bPiDDB

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bPiDDB | CAS No. 525596-66-1 | Additional Nicotinic Receptor Antagonists
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Description: Orthosteric neuronal nAChR antagonist

Chemical Name: 1,1'-(1,12-Dodecanediyl)bis[3-methylpyridinium] dibromide

Purity: ≥98%

Product Details
Citations (1)
Reviews

Biological Activity

Orthosteric neuronal nicotinic acetylcholine receptor (nAChR) antagonist (IC50 values are 0.17, 0.25, 0.4, 4.8, 6.5, 8.2, 20 and 34 μM at α3β4, α1β1εδ, α3β4β3, α6β4β3, α7, α4β2, α3β2β3 and α6/3β2β3 receptors respectively). Attenuates nicotine-evoked dopamine release from the ventral tegmental area in vivo (IC50 = 0.2 nM) and reduces nicotine self-administration in rats. Brain penetrant.

Technical Data

M.Wt:
514.38
Formula:
C24H38Br2N2
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
525596-66-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. N,N'alkane-diyl-bis-3-picoliniums as nicotinic receptor antagonists: Inhibition of nicotine-evoked DA release and hyperactivity.
    Dwoskin et al.
    J.Pharmacol.Exp.Ther., 2008;326:563
  2. Region-specific effects of the N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide on nicotine-induced increase in extracellular DA in vivo.
    Rahman et al.
    Br.J.Pharmacol., 2008;153:792
  3. Bis-azaaromatic quaternary ammonium analogues: ligands for α4β2* and β7* subtypes of neuronal nicotinic receptors
    Ayers et al.
    Bioorg.Med.Chem.Letts., 2002;12:3067

Product Datasheets

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Citation for bPiDDB

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