BX 513 hydrochloride

Key Product Details

Product Description

BX 513 hydrochloride is a selective CCR1 receptor antagonist (K_i values are 0.04, > 10, > 10 and > 10 nM for CCR1, CCR5, CXCR2 and CXCR4 receptors respectively). Inhibits MIP-1α-induced intracellular calcium mobilization (IC₅₀ = 2.5 μM). Also a full inverse agonist at US28, a HCMV-encoded chemokine receptor.

Product Specifications for BX 513 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for BX 513 hydrochloride

The following data is based on the product molecular weight 481.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.08 mL	10.39 mL	20.77 mL
5 mM	0.42 mL	2.08 mL	4.15 mL
10 mM	0.21 mL	1.04 mL	2.08 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Ng Discovery of a novel non-peptide CCR1 receptor antagonists. J.Med.Chem. 1999 PMID: 10579830
• Casarosa Identification of the first nonpeptidergic inverse agonist for a constitutively active viral-encoded G-protein-coupled receptor. J.Biol.Chem. 2003 PMID: 12456673
• Hesselgesser Identification and characterisation of small molecule functional antagonists of the CCR1 chemokine receptor. J.Biol.Chem. 1998 PMID: 9624164

Product Documents for BX 513 hydrochloride