Chemical Name: N-[3-(Dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-(2-propenyl)ergoline-8-carboxamide
Biological ActivityCabergoline is a selective D2-like dopamine receptor agonist (Ki values are 0.7, 1.5, 9.0 and 165 nM for D2, D3, D4 and D5 receptors respectively) that also displays high affinity for several serotonin receptor subtypes (Ki = 1.2 - 20.0 nM for 5-HT1A, 5-HT1D, 5-HT2A and 5-HT2B). Inhibits secretion of prolactin and growth hormone and reverses levodopa-induced dyskinesias in Parkinsonian monkeys.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Effect of cabergoline, a DA agonist, on estrogen-induced rat pituitary tumors:in vitro culture studies.
Eguchi et al.
A review of the receptor-binding and pharmacokinetic properties of DA agonists.
Kvernmo et al.
Sustained caberg. treatment reverses levodopa-induced dyskinesias in parkinsonian monkeys.
Hadj Tahar et al.
Citations for Cabergoline
The citations listed below are publications that use Tocris products. Selected citations for Cabergoline include:
4 Citations: Showing 1 - 4
Expression of Stem Cell Markers and DA D2 Receptors in Human and Rat Prolactinomas.
Authors: Gao Et al.
Med Sci Monit 2017;23:1827
Activation of DRD5 inhibits tumor growth by autophagic cell death.
Authors: Leng Et al.
Suppression of mTOR pathway and induction of autophagy-dependent cell death by caberg.
Authors: Lin Et al.
PLoS One 2015;6:39329
Cabergoline, DA D2 receptor agonist, prevents neuronal cell death under oxidative stress via reducing excitotoxicity.
Authors: Odaka Et al.
J Biol Chem 2014;9:e99271
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