Brefeldin A

  ( 4 citations )    
Product Datasheet
Catalog Number:1231
Chemical Name:1,6,7,8,9,11aβ,12,13,14,14αa-Decahydro-1β,13α-dihydroxy-6β-methyl-4H-cyclopent(f)oxacyclotridecin-4-one
Product Details
Citations (4)
Reviews
Biological Activity
Reversible inhibitor of protein translocation from the endoplasmic reticulum (ER) to the Golgi apparatus. Blocks binding of ADP-ribosylation factor to the Golgi apparatus and inhibits GDP-GTP exchange. Can be used to induce autophagy in mammalian cells. Also enhances CRISPR-mediated homology-directed repair (HDR) efficiency ~2-fold when applied at 100 nM, in human induced pluripotent stem cells (iPSCs).
Technical Data
  • M.Wt:
    280.36
  • Formula:
    C16H24O4
  • Solubility:
    Soluble to 50 mM in DMSO and to 10 mM in ethanol
  • Purity:
    >98
  • Storage:
    Desiccate at -20°C
  • CAS No:
    20350-15-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Brefeldin A include:

4 Citations: Showing 1 - 4
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  1. GADD34 function in protein trafficking promotes adaptation to hyperosmotic stress in human corneal cells.
    Authors: Krokowski
    Cell Rep  2017;21(10):2895
  2. A novel mechanism for nicotinic potentiation of glutamatergic synapses.
    Authors: Halff Et al.
    J Neurosci  2014;34:2051
  3. The expression and relaxant effect of bitter taste receptors in human bronchi.
    Authors: Grassin-Delyle Et al.
    Respir Res  2013;14:134
  4. Concerted actions of NHERF2 and WNK4 in regulating TRPV5.
    Authors: Jing Et al.
    J Neurosci  2011;404:979

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