Catalog Number: 3221
Chemical Name: 1,1'-(1,12-Dodecanediyl)bis[3-methylpyridinium] dibromide
Biological Activity
Orthosteric neuronal nicotinic acetylcholine receptor (nAChR) antagonist (IC50 values are 0.17, 0.25, 0.4, 4.8, 6.5, 8.2, 20 and 34 μM at α3β4, α1β1εδ, α3β4β3, α6β4β3, α7, α4β2, α3β2β3 and α6/3β2β3 receptors respectively). Attenuates nicotine-evoked dopamine release from the ventral tegmental area in vivo (IC50 = 0.2 nM) and reduces nicotine self-administration in rats. Brain penetrant.
Technical Data
  • M.Wt:
    514.38
  • Formula:
    C24H38Br2N2
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Desiccate at RT
  • CAS No:
    525596-66-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. N,N'alkane-diyl-bis-3-picoliniums as nicotinic receptor antagonists: Inhibition of nicotine-evoked dopamine release and hyperactivity.
    Dwoskin et al.
    J.Pharmacol.Exp.Ther., 2008;326:563
  2. Region-specific effects of the N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide on nicotine-induced increase in extracellular dopamine in vivo.
    Rahman et al.
    Br.J.Pharmacol., 2008;153:792
  3. Bis-azaaromatic quaternary ammonium analogues: ligands for α4β2* and β7* subtypes of neuronal nicotinic receptors
    Ayers et al.
    Bioorg.Med.Chem.Letts., 2002;12:3067
Citations:

The citations listed below are publications that use Tocris products. Selected citations for bPiDDB include:

1 Citations: Showing 1 - 1

  1. Pharmacologically distinct nicotinic acetylcholine receptors drive efferent-mediated excitation in calyx-bearing vestibular afferents.
    Authors: Holt Et al.
    J Cell Biol 2015;35:3625

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