Discontinued Product

2841 has been discontinued.
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Curcumin | CAS No. 458-37-7 | Apoptosis Inducer Compounds
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Description: Antitumor, anti-inflammatory and antioxidant
Alternative Names: Diferuloylmethane

Chemical Name: (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione

Product Details
Citations (5)
Reviews (1)

Biological Activity

Curcumin is an antitumor, anti-inflammatory and antioxidant agent. Downregulates expression of reactive-oxygen-generating enzymes (cyclooxygenase, lipoxygenase, iNOS), TNFα, IL-1, IL-6, PKC, EGFR, NF-κB, IκB kinase and more. Upregulates expression of PPARγ, p53, Nrf2. Also displays antimicrobial, antidiabetic neuro- and cardioprotective properties in vivo.

Technical Data

Soluble to 10 mM in DMSO and to 5 mM in ethanol
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Antitumour, anti-invasion, and antimetastatic effects of curcumin.
    Kuttan et al.
    Adv.Exp.Med.Biol., 2007;595:173
  2. Neuroprotective effects of curcumin.
    Cole et al.
    Adv.Exp.Med.Biol., 2007;595:197
  3. Molecular targets of curcumin.
    Adv.Exp.Med.Biol., 2007;595:227
  4. Cardioprotective effects of curcumin.
    Miriyala et al.
    Adv.Exp.Med.Biol., 2007;595:359
  5. Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets.
    Aggarwal and Sung
    TiPS, 2009;30:85

Product Datasheets

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Citations for Curcumin

The citations listed below are publications that use Tocris products. Selected citations for Curcumin include:

5 Citations: Showing 1 - 5


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Reviews for Curcumin

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Curcumin treatment of mouse macrophages
By Anonymous on 09/24/2019
Application: Species: Mouse

used at 10um to activate anti-oxidant response in mouse macrophages

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