Catalog Number: 2841
Alternate Names: Diferuloylmethane
Chemical Name: (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione
Biological Activity
Antitumor, anti-inflammatory and antioxidant agent. Downregulates expression of reactive-oxygen-generating enzymes (cyclooxygenase, lipoxygenase, iNOS), TNFα, IL-1, IL-6, PKC, EGFR, NF-κB, IκB kinase and more. Upregulates expression of PPARγ, p53, Nrf2. Also displays antimicrobial, antidiabetic neuro- and cardioprotective properties in vivo.
Technical Data
  • M.Wt:
    368.38
  • Formula:
    C21H20O6
  • Solubility:
    Soluble to 10 mM in DMSO and to 5 mM in ethanol
  • Storage:
    Store at -20°C
  • CAS No:
    458-37-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Antitumour, anti-invasion, and antimetastatic effects of curcumin.
    Kuttan et al.
    Adv.Exp.Med.Biol., 2007;595:173
  2. Neuroprotective effects of curcumin.
    Cole et al.
    Adv.Exp.Med.Biol., 2007;595:197
  3. Molecular targets of curcumin.
    Lin
    Adv.Exp.Med.Biol., 2007;595:227
  4. Cardioprotective effects of curcumin.
    Miriyala et al.
    Adv.Exp.Med.Biol., 2007;595:359
  5. Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets.
    Aggarwal and Sung
    TiPS, 2009;30:85
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Curcumin include:

1 Citations: Showing 1 - 1

  1. Rescue of an in vitro neuron phenotype identified in Niemann-Pick disease, type C1 induced pluripotent stem cell-derived neurons by modulating the WNT pathway and calcium signaling.
    Authors: Efthymiou Et al.
    J Neurosci 2015;4:230

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