activity following transplantation of MGE interneurons requires expression of the GABAA receptor α4 subunit.
    Authors: Jaiswal Et al.
    Front Cell Neurosci  2015;9:127
  3. Protein tyrosine phosphatase receptor type R is required for Purkinje cell responsiveness in cerebellar long-term depression.
    Authors: Erkens Et al.
    Mol Brain  2015;8:1
  4. High salt intake increases blood pressure via BDNF-mediated downregulation of KCC2 and impaired baroreflex inhibition of vasopressin neurons.
    Authors: Choe Et al.
    Neuron  2015;85:549
  5. Absence of plateau potentials in dLGN cells leads to a breakdown in retinogeniculate refinement.
    Authors: Dilger Et al.
    J Neurosci  2015;35:3652
  6. Lack of kinase regulation of canonical transient receptor potential 3 (TRPC3) channel-dependent currents in cerebellar Purkinje cells.
    Authors: Nelson and Glitsch
    J Biol Chem  2012;287:6326
  7. Requirements for synaptically evoked plateau potentials in relay cells of the dorsal lateral geniculate nucleus of the mouse.
    Authors: Dilger Et al.
    J Physiol  2011;589:919
  8. Lateral superior olive function in congenital deafness.
    Authors: Couchman Et al.
    Hear Res  2011;277:163
  9. Metaplasticity of amygdalar responses to the stress hormone corticosterone.
    Authors: Karst Et al.
    Proc Natl Acad Sci U S A  2010;107:14449
  10. Neuregulin-1 enhances depolarization-induced GABA release.
    Authors: Woo Et al.
    Neuron  2007;54:599
  11. Calcium release from presynaptic internal stores is required for ethanol to increase spontaneous γ-aminobutyric acid release onto cerebellum Purkinje neurons.
    Authors: Kelm Et al.
    J Pharmacol Exp Ther  2007;323:356
  12. ERK activation causes epilepsy by stimulating NMDA receptor activity.
    Authors: Nateri Et al.
    EMBO J  2007;26:4891
  13. Spontaneous synaptic activity is primarily GABAergic in vestibular nucleus neurons of the chick embryo.
    Authors: Shao Et al.
    J Neurophysiol  2003;90:1182
  14. A hippocampal interneuron associated with the mossy fiber system.
    Authors: Vida and Frotscher
    Proc Natl Acad Sci U S A  2000;97:1275
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Average Rating: 5 (Based on 1 review)

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Pub Med ID 28185854

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