CD14 Antibody (TUK4) [Biotin]

Name: CD14 Antibody (TUK4) [Biotin]
Brand: Novus Biologicals
SKU: NB100-62994B
Price: 539 USD
Availability: InStock

Novus Biologicals | Catalog # NB100-62994B

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Product Documents

Clone TUK4 was used by HLDA to establish CD designation.

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Product Specifications
Applications
Flow Cytometry
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species Reactivity

Human

Applications

ELISA, Flow Cytometry

Label

Biotin

Antibody Source

Monoclonal Mouse IgG_2A Clone # TUK4

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Product Specifications

Immunogen

Made to Human CD14

Reactivity Notes

Predicted cross-reactivities: Rabbit, Porcine, Feline, Cynomolgus monkey, Dog, Bovine, Llama, Mink, Goat, Sheep

Localization

Cell Membrane

Specificity

This product recognises the human CD14 cell surface antigen, expressed strongly by most peripheral blood monocytes and weakly on granulocytes. Clone Tuk4 has been shown to block SDF-induced chemotaxis of U937 cells in a dose-dependent manner(6).

Clonality

Monoclonal

Host

Mouse

Isotype

IgG_2A

Applications for CD14 Antibody (TUK4) [Biotin]

Application

Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Application Notes

Optimal dilution of this antibody should be experimentally determined.

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Advanced Features

Spectra Viewer - Custom analysis of spectra from multiple fluorochromes
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Antigen Density Selector - Match fluorochrome brightness with antigen density

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Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: CD14

CD14 is a 53-55 kD glycosylphosphatidylinositol (GPI)-linked membrane glycoprotein also known as LPS receptor. CD14 is expressed at high levels on monocytes and macrophages, and at lower levels on granulocytes. Some dendritic cell populations such as interfollicular dendritic cells, reticular dendritic cells, and Langerhans cells have also been reported to express CD14. As a high-affinity receptor for LPS, CD14 is involved in the clearance of gram-negative pathogens and in the upregulation of adhesion molecules and cytokines expression in monocytes and neutrophils. The M5E2 antibody inhibits monocyte activation and cytokine production induced by LPS.

Alternate Names

CD14

Gene Symbol

CD14

Additional CD14 Products

Product Documents for CD14 Antibody (TUK4) [Biotin]

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Product Specific Notices for CD14 Antibody (TUK4) [Biotin]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.