1:1 mixture of (1R
)- and (1S
)-ACPD. Potent NMDA receptor agonist and selective group II mGluR agonist (EC50
values are 13, 50, >300 and >300 μ
M at mGluR2
respectively). Exhibits proconvulsant activity in vivo
(Cat. No. 0187) and (1S,3R)-ACPD
(Cat. No. 0284) also available.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Other Product-Specific Information:
Synthesis and pharmacology of 3-hydroxy-Δ2-isoxazoline-cyclopentane analogues of glutamic acid.
Conti et al.
In vitro and in vivo pharmacology of trans- and cis-(±)-1-amino-1,3-cyclopentanedicarboxylic acid: Dissociation of metabotropic and ionotropic excitatory amino acid receptor effects.
Schoepp et al.
Actions of the four isomers of 1-aminocyclopentane-1,3-dicarboxylate (ACPD) in the hemisected spinal cord of the neonatal rat.
Sunter et al.