Chemical Name: 1,4-Dihydro-1-[(4-methoxyphenyl)methyl]-4-oxo-3-quinolinecarboxylic acid
Biological ActivityMuscarinic M1 receptor positive allosteric modulator (pKB 5.76 - 5.82). Exhibits selectivity for M1 over M3 and M5 receptors. Enhances ACh effects at M1 receptors in an IP1- accumulation assay, without affecting ACh binding. Increases markers of neuronal activation in brains of wild-type but not M1-/- mice in vivo. Prevents Scopolamine (Cat. No. 1414)-induced memory deficits in mice in a contextual fear conditioning model.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Selective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiation.
Ma et al.
Probing the binding site of novel selective positive allosteric modulators at the M1 muscarinic acetylcholine receptor.
Khajehali et al.
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