BX 513 hydrochloride

   
Product Datasheet
Catalog Number:2769
Alternate Names:VUF 2274
Chemical Name:4-(4-Chlorophenyl)-4-hydroxy-α,α-diphenyl-1-piperidinepentanenitrile hydrochloride
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Biological Activity
Selective CCR1 receptor antagonist (Ki values are 0.04, > 10, > 10 and > 10 nM for CCR1, CCR5, CXCR2 and CXCR4 receptors respectively). Inhibits MIP-1α-induced intracellular calcium mobilization (IC50 = 2.5 μM). Also a full inverse agonist at US28, a HCMV-encoded chemokine receptor.
Technical Data
  • M.Wt:
    481.46
  • Formula:
    C28H29ClN2O.HCl
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol
  • Purity:
    >99
  • Storage:
    Desiccate at +4°C
  • CAS No:
    1216540-18-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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