Chemical Name: N-[(1S)-2-[[(3S)-2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide
Biological Activityγ-secretase inhibitor. Enhances growth inhibition, differentiation and migration of neuroblastoma cells when used in a combination with DAPT (Cat. No. 2634) and 13-cis RA. In combination with hLIF, CHIR 99021 (Cat. No. 4423) and SB 431542 (Cat.No. 1614), accelerates the induction of a homogeneous, self-renewing primitive neuroepithelium population from hESCs. Active in vitro and in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors.
Li et al.
Targeting Notch pathway induces growth inhibition and differentiation of neuroblastoma cells.
Ferrari-Toninelli et al.
Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology.
Beher et al.
Citation for Compound E
The citations listed below are publications that use Tocris products. Selected citations for Compound E include:
1 Citation: Showing 1 - 1
A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation.
Authors: Sheng Et al.
Nat Commun 2018;9:4047
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