Chemical Name: 1,1'-(1,12-Dodecanediyl)bis[3-methylpyridinium] dibromide
Biological ActivityOrthosteric neuronal nicotinic acetylcholine receptor (nAChR) antagonist (IC50 values are 0.17, 0.25, 0.4, 4.8, 6.5, 8.2, 20 and 34 μM at α3β4, α1β1εδ, α3β4β3, α6β4β3, α7, α4β2, α3β2β3 and α6/3β2β3 receptors respectively). Attenuates nicotine-evoked dopamine release from the ventral tegmental area in vivo (IC50 = 0.2 nM) and reduces nicotine self-administration in rats. Brain penetrant.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
N,N'alkane-diyl-bis-3-picoliniums as nicotinic receptor antagonists: Inhibition of nicotine-evoked DA release and hyperactivity.
Dwoskin et al.
Region-specific effects of the N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide on nicotine-induced increase in extracellular DA in vivo.
Rahman et al.
Bis-azaaromatic quaternary ammonium analogues: ligands for α4β2* and β7* subtypes of neuronal nicotinic receptors
Ayers et al.
Citation for bPiDDB
The citations listed below are publications that use Tocris products. Selected citations for bPiDDB include:
1 Citation: Showing 1 - 1
Pharmacologically distinct nicotinic acetylcholine receptors drive efferent-mediated excitation in calyx-bearing vestibular afferents.
Authors: Holt Et al.
J Cell Biol 2015;35:3625
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