Compound E

Catalog # Availability Size / Price Qty
6476/1
Cat.No. 6476 - Compound E | C27H24F2N4O3 | CAS No. 209986-17-4
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Description: γ-secretase inhibitor; induces neuronal differentiation

Chemical Name: N-[(1S)-2-[[(3S)-2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide

Purity: ≥98%

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Biological Activity

γ-secretase inhibitor. Enhances growth inhibition, differentiation and migration of neuroblastoma cells when used in a combination with DAPT (Cat. No. 2634) and 13-cis RA. In combination with hLIF, CHIR 99021 (Cat. No. 4423) and SB 431542 (Cat.No. 1614), accelerates the induction of a homogeneous, self-renewing primitive neuroepithelium population from hESCs. Active in vitro and in vivo.

Technical Data

M.Wt:
490.5
Formula:
C27H24F2N4O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
209986-17-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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