Chemical Name: 1,6,7,8,9,11aβ,12,13,14,14αa-Decahydro-1β,13α-dihydroxy-6β-methyl-4H-cyclopent(f)oxacyclotridecin-4-one
Biological ActivityBrefeldin A is a reversible inhibitor of protein translocation from the endoplasmic reticulum (ER) to the Golgi apparatus. Blocks binding of ADP-ribosylation factor (ARF1) to the Golgi apparatus and inhibits GDP-GTP exchange. Can be used to induce autophagy in mammalian cells. Also enhances CRISPR-mediated homology-directed repair (HDR) efficiency ~2-fold when applied at 100 nM, in human induced pluripotent stem cells (iPSCs). Antifungal.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Small molecules enhance CRISPR genome editing in pluripotent stem cells.
Yu et al.
Cell Stem Cell, 2015;16:142
Differential effects of endoplasmic reticulum stress-induced autophagy on cell survival.
Ding et al.
Action of brefeldin A blocked by activation of a pertussis-toxin-sensitive G protein.
Ktistakis et al.
Isolation of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP ribosylation factor (ARF)1 and ARF3 that contains a Sec7-like domain.
Morinaga et al.
Identification of a brefeldin A-insensitive guanine nucleotide-exchange protein for ADP-ribosylation factor in bovine brain.
Tsai et al.
Citations for Brefeldin A
The citations listed below are publications that use Tocris products. Selected citations for Brefeldin A include:
10 Citations: Showing 1 - 10
Caspase-mediated cleavage of IRE1 controls apoptotic cell commitment during endoplasmic reticulum stress.
Authors: Shemorry Et al.
Mice Deficient in Nucleoporin Nup210 Develop Peripheral T Cell Alterations.
Authors: Nieuwenhuijze Et al.
Front Immunol 2018;9:2234
Hyperactivation of nuclear receptor coactivators induces PERK-dependent cell death.
Authors: Hossain Et al.
Systematic genetic mapping of necroptosis identifies SLC39A7 as modulator of death receptor trafficking.
Authors: Fauster Et al.
Cell Death Differ 2018;
Golgi-independent secretory trafficking through recycling endosomes in neuronal dendrites and spines.
Authors: Bowen Et al.
GADD34 function in protein trafficking promotes adaptation to hyperosmotic stress in human corneal cells.
Cell Rep 2017;21(10):2895
Rhinovirus-induced macrophage cytokine expression does not require endocytosis or replication.
Authors: Saba Et al.
Am J Respir Cell Mol Biol 2014;50:974
A novel mechanism for nicotinic potentiation of glutamatergic synapses.
Authors: Halff Et al.
J Neurosci 2014;34:2051
The expression and relaxant effect of bitter taste receptors in human bronchi.
Authors: Grassin-Delyle Et al.
Respir Res 2013;14:134
Concerted actions of NHERF2 and WNK4 in regulating TRPV5.
Authors: Jing Et al.
J Neurosci 2011;404:979
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