Compound E

Catalog # Availability Size / Price Qty
Compound E | CAS No. 209986-17-4 | Secretase Inhibitors
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Description: γ-secretase inhibitor; induces neuronal differentiation

Chemical Name: N-[(1S)-2-[[(3S)-2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide

Purity: ≥98%

Product Details
Citations (1)

Biological Activity

γ-secretase inhibitor. Enhances growth inhibition, differentiation and migration of neuroblastoma cells when used in a combination with DAPT (Cat. No. 2634) and 13-cis RA. In combination with hLIF, CHIR 99021 (Cat. No. 4423) and SB 431542 (Cat.No. 1614), accelerates the induction of a homogeneous, self-renewing primitive neuroepithelium population from hESCs. Active in vitro and in vivo.

Technical Data

Soluble to 100 mM in DMSO
Store at -20°C

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Citation for Compound E

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