BX 513 hydrochloride

Catalog # Availability Size / Price Qty
2769/10
2769/50
BX 513 hydrochloride | CAS No. 1216540-18-9 | Chemokine Receptor Antagonists
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Description: Selective CCR1 antagonist
Alternative Names: VUF 2274

Chemical Name: 4-(4-Chlorophenyl)-4-hydroxy-α,α-diphenyl-1-piperidinepentanenitrile hydrochloride

Purity: ≥99%

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Biological Activity

Selective CCR1 receptor antagonist (Ki values are 0.04, > 10, > 10 and > 10 nM for CCR1, CCR5, CXCR2 and CXCR4 receptors respectively). Inhibits MIP-1α-induced intracellular calcium mobilization (IC50 = 2.5 μM). Also a full inverse agonist at US28, a HCMV-encoded chemokine receptor.

Technical Data

M.Wt:
481.46
Formula:
C28H29ClN2O.HCl
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥99%
Storage:
Desiccate at +4°C
CAS No:
1216540-18-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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