Cabergoline

Key Product Details

Product Description

Cabergoline is a selective D₂-like dopamine receptor agonist (K_i values are 0.7, 1.5, 9.0 and 165 nM for D₂, D₃, D₄ and D₅ receptors respectively) that also displays high affinity for several serotonin receptor subtypes (K_i = 1.2 - 20.0 nM for 5-HT_1A, 5-HT_1D, 5-HT_2A and 5-HT_2B). Inhibits secretion of prolactin and growth hormone and reverses levodopa-induced dyskinesias in Parkinsonian monkeys.

Product Specifications for Cabergoline

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Cabergoline

The following data is based on the product molecular weight 451.60.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.21 mL	11.07 mL	22.14 mL
5 mM	0.44 mL	2.21 mL	4.43 mL
10 mM	0.22 mL	1.11 mL	2.21 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 19 publications citing the usage of this product.

• Kvernmo A review of the receptor-binding and pharmacokinetic properties of DA agonists. Clin.Ther. 2006 PMID: 16982285
• Hadj Tahar Sustained caberg. treatment reverses levodopa-induced dyskinesias in parkinsonian monkeys. Cin.Neuropharmacol.
• Eguchi Effect of cabergoline, a DA agonist, on estrogen-induced rat pituitary tumors:in vitro culture studies. Endocr.J. 1995 PMID: 7670571

Product Documents for Cabergoline