(±)-Blebbistatin

  ( 34 citations )    
Product Datasheet
Catalog Number:1760
Chemical Name:(±)-1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-b]quinolin-4-one
Product Details
Citations (34)
Supplemental Products
Reviews
Biological Activity
Selective inhibitor of myosin II ATPase activity; inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. Rapidly and reversibly blocks cell blebbing, and disrupts directed cell migration and cytokinesis in vertebrate cells.

Active and Inactive Enantiomer also available.

Technical Data
  • M.Wt:
    292.34
  • Formula:
    C18H16N2O2
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at +4°C
  • CAS No:
    674289-55-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for (±)-Blebbistatin include:

34 Citations: Showing 1 - 10
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  1. ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth.
    Authors: Rath Et al.
    EMBO Mol Med  2017;9:198
  2. MYH9 is an Essential Factor for Porcine Reproductive and Respiratory Syndrome Virus Infection.
    Authors: Gao Et al.
    Nat Commun  2016;6:25120
  3. Real-time two- and three-dimensional imaging of monocyte motility and navigation on planar surfaces and in collagen matrices: roles of Rho.
    Authors: Bzymek Et al.
    Sci Rep  2016;6:25016
  4. Myocardial Infarction Causes Transient Cholinergic Transdifferentiation of Cardiac Sympathetic Nerves via gp130.
    Authors: Olivas Et al.
    J Neurosci  2016;36:479
  5. Substrate stress relaxation regulates cell spreading.
    Authors: Chaudhuri Et al.
    Int J Nanomedicine  2015;6:6364
  6. Expression of α-Smooth Muscle Actin Determines the Fate of Mesenchymal Stromal Cells.
    Authors: Talele Et al.
    Stem Cell Reports  2015;4:1016
  7. Mechanical coupling between transsynaptic N-cadherin adhesions and actin flow stabilizes dendritic spines.
    Authors: Chazeau Et al.
    Int J Cancer  2015;26:859
  8. ZO-1 controls endothelial adherens junctions, cell-cell tension, angiogenesis, and barrier formation.
    Authors: Tornavaca Et al.
    Cell  2015;208:821
  9. Cortical contractility triggers a stochastic switch to fast amoeboid cell motility.
    Authors: Ruprecht Et al.
    PLoS One  2015;160:673
  10. SDF-1α stiffens myeloma bone marrow mesenchymal stromal cells through the activation of RhoA-ROCK-Myosin II.
    Authors: Choi Et al.
    J Cell Biol  2015;136:E219
  11. Atherosclerosis exacerbates arrhythmia following myocardial infarction: Role of myocardial inflammation.
    Authors: Jesus Et al.
    Mol Biol Cell  2015;12:169
  12. Role of sarcoplasmic reticulum calcium in development of secondary calcium rise and early afterdepolarizations in long QT syndrome rabbit model.
    Authors: Chang Et al.
    J Cell Sci  2015;10:e0123868
  13. Simvastatin enhances Rho/actin/cell rigidity pathway contributing to mesenchymal stem cells' osteogenic differentiation.
    Authors: Tai Et al.
    Heart Rhythm  2015;10:5881
  14. Live Cell Interferometry Quantifies Dynamics of Biomass Partitioning during Cytokinesis.
    Authors: Zangle Et al.
    PLoS One  2014;9:e115726
  15. Optical mapping of sarcoplasmic reticulum Ca2+ in the intact heart: ryanodine receptor refractoriness during alternans and fibrillation.
    Authors: Wang Et al.
    Circ Res  2014;114:1410
  16. Organ explant culture of neonatal rat ventricles: a new model to study gene and cell therapy.
    Authors: Haan Et al.
    PLoS One  2013;8:e59290
  17. Sinoatrial node reentry in a canine chronic left ventricular infarct model: role of intranodal fibrosis and heterogeneity of refractoriness.
    Authors: Glukhov Et al.
    Circ Arrhythm Electrophysiol  2013;6:984
  18. Functional roles of KATP channel subunits in metabolic inhibition.
    Authors: Glukhov Et al.
    J Mol Cell Cardiol  2013;62:90
  19. Mitochondrial dysfunction causing cardiac sodium channel downregulation in cardiomyopathy.
    Authors: Liu Et al.
    J Mol Cell Cardiol  2013;54:25
  20. Shaping organs by a wingless-int/Notch/nonmuscle myosin module which orients feather bud elongation.
    Authors: Li Et al.
    Proc Natl Acad Sci U S A  2013;110:E1452
  21. LTP induction translocates cortactin at distant synapses in wild-type but not Fmr1 knock-out mice.
    Authors: Seese Et al.
    J Neurosci  2012;32:7403
  22. CD36 protein influences myocardial Ca2+ homeostasis and phospholipid metabolism: conduction anomalies in CD36-deficient mice during fasting.
    Authors: Pietka Et al.
    J Biol Chem  2012;287:38901
  23. A Rho GTPase signal treadmill backs a contractile array.
    Authors: Burkel Et al.
    Dev Cell  2012;23:384
  24. Contractile Activity Regulates Inducible Nitric Oxide Synthase Expression and NO(i) Production in Cardiomyocytes via a FAK-Dependent Signaling Pathway.
    Authors: Chu Et al.
    J Signal Transduct  2012;2012:473410
  25. Effects of KATP channel openers diazoxide and pinacidil in coronary-perfused atria and ventricles from failing and non-failing human hearts.
    Authors: Fedorov Et al.
    J Mol Cell Cardiol  2011;51:215
  26. RhoJ/TCL regulates endothelial motility and tube formation and modulates actomyosin contractility and focal adhesion numbers.
    Authors: Kaur Et al.
    Arterioscler Thromb Vasc Biol  2011;31:657
  27. Role of Pyk2 in cardiac arrhythmogenesis.
    Authors: Lang Et al.
    J Inflamm (Lond)  2011;301:H975
  28. 'White wave' analysis of epithelial scratch wound healing reveals how cells mobilise back from the leading edge in a myosin-II-dependent fashion.
    Authors: Matsubayashi Et al.
    Proc Natl Acad Sci U S A  2011;124:1017
  29. Transmural heterogeneity and remodeling of ventricular excitation-contraction coupling in human heart failure.
    Authors: Lou Et al.
    Circulation  2011;123:1881
  30. Optical mapping of action potentials and calcium transients in the mouse heart.
    Authors: Lang Et al.
    J Vis Exp  2011;
  31. Emergence of patterned stem cell differentiation within multicellular structures.
    Authors: Ruiz and Chen
    Sci Rep  2008;26:2921
  32. Rac1-null mouse embryonic fibroblasts are motile and respond to platelet-derived growth factor.
    Authors: Vidali Et al.
    Mol Biol Cell  2006;17:2377
  33. Reassembly of contractile actin cortex in cell blebs.
    Authors: Charras Et al.
    J Cell Biol  2006;175:477
  34. Emergent patterns of growth controlled by multicellular form and mechanics.
    Authors: Nelson Et al.
    Am J Physiol Heart Circ Physiol  2005;102:11594
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