Inhibitor of γ
-secretase; causes a reduction in Aβ
40 and Aβ
42 levels in human primary neuronal cultures (IC50
values are 115 and 200 nM for total Aβ
42 respectively) and in brain extract, cerebrospinal fluid and plasma in vivo
. Does not affect APPα
levels. Blocks Notch signaling in hybrid human-mouse fetal thymus organ culture (FTOC). Activity causes ESCs to commit to neuronal differentiation.
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All Tocris products are intended for laboratory research use only.
Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain.
Dovey et al.
Different thresholds of notch signaling bias human precursor cells towards B-, NK-, monocytic/dendritic, or T-cell lineage in thymus microenvironment.
De Smedt et al.
The notch response inhibitor DAPT enhances neuronal differentiation in embryonic stem cell-derived embryoid bodies independently of sonic hedgehog signaling.
Crawford and Roelink
The citations listed below are publications that use Tocris products. Selected citations for DAPT include:
Showing Results 1 - 10 of 24