DAPT

  ( 34 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:2634
Chemical Name:(2S)-N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine 1,1-dimethylethyl ester
Product Details
Citations (34)
Reviews
Biological Activity
Inhibitor of γ-secretase; causes a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures (IC50 values are 115 and 200 nM for total Aβ and Aβ42 respectively) and in brain extract, cerebrospinal fluid and plasma in vivo. Does not affect APPα and APPβ levels. Blocks Notch signaling in hybrid human-mouse fetal thymus organ culture (FTOC). Activity causes ESCs to commit to neuronal differentiation.
Technical Data
  • M.Wt:
    432.46
  • Formula:
    C23H26F2N2O4
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at +4°C
  • CAS No:
    208255-80-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for DAPT include:

34 Citations: Showing 1 - 10
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  1. ErbB4 signaling stimulates pro-inflammatory macrophage apoptosis and limits colonic inflammation.
    Authors: Schumacher
    Cell Death Dis  2017;8:e2622
  2. Specification of murine ground state pluripotent stem cells to regional neuronal populations.
    Authors: Alsanie
    Sci Rep  2017;7(1):16001
  3. Soluble Gamma-secretase Modulators Attenuate Alzheimer's β-amyloid Pathology and Induce Conformational Changes in Presenilin 1.
    Authors: Raven Et al.
    EBioMedicine  2017;24:93
  4. A modular platform for differentiation of human PSCs into all major ectodermal lineages.
    Authors: Tchieu Et al.
    Cell Stem Cell  2017;21:399
  5. Translocation of the papillomavirus L2/vDNA complex across the limiting membrane requires the onset of mitosis.
    Authors: Calton Et al.
    PLoS Pathog  2017;13:e1006200
  6. Canonical Notch signaling plays an instructive role in auditory supporting cell development.
    Authors: Campbell Et al.
    Zoological Lett  2016;6:19484
  7. Generation of serotonin neurons from human pluripotent stem cells.
    Authors: Lu Et al.
    Nat Biotechnol  2016;34:89
  8. Notch3 drives development and progression of cholangiocarcinoma
    Authors: Guest Et al.
    Proc Natl Acad Sci U S A.  2016;113:12250
  9. Analysing human neural stem cell ontogeny by consecutive isolation of Notch active neural progenitors.
    Authors: Edri Et al.
    Nat Commun  2015;6:6500
  10. Generation of clinical-grade human induced pluripotent stem cells in Xeno-free conditions.
    Authors: Wang Et al.
    Stem Cell Res Ther  2015;6:223
  11. On the origin of vertebrate somites.
    Authors: Onai Et al.
    Blood  2015;1:33
  12. A small molecule targeting ALK1 prevents Notch cooperativity and inhibits functional angiogenesis.
    Authors: Kerr Et al.
    Angiogenesis  2015;18:209
  13. Neurogenin 3 Expressing Cells in the Human Exocrine Pancreas Have the Capacity for Endocrine Cell Fate.
    Authors: Gomez Et al.
    Sci Rep  2015;10:e0133862
  14. Pleiotropic effects of Sox2 during the development of the zebrafish epithalamus.
    Authors: Pavlou Et al.
    PLoS One  2014;9:e87546
  15. Astrocyte-derived endothelin-1 inhibits remyelination through notch activation.
    Authors: Hammond Et al.
    Neuron  2014;81:588
  16. Canonical Notch signalling is inactive in urothelial carcinoma.
    Authors: Greife Et al.
    BMC Cancer  2014;14:628
  17. Mir-23a and mir-125b regulate neural stem/progenitor cell proliferation by targeting Musashi1.
    Authors: Gioia Et al.
    Anticancer Res  2014;11:1105
  18. Generating regionalized neuronal cells from pluripotency, a step-by-step protocol.
    Authors: Kirkeby Et al.
    Front Cell Neurosci  2013;6:64
  19. Common developmental pathways link tooth shape to regeneration.
    Authors: Fraser Et al.
    Dev Biol  2013;377:399
  20. The role of Notch and γ-secretase inhibition in an ovarian cancer model.
    Authors: Shah Et al.
    J Neurosci  2013;33:801
  21. Presenilin1 regulates histamine neuron development and behavior in zebrafish, danio rerio.
    Authors: Sundvik Et al.
    J Neurosci  2013;33:1589
  22. Notch increases the shedding of HB-EGF by ADAM12 to potentiate invadopodia formation in hypoxia.
    Authors: Díaz Et al.
    J Cell Biol  2013;201:279
  23. Inflammation-mediated notch signaling skews fanconi anemia hematopoietic stem cell differentiation.
    Authors: Du Et al.
    J Immunol  2013;191:2806
  24. Shaping organs by a wingless-int/Notch/nonmuscle myosin module which orients feather bud elongation.
    Authors: Li Et al.
    Proc Natl Acad Sci U S A  2013;110:E1452
  25. Opposing effects of bacitracin on human papillomavirus type 16 infection: enhancement of binding and entry and inhibition of endosomal penetration.
    Authors: Campos Et al.
    J Virol  2012;86:4169
  26. Notch signaling inhibits axon regeneration.
    Authors: Bejjani and Hammarlund
    PLoS One  2012;73:268
  27. Fibulin-3 promotes glioma growth and resistance through a novel paracrine regulation of Notch signaling.
    Authors: Hu Et al.
    Cancer Res  2012;72:3873
  28. Jagged1 and Notch1 help edit M cell patterning in Peyer's patch follicle epithelium.
    Authors: Hsieh and Lo
    Dev Comp Immunol  2012;37:306
  29. Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease.
    Authors: Boulter Et al.
    Nat Med  2012;18:572
  30. Notch and TGFβ form a reciprocal positive regulatory loop that suppresses murine prostate basal stem/progenitor cell activity.
    Authors: Valdez Et al.
    RNA Biol  2012;11:676
  31. Notch promotes vascular maturation by inducing integrin-mediated smooth muscle cell adhesion to the endothelial basement membrane.
    Authors: Scheppke Et al.
    Cell Stem Cell  2012;119:2149
  32. Characterization of full-length and proteolytic cleavage fragments of desmoglein-2 in native human colon and colonic epithelial cell lines.
    Authors: Kolegraff Et al.
    Cell Adh Migr  2011;5:306
  33. Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signaling.
    Authors: Berndt Et al.
    J Cell Biol  2011;194:737
  34. Group II metabotropic glutamate receptor stimulation triggers production and release of Alzheimer's amyloid(β)42 from isolated intact nerve terminals.
    Authors: Kim Et al.
    Neuron  2010;30:3870
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