Catalog Number: 2769
Alternate Names: VUF 2274
Chemical Name: 4-(4-Chlorophenyl)-4-hydroxy-α,α-diphenyl-1-piperidinepentanenitrile hydrochloride
Biological Activity
Selective CCR1 receptor antagonist (Ki values are 0.04, > 10, > 10 and > 10 nM for CCR1, CCR5, CXCR2 and CXCR4 receptors respectively). Inhibits MIP-1α-induced intracellular calcium mobilization (IC50 = 2.5 μM). Also a full inverse agonist at US28, a� HCMV-encoded chemokine receptor.
Technical Data
  • M.Wt:
    481.46
  • Formula:
    C28H29ClN2O.HCl
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    1216540-18-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Identification and characterisation of small molecule functional antagonists of the CCR1 chemokine receptor.
    Hesselgesser et al.
    J.Biol.Chem., 1998;273:15687
  2. Discovery of a novel non-peptide CCR1 receptor antagonists.
    Ng et al.
    J.Med.Chem., 1999;42:4680
  3. Identification of the first nonpeptidergic inverse agonist for a constitutively active viral-encoded G-protein-coupled receptor.
    Casarosa et al.
    J.Biol.Chem., 2003;278:5172

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