Bryostatin 2

Name: Bryostatin 2
Brand: Tocris Bioscience
SKU: 5237

Catalog #: 5237 Datasheet / COA / SDS

Discontinued Product

5237 has been discontinued.

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Bryostatin 2 | CAS No. 87745-28-6 | Protein Kinase C Activators

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Description: Protein kinase C activator

Chemical Name: (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-1,11,21,25-Tetrahydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.1^3,7.1^11,15]nonacos-8-en-12-yl-(2E,4E)-2,4-octadienoic acid ester

Purity: ≥98%

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Product Details

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Biological Activity

Protein kinase C (PKC) activator; analog of Bryostatin 1 (Cat. No. 2383). Attenuates cell proliferation and cell attachment in U937 cells. Inhibits DNA synthesis at 100 nM in SH-SY5Y human neuroblastoma cells. Also inhibits EGF binding and induces arachidonic acid release in vitro. Antitumor.

Technical Data

M.Wt:

863

Formula:

C₄₅H₆₆O₁₆

Solubility:

Soluble in ethanol

Purity:

≥98%

Storage:

Store at -20°C

CAS No:

87745-28-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Comparison of effects of bryoSTAT 1 and 2 and 12-O-tetradecanoylphorbol-13-acetate on protein kinase C activity in A549 human lung carcinoma cells.
Dale et al.
Cancer Res., 1989;49:3242
Differential effects of bryoSTAT and phorbol esters on arachidonic acid metabolite release and epidermal growth factor binding in C3H 10T1/2 cells.
Dell'Aquila et al.
Cancer Res., 1988;48:3702
Effects of bryoSTAT 1 and 2 on morphological and functional differentiation of SH-SY5Y human neuroblastoma cells.
Jalava et al.
Cancer Res., 1990;50:3422
Comparison of transcriptional response to phorbol ester, bryostatin 1, and bryostatin analogs in LNCaP and U937 cancer cell lines provides insight into their differential mechanism of action.
Kedei et al.
Biochem Pharmacol., 2013;85:313

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