bPiDDB

  ( 1 citations )    
Product Datasheet
Catalog Number:3221
Chemical Name:1,1'-(1,12-Dodecanediyl)bis[3-methylpyridinium] dibromide
Product Details
Citations (1)
Reviews
Biological Activity
Orthosteric neuronal nicotinic acetylcholine receptor (nAChR) antagonist (IC50 values are 0.17, 0.25, 0.4, 4.8, 6.5, 8.2, 20 and 34 μM at α3β4, α1β1εδ, α3β4β3, α6β4β3, α7, α4β2, α3β2β3 and α6/3β2β3 receptors respectively). Attenuates nicotine-evoked dopamine release from the ventral tegmental area in vivo (IC50 = 0.2 nM) and reduces nicotine self-administration in rats. Brain penetrant.
Technical Data
  • M.Wt:
    514.38
  • Formula:
    C24H38Br2N2
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Desiccate at RT
  • CAS No:
    525596-66-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for bPiDDB include:

1 Citations: Showing 1 - 1

  1. Pharmacologically distinct nicotinic acetylcholine receptors drive efferent-mediated excitation in calyx-bearing vestibular afferents.
    Authors: Holt Et al.
    J Cell Biol  2015;35:3625

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