Compound E
Chemical Name: N-[(1S)-2-[[(3S)-2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide
Purity: ≥98%
Biological Activity
Compound E is a γ-secretase and notch patchway inhibitor. Compound E enhances growth inhibition, differentiation and migration of neuroblastoma cells when used in a combination with DAPT (Cat. No. 2634) and 13-cis RA. In combination with hLIF, CHIR 99021 (Cat. No. 4423) and SB 431542 (Cat. No. 1614), Compound E accelerates the induction of a homogeneous, self-renewing primitive neuroepithelium population from hESCs. Compound E is active in vitro and in vivo.For more information about how Compound E may be used, see our protocol: Generation of β cells from hPSCs
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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Background References
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Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors.
Li et al.
Proc.Natl.Acad.Sci.USA, 2011;108:8299 -
Targeting Notch pathway induces growth inhibition and differentiation of neuroblastoma cells.
Ferrari-Toninelli et al.
Neuro.Oncol., 2010;12:1231 -
Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology.
Beher et al.
J.Biol.Chem., 2001;276:45394
Product Datasheets
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Citations for Compound E
The citations listed below are publications that use Tocris products. Selected citations for Compound E include:
2 Citations: Showing 1 - 2
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Pancreatic islet cryopreservation by vitrification achieves high viability, function, recovery and clinical scalability for transplantation.
Authors: Zhan Et al.
Nat.Med. 2022;28:798
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A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation.
Authors: Sheng Et al.
Nat Commun 2018;9:4047
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