Caspase-8 Inhibitor Z-IETD-FMK

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Citations (90)

Caspase-8 Inhibitor Z-IETD-FMK Summary

Cell permeable fluoromethyl ketone (FMK)-derivatized peptides act as effective irreversible Caspase inhibitors with no cytotoxic effects and, therefore, are useful tools for studying Caspase activity.


Shipping Conditions
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

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Background: Caspase-8

Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. They are expressed as latent zymogens and are activated by an autoproteolytic mechanism or by processing by other proteases (frequently other caspases). Human caspases can be subdivided into three functional groups: cytokine activation (caspase-1, -4, -5, and -13), apoptosis initiation (caspase-2, -8, -9, -and -10), and apoptosis execution (caspase-3, -6, and -7).

Caspases are regulated by a variety of stimili, including APAF1, CFLAR/FLIP, NOL3/ARC, and members of the inhibitor of apoptosis (IAP) family such as BIRC1/NAIP, BIRC2/cIAP-1, BIRC3/cIAP-2, BIRC4/XIAP, BIRC5/Survivin, and BIRC7/Livin. IAP activity is modulated by DIABLO/SMAC or PRSS25/HTRA2/Omi. Cell-permeable and irreversible peptide inhibitors are also available for different caspases.

Entrez Gene IDs
841 (Human); 12370 (Mouse)
Alternate Names
AIS; androgen receptor; CASP8; Caspase8; Caspase-8; DHTRTFM; Dihydrotestosterone receptorHYSP1; HUMARA; Mch5; NR3C4KD; Nuclear receptor subfamily 3 group C member 4; SMAX1SBMA; spinal and bulbar muscular atrophy

Citations for Caspase-8 Inhibitor Z-IETD-FMK

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

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  1. Caspase-8 inactivation drives autophagy-dependent inflammasome activation in myeloid cells
    Authors: YH Wu, ST Mo, IT Chen, FY Hsieh, SL Hsieh, J Zhang, MZ Lai
    Science Advances, 2022;8(45):eabn9912.  2022
  2. TRAF3/p38-JNK Signalling Crosstalk with Intracellular-TRAIL/Caspase-10-Induced Apoptosis Accelerates ROS-Driven Cancer Cell-Specific Death by CD40
    Authors: K Ibraheem, AMA Yhmed, MM Nasef, NT Georgopoul
    Cells, 2022;11(20):.  2022
  3. EV-A71 induced IL-1beta production in THP-1 macrophages is dependent on NLRP3, RIG-I, and TLR3
    Authors: HI Huang, CC Chio, JY Lin, CJ Chou, CC Lin, SH Chen, LS Yu
    Scientific Reports, 2022;12(1):21425.  2022
  4. Cell surface nucleolin is a novel ADAMTS5 receptor mediating endothelial cell apoptosis
    Authors: DC Kirman, B Renganatha, WK Chui, MW Chen, NA Kaya, R Ge
    Cell Death & Disease, 2022;13(2):172.  2022
  5. Cell death mechanisms induced by synergistic effects of halofuginone and artemisinin in colorectal cancer cells
    Authors: RH Gong, DJ Yang, HY Kwan, AP Lyu, GQ Chen, ZX Bian
    International Journal of Medical Sciences, 2022;19(1):175-185.  2022
  6. TNF-alpha synergises with IFN-gamma to induce caspase-8-JAK1/2-STAT1-dependent death of intestinal epithelial cells
    Authors: JA Woznicki, N Saini, P Flood, S Rajaram, CM Lee, P Stamou, A Skowyra, M Bustamante, K Regazzoni, N Crawford, SS McDade, DB Longley, P Aza-Blanc, F Shanahan, SA Zulquernai, J McCarthy, S Melgar, BL McRae, K Nally
    Cell Death & Disease, 2021;12(10):864.  2021
  7. Extracts of select endemic plants from the Republic of Mauritius exhibiting anti-cancer and immunomodulatory properties
    Authors: S Kauroo, J Govinden-S, VM Ranghoo-Sa, K Miranda, WE Cotham, MD Walla, M Nagarkatti, P Nagarkatti
    Scientific Reports, 2021;11(1):4272.  2021
  8. Evolutionary loss of inflammasomes in the Carnivora and implications for the carriage of zoonotic infections
    Authors: Z Digby, P Tourlomous, J Rooney, JP Boyle, B Bibo-Verdu, RJ Pickering, SJ Webster, TP Monie, LJ Hopkins, N Kayagaki, GS Salvesen, S Warming, L Weinert, CE Bryant
    Cell Reports, 2021;36(8):109614.  2021
  9. OSMI-1 Enhances TRAIL-Induced Apoptosis through ER Stress and NF-kappaB Signaling in Colon Cancer Cells
    Authors: SJ Lee, DE Lee, SY Choi, OS Kwon
    International Journal of Molecular Sciences, 2021;22(20):.  2021
  10. Caspase-Dependent HMGB1 Release from Macrophages Participates in Peripheral Neuropathy Caused by Bortezomib, a Proteasome-Inhibiting Chemotherapeutic Agent, in Mice
    Authors: M Tsubota, T Miyazaki, Y Ikeda, Y Hayashi, Y Aokiba, S Tomita, F Sekiguchi, D Wang, M Nishibori, A Kawabata
    Cells, 2021;10(10):.  2021
  11. N4BP1 negatively regulates NF-&kappaB by binding and inhibiting NEMO oligomerization
    Authors: H Shi, L Sun, Y Wang, A Liu, X Zhan, X Li, M Tang, P Anderton, S Hildebrand, J Quan, S Ludwig, EMY Moresco, B Beutler
    Nature Communications, 2021;12(1):1379.  2021
  12. Protective role of cytoplasmic p21Cip1/Waf1 in apoptosis of CDK4/6 inhibitor-induced senescence in breast cancer cells
    Authors: ID Kartika, H Kotani, Y Iida, A Koyanagi, R Tanino, M Harada
    Cancer Medicine, 2021;0(0):.  2021
  13. Targeting highly pathogenic coronavirus-induced apoptosis reduces viral pathogenesis and disease severity
    Authors: H Chu, H Shuai, Y Hou, X Zhang, L Wen, X Huang, B Hu, D Yang, Y Wang, C Yoon, BH Wong, C Li, X Zhao, VK Poon, JP Cai, KK Wong, ML Yeung, J Zhou, RK Au-Yeung, S Yuan, DY Jin, KH Kok, S Perlman, JF Chan, KY Yuen
    Science Advances, 2021;7(25):.  2021
  14. Role of JNK activation in paclitaxel-induced apoptosis in human head and neck squamous cell carcinoma
    Authors: YY Lan, YH Chen, C Liu, KL Tung, YT Wu, SC Lin, CH Wu, HY Chang, YC Chen, BM Huang
    Oncology Letters, 2021;22(4):705.  2021
  15. Sanguinarine Induces Apoptosis in Papillary Thyroid Cancer Cells via Generation of Reactive Oxygen Species
    Authors: AQ Khan, EAN Mohamed, I Hakeem, A Nazeer, S Kuttikrish, KS Prabhu, KS Siveen, Z Nawaz, A Ahmad, H Zayed, S Uddin
    Molecules, 2020;25(5):.  2020
  16. The mechanism of how CD95/Fas activates the Type I IFN/STAT1 axis, driving cancer stemness in breast cancer
    Authors: AS Qadir, AM Stults, AE Murmann, ME Peter
    Sci Rep, 2020;10(1):1310.  2020
  17. Osteogenic impact of pro-apoptotic caspase inhibitors in MC3T3-E1 cells
    Authors: A Kratochvíl, B Veselá, V Ledvina, E Švandová, K Klepárník, K Dadáková, P Beneš, E Matalová
    Sci Rep, 2020;10(1):7489.  2020
  18. The Pseudomonas aeruginosa protease LasB directly activates IL-1&beta
    Authors: J Sun, DL LaRock, EA Skowronski, JM Kimmey, J Olson, Z Jiang, AJ O'Donoghue, V Nizet, CN LaRock
    EBioMedicine, 2020;60(0):102984.  2020
  19. Involvement of the miR-137-3p/CAPN-2 Interaction in Ischemia-Reperfusion-Induced Neuronal Apoptosis through Modulation of p35 Cleavage and Subsequent Caspase-8 Overactivation
    Authors: H Wang, Q Yu, ZL Zhang, H Ma, XQ Li
    Oxidative Medicine and Cellular Longevity, 2020;2020(0):2616871.  2020
  20. Caspase Activation and Caspase-Mediated Cleavage of APP Is Associated with Amyloid beta-Protein-Induced Synapse Loss in Alzheimer's Disease
    Authors: G Park, HS Nhan, SH Tyan, Y Kawakatsu, C Zhang, M Navarro, EH Koo
    Cell Rep, 2020;31(13):107839.  2020
  21. Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells
    Authors: E Alharris, NP Singh, PS Nagarkatti, M Nagarkatti
    Oncotarget, 2019;10(1):45-59.  2019
  22. Deficiency in the DNA repair protein ERCC1 triggers a link between senescence and apoptosis in human fibroblasts and mouse skin
    Authors: DE Kim, MET Dollé, WP Vermeij, A Gyenis, K Vogel, JHJ Hoeijmaker, CD Wiley, AR Davalos, P Hasty, PY Desprez, J Campisi
    Aging Cell, 2019;0(0):e13072.  2019
  23. PLF-1 (Proliferin-1) Modulates Smooth Muscle Cell Proliferation and Development of Experimental Intimal Hyperplasia
    Authors: L Hu, Z Huang, H Ishii, H Wu, S Suzuki, A Inoue, W Kim, H Jiang, X Li, E Zhu, L Piao, G Zhao, Y Lei, K Okumura, GP Shi, T Murohara, M Kuzuya, XW Cheng
    J Am Heart Assoc, 2019;8(24):e005886.  2019
  24. Genetic Screen in Chlamydia muridarum Reveals Role for an Interferon-Induced Host Cell Death Program in Antimicrobial Inclusion Rupture
    Authors: AM Giebel, S Hu, K Rajaram, R Finethy, E Toh, JA Brothwell, SG Morrison, RJ Suchland, BD Stein, J Coers, RP Morrison, DE Nelson
    MBio, 2019;10(2):.  2019
  25. BRD9 binds cell type-specific chromatin regions regulating leukemic cell survival via STAT5 inhibition
    Authors: N Del Gaudio, A Di Costanz, NQ Liu, L Conte, A Migliaccio, M Vermeulen, JHA Martens, HG Stunnenber, A Nebbioso, L Altucci
    Cell Death Dis, 2019;10(5):338.  2019
  26. Eukaryotic initiation factor 5B (eIF5B) provides a critical cell survival switch to glioblastoma cells via regulation of apoptosis
    Authors: JA Ross, KV Dungen, KR Bressler, M Fredriksen, D Khandige S, N Balasingam, N Thakor
    Cell Death Dis, 2019;10(2):57.  2019
  27. Combination therapy with proteasome inhibitors and TLR agonists enhances tumour cell death and IL-1? production
    Authors: AC Tang, SM Rahavi, SY Fung, HY Lu, H Yang, CJ Lim, GS Reid, SE Turvey
    Cell Death Dis, 2018;9(2):162.  2018
  28. Targeting the ER-mitochondria interface sensitizes leukemia cells towards cytostatics
    Authors: F Koczian, O Nag?o, J Vomacka, B Vick, P Servatius, T Zisis, B Hettich, U Kazmaier, SA Sieber, I Jeremias, S Zahler, S Braig
    Haematologica, 2018;0(0):.  2018
  29. Ceramide synthase-6 confers resistance to chemotherapy by binding to CD95/Fas in T-cell acute lymphoblastic leukemia
    Authors: D Verlekar, SJ Wei, H Cho, S Yang, MH Kang
    Cell Death Dis, 2018;9(9):925.  2018
  30. Bacterial Pore-Forming Toxins Promote the Activation of Caspases in Parallel to Necroptosis to Enhance Alarmin Release and Inflammation During Pneumonia
    Authors: N Gonzalez-J, KM Bradley, AN Riegler, LF Reyes, T Brissac, SS Park, MI Restrepo, CJ Orihuela
    Sci Rep, 2018;8(1):5846.  2018
  31. Targeting CDK1 and MEK/ERK Overcomes Apoptotic Resistance in BRAF Mutated human Colorectal Cancer
    Authors: P Zhang, H Kawakami, W Liu, X Zeng, K Strebhardt, K Tao, S Huang, FA Sinicrope
    Mol. Cancer Res., 2017;0(0):.  2017
  32. Production and regulation of interleukin-1 family cytokines at the materno-fetal interface
    Authors: LM Scott, AH Bryant, A Rees, B Down, RH Jones, CA Thornton
    Cytokine, 2017;0(0):.  2017
  33. Specific pathways mediating inflammasome activation by Candida parapsilosis
    Authors: A Tóth, E Zajta, K Csonka, C Vágvölgyi, MG Netea, A Gácser
    Sci Rep, 2017;7(0):43129.  2017
  34. Suberoylanilide hydroxamic acid increases anti-cancer effect of tumor necrosis factor-? through up-regulation of TNF receptor 1 in lung cancer cells.
    Authors: Bo Ra You, Bo Ram Han, Woo Hyun Park
    Oncotarget, 2017;0(0):1949-2553.  2017
  35. Polymeric mechanical amplifiers of immune cytokine-mediated apoptosis
    Authors: MJ Mitchell, J Webster, A Chung, PP Guimarães, OF Khan, R Langer
    Nat Commun, 2017;8(0):14179.  2017
  36. Shikonin-induced necroptosis is enhanced by the inhibition of autophagy in non-small cell lung cancer cells
    Authors: HJ Kim, KE Hwang, DS Park, SH Oh, HY Jun, KH Yoon, ET Jeong, HR Kim, YS Kim
    J Transl Med, 2017;15(1):123.  2017
  37. Dual role of DR5 in death and survival signaling leads to TRAIL resistance in cancer cells
    Authors: Y Shlyakhtin, V Pavet, H Gronemeyer
    Cell Death Dis, 2017;8(8):e3025.  2017
  38. Synergistic Antitumour Properties of viscumTT in Alveolar Rhabdomyosarcoma
    Authors: RM Stammer, S Kleinsimon, J Rolff, S Jäger, A Eggert, G Seifert, CI Delebinski
    J Immunol Res, 2017;2017(0):4874280.  2017
  39. Combination Therapy With c-Met and Src Inhibitors Induces Caspase-Dependent Apoptosis of Merlin-Deficient Schwann Cells and Suppresses Growth of Schwannoma Cells
    Authors: MA Fuse, S Klingeman, SS Burns, CT Dinh, O Bracho, D Yan, R Mittal, R Shen, JN Soulakova, AJ Copik, XZ Liu, FF Telischi, LS Chang, MC Franco, C Fernandez-
    Mol. Cancer Ther., 2017;0(0):.  2017
  40. Caspase-1 Engagement and TLR-Induced c-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b and NLRC4
    Authors: N Van Opdenb, H Van Gorp, M Verdonckt, PHV Saavedra, NM de Vasconc, A Gonçalves, L Vande Wall, D Demon, M Matusiak, F Van Hauwer, J D'Hont, T Hochepied, S Krautwald, TD Kanneganti, M Lamkanfi
    Cell Rep, 2017;21(12):3427-3444.  2017
  41. Epidermal Rac1 regulates the DNA damage response and protects from UV-light-induced keratinocyte apoptosis and skin carcinogenesis
    Authors: J Deshmukh, R Pofahl, I Haase
    Cell Death Dis, 2017;8(3):e2664.  2017
  42. Therapeutic targeting of necroptosis by Smac mimetic bypasses apoptosis resistance in acute myeloid leukemia cells
    Oncogene, 2016;0(0):.  2016
  43. Lipopolysaccharide (LPS) Promotes Apoptosis in Human Breast Epithelial x Breast Cancer Hybrids, but Not in Parental Cells.
    Authors: Fried S, Tosun S, Troost G, Keil S, Zaenker K, Dittmar T
    PLoS ONE, 2016;11(2):e0148438.  2016
  44. IL-1? is an innate immune sensor of microbial proteolysis
    Authors: CN LaRock, J Todd, DL LaRock, J Olson, AJ O'Donoghue, AA Robertson, MA Cooper, HM Hoffman, V Nizet
    Sci Immunol, 2016;1(2):.  2016
  45. Hepatitis C Virus Infection of Cultured Human Hepatoma Cells Causes Apoptosis and Pyroptosis in Both Infected and Bystander Cells
    Sci Rep, 2016;6(0):37433.  2016
  46. Local anesthetic bupivacaine induced ovarian and prostate cancer apoptotic cell death and underlying mechanisms in vitro
    Sci Rep, 2016;6(0):26277.  2016
  47. Stage-specific embryonic antigen-3 (SSEA-3) and beta3GalT5 are cancer specific and significant markers for breast cancer stem cells.
    Authors: Cheung S, Chuang P, Huang H, Hwang-Verslues W, Cho C, Yang W, Shen C, Hsiao M, Hsu T, Chang C, Wong C
    Proc Natl Acad Sci U S A, 2016;113(4):960-5.  2016
  48. The Role of Prostate Apoptosis Response-4 (Par-4) in Mycobacterium tuberculosis Infected Macrophages
    Sci Rep, 2016;6(0):32079.  2016
  49. Heterogeneous Nuclear Ribonucleoprotein L is required for the survival and functional integrity of murine hematopoietic stem cells
    Authors: Marie-Claude Gaudreau
    Sci Rep, 2016;6(0):27379.  2016
  50. Macrophage Apoptosis Triggered by IpaD from Shigella flexneri
    Authors: O Arizmendi, WD Picking, WL Picking
    Infect Immun, 2016;0(0):.  2016
  51. Heparan Sulfate Proteoglycans Are Important for Islet Amyloid Formation and Islet Amyloid Polypeptide-induced Apoptosis.
    Authors: Oskarsson M, Singh K, Wang J, Vlodavsky I, Li J, Westermark G
    J Biol Chem, 2015;290(24):15121-32.  2015
  52. Caspase-8 as an Effector and Regulator of NLRP3 Inflammasome Signaling.
    Authors: Antonopoulos C, Russo H, El Sanadi C, Martin B, Li X, Kaiser W, Mocarski E, Dubyak G
    J Biol Chem, 2015;290(33):20167-84.  2015
  53. Source and Purity of Dengue-Viral Preparations Impact Requirement for Enhancing Antibody to Induce Elevated IL-1beta Secretion: A Primary Human Monocyte Model.
    Authors: Callaway J, Smith S, Widman D, McKinnon K, Scholle F, Sempowski G, Dittmer D, Crowe J, de Silva A, Ting J
    PLoS ONE, 2015;10(8):e0136708.  2015
  54. A dual role for Caspase8 and NF-?B interactions in regulating apoptosis and necroptosis of ovarian cancer, with correlation to patient survival
    Authors: L Hernandez, MK Kim, AM Noonan, E Sagher, H Kohlhammer, G Wright, LT Lyle, PS Steeg, M Anver, DD Bowtell,, CM Annunziata
    Cell Death Discov, 2015;1(0):15053.  2015
  55. Pore-Forming Toxins Induce Macrophage Necroptosis during Acute Bacterial Pneumonia.
    Authors: Gonzalez-Juarbe N, Gilley R, Hinojosa C, Bradley K, Kamei A, Gao G, Dube P, Bergman M, Orihuela C
    PLoS Pathog, 2015;11(12):e1005337.  2015
  56. Induction of caspase-dependent apoptosis by apigenin by inhibiting STAT3 signaling in HER2-overexpressing MDA-MB-453 breast cancer cells.
    Authors: Seo H, Ku J, Choi H, Woo J, Jang B, Shin Y, Ko S
    Anticancer Res, 2014;34(6):2869-82.  2014
  57. Anti-apoptotic effect of caspase inhibitors on H(2)O(2)-treated HeLa cells through early suppression of its oxidative stress.
    Authors: Park W
    Oncol Rep, 2014;31(5):2413-21.  2014
  58. MUC16 mucin (CA125) attenuates TRAIL-induced apoptosis by decreasing TRAIL receptor R2 expression and increasing c-FLIP expression.
    Authors: Matte I, Lane D, Boivin M, Rancourt C, Piche A
    BMC Cancer, 2014;14(0):234.  2014
  59. Luteolin induces intrinsic apoptosis via inhibition of E6/E7 oncogenes and activation of extrinsic and intrinsic signaling pathways in HPV-18-associated cells.
    Authors: Ham S, Kim K, Kwon T, Bak Y, Lee D, Song Y, Park S, Park Y, Kim M, Kang J, Hong J, Yoon D
    Oncol Rep, 2014;31(6):2683-91.  2014
  60. Transfection of poly(I:C) can induce reactive oxygen species-triggered apoptosis and interferon-beta-mediated growth arrest in human renal cell carcinoma cells via innate adjuvant receptors and the 2-5A system.
    Authors: Harashima N, Minami T, Uemura H, Harada M
    Mol Cancer, 2014;13(0):217.  2014
  61. Suberoylanilide hydroxamic acid-induced HeLa cell death is closely correlated with oxidative stress and thioredoxin 1 levels.
    Authors: You B, Park W
    Int J Oncol, 2014;44(5):1745-55.  2014
  62. Dengue viral protease interaction with NF-kappaB inhibitor alpha/beta results in endothelial cell apoptosis and hemorrhage development.
    Authors: Lin J, Lin S, Chen W, Yen Y, Lai C, Tao M, Lin Y, Miaw S, Wu-Hsieh B
    J Immunol, 2014;193(3):1258-67.  2014
  63. Phloroglucinol induces apoptosis via apoptotic signaling pathways in HT-29 colon cancer cells.
    Authors: Kang M, Kim I, Nam T
    Oncol Rep, 2014;32(4):1341-6.  2014
  64. Apoptosis and pro-inflammatory cytokine response of mast cells induced by influenza A viruses.
    Authors: Liu B, Meng D, Wei T, Zhang S, Hu Y, Wang M
    PLoS ONE, 2014;9(6):e100109.  2014
  65. 5-Fluorouracil-induced apoptosis in colorectal cancer cells is caspase-9-dependent and mediated by activation of protein kinase C-delta
    Authors: Mhaidat N, Bouklihacene M, Thorne R
    Oncol Lett, 2014;8(2):699-704.  2014
  66. Purified vitexin compound 1 induces apoptosis through activation of FOXO3a in hepatocellular carcinoma.
    Authors: Wang, Jian-Gan, Zheng, Xing-Xin, Zeng, Guang-Ya, Zhou, Ying-Jun, Yuan, Hong
    Oncol Rep, 2014;31(1):488-96.  2014
  67. How liposomal Cisplatin overcomes chemoresistance in ovarian tumour cells.
    Anticancer Res, 2014;34(1):525-30.  2014
  68. PX-12 inhibits the growth of A549 lung cancer cells via G2/M phase arrest and ROS-dependent apoptosis.
    Authors: You B, Shin H, Park W
    Int J Oncol, 2014;44(1):301-8.  2014
  69. TRAIL enhances apoptosis of human hepatocellular carcinoma cells sensitized by hepatitis C virus infection: therapeutic implications.
    Authors: Jang, Jae Youn, Kim, Seong-Ju, Cho, Eun Kyun, Jeong, Soung Wo, Park, Eui Ju, Lee, Woong Ch, Lee, Sae Hwan, Kim, Sang Gyu, Kim, Young Se, Kim, Hong Soo, Kim, Boo Sung, Lin, Wenyu, Chung, Raymond
    PLoS ONE, 2014;9(6):e98171.  2014
  70. PX-12-induced HeLa cell death is associated with oxidative stress and GSH depletion.
    Authors: Shin H, You B, Park W
    Oncol Lett, 2013;6(6):1804-1810.  2013
  71. Valproic acid inhibits the growth of HeLa cervical cancer cells via caspase-dependent apoptosis.
    Authors: Han B, You B, Park W
    Oncol Rep, 2013;30(6):2999-3005.  2013
  72. HOCl-dependent singlet oxygen and hydroxyl radical generation modulate and induce apoptosis of malignant cells.
    Authors: Bauer G
    Anticancer Res, 2013;33(9):3589-602.  2013
  73. The novel carboxamide analog ITR-284 induces caspase-dependent apoptotic cell death in human hepatocellular and colorectal cancer cells.
    Authors: Liao Y, Lu C, Lai K, Yang J, Kuo S, Wen Y, Fushiya S, Wu T
    Mol Med Rep, 2013;7(5):1539-44.  2013
  74. NLRP3 inflammasome activation by Paracoccidioides brasiliensis.
    Authors: Tavares A, Magalhaes K, Almeida R, Correa R, Burgel P, Bocca A
    PLoS Negl Trop Dis, 2013;7(12):e2595.  2013
  75. Brahma is essential for Drosophila intestinal stem cell proliferation and regulated by Hippo signaling.
    Authors: Jin, Yunyun, Xu, Jinjin, Yin, Meng-Xin, Lu, Yi, Hu, Lianxin, Li, Peixue, Zhang, Peng, Yuan, Zengqian, Ho, Margaret, Ji, Hongbin, Zhao, Yun, Zhang, Lei
    Elife, 2013;2(0):e00999.  2013
  76. Casticin potentiates TRAIL-induced apoptosis of gastric cancer cells through endoplasmic reticulum stress.
    Authors: Zhou Y, Tian L, Long L, Quan M, Liu F, Cao J
    PLoS ONE, 2013;8(3):e58855.  2013
  77. TAK1 is essential for osteoclast differentiation and is an important modulator of cell death by apoptosis and necroptosis.
    Authors: Lamothe B, Lai Y, Xie M, Schneider M, Darnay B
    Mol Cell Biol, 2013;33(3):582-95.  2013
  78. Zoledronic acid significantly enhances radiationinduced apoptosis against human fibrosarcoma cells by inhibiting radioadaptive signaling.
    Authors: Koto K, Murata H, Kimura S, Sawai Y, Horie N, Matsui T, Ryu K, Ashihara E, Maekawa T, Kubo T, Fushiki S
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  79. Drozitumab, a human antibody to death receptor 5, has potent antitumor activity against rhabdomyosarcoma with the expression of caspase-8 predictive of response.
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  80. Astrocyte and muscle-derived secreted factors differentially regulate motoneuron survival.
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  81. Protective effects of neurotrophic factors on tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis of murine adrenal chromaffin cell line tsAM5D.
    Authors: Murata T, Tsuboi M, Hikita K, Kaneda N
    J. Biol. Chem., 2006;281(32):22503-16.  2006
  82. Acquired resistance to TRAIL-induced apoptosis in human ovarian cancer cells is conferred by increased turnover of mature caspase-3.
    Authors: Lane D, Cote M, Grondin R, Couture MC, Piche A
    Mol. Cancer Ther., 2006;5(3):509-21.  2006
  83. Mechanism of induction of pancreatic acinar cell apoptosis by hydrogen sulfide.
    Authors: Cao Y, Adhikari S, Ang AD, Moore PK, Bhatia M
    Am. J. Physiol., Cell Physiol., 2006;291(3):C503-10.  2006
  84. Functional proteomics of resveratrol-induced colon cancer cell apoptosis: caspase-6-mediated cleavage of lamin A is a major signaling loop.
    Authors: Lee SC, Chan J, Clement MV, Pervaiz S
    Proteomics, 2006;6(8):2386-94.  2006
  85. HIV-1 tat protein and cell proliferation and survival: a brief review.
    Authors: Gibellini D, Vitone F, Schiavone P, Re MC
    New Microbiol., 2005;28(2):95-109.  2005
  86. Increased sensitivity of early apoptotic cells to complement-mediated lysis.
    Authors: Attali G, Gancz D, Fishelson Z
    Eur. J. Immunol., 2004;34(11):3236-45.  2004
  87. Synergistic induction of apoptosis in breast cancer cells by cotreatment with butyrate and TNF-alpha, TRAIL, or anti-Fas agonist antibody involves enhancement of death receptors' signaling and requires P21(waf1).
    Authors: Chopin V, Slomianny C, Hondermarck H, Le Bourhis X
    Exp. Cell Res., 2004;298(2):560-73.  2004
  88. RGDS peptide induces caspase 8 and caspase 9 activation in human endothelial cells.
    Authors: Aguzzi MS, Giampietri C, De Marchis F, Padula F, Gaeta R, Ragone G, Capogrossi MC, Facchiano A
    Blood, 2004;103(11):4180-7.  2004
  89. Study of caspase inhibitors for limiting death in mammalian cell culture.
    Authors: Sauerwald TM, Oyler GA, Betenbaugh MJ
    Biotechnol. Bioeng., 2003;81(3):329-40.  2003
  90. Targeting hypoxia-induced tumor stemness by activating pathogen-induced stem cell niche defense.
    Authors: Bhuyan S, Pal B, Pathak L, Saikia P, Mitra S, Gayan S, Mokhtari R, Li H, Ramana C, Baishya D, Das B
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  1. Does R&D Systems offer a negative control for Caspase Inihibitors with benzyloxycarbonyl group (Z-) at the N-terminus and the FMK functional group at the C-terminus?

    • Yes, R&D Systems offers Caspase Inhibitor Control Z-FA-FMK, Catalog # FMKC01, which is an inhibitor of cathepsins B and L but not caspases, and has been used in several systems as a negative control for peptide inhibitors of caspases.

  2. Are R&D Systems Caspase Inhibitors irreversible?

    • Yes, the majority of R&D Systems Caspase Inhibitors have a Fluoromethyl ketone (FMK) functional group on the C-terminus of the peptide, and act as effective irreversible inhibitors with no added cytotoxic effects. Inhibitors synthesized with a benzyloxycarbonyl group (also known as BOC or Z) at the N-terminus and O-methyl side chains exhibit enhanced cellular permeability.

      R&D Systems also offers a General Caspase Inhibitor, Q-VD-OPh, Catalog # OPH001, as well as a FITC-conjugated pan-caspase inhibitor (ApoStat), Catalog # FMK012, which are both cell-permeable, irreversible inhibitors of caspase activity.

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