Brefeldin A

Catalog # Availability Size / Price Qty
1231/5

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Brefeldin A | CAS No. 20350-15-6 | Translocation, Exo/Endocytosis Products
1 Image
Description: Disrupts protein translocation to Golgi

Chemical Name: 1,6,7,8,9,11aβ,12,13,14,14aα-Decahydro-1β,13α-dihydroxy-6β-methyl-4H-cyclopent[f]oxacyclotridecin-4-one

Purity: ≥98%

Product Details
Citations (10)
Reviews

Biological Activity

Brefeldin A is a reversible inhibitor of protein translocation from the endoplasmic reticulum (ER) to the Golgi apparatus. Blocks binding of ADP-ribosylation factor (ARF1) to the Golgi apparatus and inhibits GDP-GTP exchange. Can be used to induce autophagy in mammalian cells. Also enhances CRISPR-mediated homology-directed repair (HDR) efficiency ~2-fold when applied at 100 nM, in human induced pluripotent stem cells (iPSCs). Antifungal.

Technical Data

M.Wt:
280.36
Formula:
C16H24O4
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
20350-15-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Brefeldin A

The citations listed below are publications that use Tocris products. Selected citations for Brefeldin A include:

10 Citations: Showing 1 - 10

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