Catalog Number: 0271
Chemical Name: cis-1-Aminocyclobutane-1,3-dicarboxylic acid
Biological Activity
Potent, competitive and selective inhibitor of glutamate uptake. Certain confusion exists over the naming of this compound because of apparent contradictions in the literature. This is the isomer which has the carboxylic acid and the amino groups on the same side of the cyclobutyl ring.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in 1eq. NaOH
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Synthesis and activity of a potent NMDA agonist, trans-1-aminocyclobutane-1,3-dicarboxylic acid, and related phosphonic and carboxylic acids.
    Allan et al.
    J.Med.Chem., 1990;33:2905
  2. Inhibition of L-glutamic acid uptake into rat cortical synaptosomes by the conformationally restricted analogue of glutamic acid, cis-1-aminocyclobutane-1,3-dicarboxylic acid.
    Fletcher et al.
    Neurosci.Lett., 1991;121:133
  3. Differentiation of substrate and nonsubstrate inhibitors of the high-affinity, sodium-dependent glutamate transporters.
    Koch et al.
    Mol.Pharmacol., 1999;56:1095

The citations listed below are publications that use Tocris products. Selected citations for cis-ACBD include:

Showing Results 1 - 1 of 1

  1. Characterisation of the expression of NMDA receptors in human astrocytes.
    Authors: Lee Et al.
    PLoS One
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