Chemical Name: (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione
Biological ActivityCurcumin is an antitumor, anti-inflammatory and antioxidant agent. Downregulates expression of reactive-oxygen-generating enzymes (cyclooxygenase, lipoxygenase, iNOS), TNFα, IL-1, IL-6, PKC, EGFR, NF-κB, IκB kinase and more. Upregulates expression of PPARγ, p53, Nrf2. Also displays antimicrobial, antidiabetic neuro- and cardioprotective properties in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Antitumour, anti-invasion, and antimetastatic effects of curcumin.
Kuttan et al.
Neuroprotective effects of curcumin.
Cole et al.
Molecular targets of curcumin.
Cardioprotective effects of curcumin.
Miriyala et al.
Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets.
Aggarwal and Sung
Citations for Curcumin
The citations listed below are publications that use Tocris products. Selected citations for Curcumin include:
5 Citations: Showing 1 - 5
CBP Regulates Recruitment and Release of Promoter-Proximal RNA Polymerase II.
Authors: Boija Et al.
Mol Cell 2017;68:491
Protection against β-amyloid-induced synaptic and memory impairments via altering β-amyloid assembly by bis(heptyl)-cognitin.
Authors: Chang Et al.
Sci Rep 2015;5:10256
Rescue of an in vitro neuron phenotype identified in Niemann-Pick disease, type C1 induced pluripotent stem cell-derived neurons by modulating the WNT pathway and calcium signaling.
Authors: Efthymiou Et al.
J Neurosci 2015;4:230
Curcumin inhibits HCV replication by induction of heme oxygenase-1 and suppression of AKT.
Authors: Chen Et al.
Int J Mol Med 2012;30:1021
Analgesic effects of intrathecal curcumin in the rat formalin test.
Authors: Han Et al.
Korean J Pain 2012;25:43252
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used at 10um to activate anti-oxidant response in mouse macrophages