Catalog Number: 0186
Chemical Name: (±)-1-Aminocyclopentane-cis-1,3-dicarboxylic acid
Biological Activity
1:1 mixture of (1R,3R)- and (1S,3S)-ACPD. Potent NMDA receptor agonist and selective group II mGluR agonist (EC50 values are 13, 50, >300 and >300 μM at mGluR2, mGluR4, mGluR1 and mGluR5 respectively). Exhibits proconvulsant activity in vivo.

(±)-trans-ACPD and (1S,3R)-ACPD also available.

Technical Data
  • M.Wt:
    173.17
  • Formula:
    C7H11NO4
  • Solubility:
    Soluble to 100 mM in 1eq. NaOH
  • Storage:
    Store at RT
  • CAS No:
    477331-06-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Synthesis and pharmacology of 3-hydroxy-Δ2-isoxazoline-cyclopentane analogues of glutamic acid.
    Conti et al.
    Farmaco, 2002;57:889
  2. In vitro and in vivo pharmacology of trans- and cis-(±)-1-amino-1,3-cyclopentanedicarboxylic acid: Dissociation of metabotropic and ionotropic excitatory amino acid receptor effects.
    Schoepp et al.
    J.Neurochem., 1991;56:1789
  3. Actions of the four isomers of 1-aminocyclopentane-1,3-dicarboxylate (ACPD) in the hemisected spinal cord of the neonatal rat.
    Sunter et al.
    Br.J.Pharmacol., 1991;104:337P

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