Reversible inhibitor of protein translocation from the endoplasmic reticulum (ER) to the Golgi apparatus. Blocks binding of ADP-ribosylation factor to the Golgi apparatus and inhibits GDP-GTP exchange. Can be used to induce autophagy in mammalian cells. Also enhances CRISPR-mediated homology-directed repair (HDR) efficiency ~2-fold when applied at 100 nM, in human induced pluripotent stem cells (iPSCs).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Small Molecules Enhance CRISPR Genome Editing in Pluripotent Stem Cells.
Yu et al.
Cell Stem Cell, 2015;16:142
Action of brefeldin A blocked by activation of a pertussis-toxin-sensitive G protein.
Ktistakis et al.
Isolation of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP ribosylation factor (ARF)1 and ARF3 that contains a Sec7-like domain.
Morinaga et al.
Differential effects of endoplasmic reticulum stress-induced autophagy on cell survival.
Ding et al.
Identification of a brefeldin A-insensitive guanine nucleotide-exchange protein for ADP-ribosylation factor in bovine brain.
Tsai et al.
The citations listed below are publications that use Tocris products. Selected citations for Brefeldin A include:
Showing Results 1 - 3 of 3