Catalog Number: 2654
Alternate Names: CW
Chemical Name: 3,5-Bis(4-nitrophenoxy)benzoic acid
Biological Activity
Inhibitor of γ-secretase; causes a decrease in the released levels of Aβ42 and notch-1 Aβ-like peptide 25 (Nβ25).
Technical Data
  • M.Wt:
    396.31
  • Formula:
    C19H12N2O8
  • Solubility:
    Soluble to 50 mM in 1.1eq. NaOH and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    173550-33-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Secretion of the notch-1 Aβ-like peptide during notch signaling.
    Okochi et al.
    J.Biol.Chem., 2006;281:7890
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Compound W include:

1 Citations: Showing 1 - 1

  1. Canonical Notch signalling is inactive in urothelial carcinoma.
    Authors: Greife Et al.
    BMC Cancer 2014;14:628

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