Catalog Number: 0970
Chemical Name: 4-[2-(3,5-Dimethyl-2-oxo-cyclohexyl)-2-hydroxyethyl]-2,6-piperidinedione
Biological Activity
Selective inhibitor of eukaryotic (over prokaryotic) protein synthesis, blocking tRNA binding and release from ribosomes. Induces apoptosis in a variety of transformed and normal cell lines, including T cells. Competitively inhibits the PPIase hFKBP12 (Ki = 3.4 μM). Antifungal antibiotic.
Technical Data
  • M.Wt:
    281.35
  • Formula:
    C15H23NO4
  • Solubility:
    Soluble to 50 mM in ethanol and to 25 mM in water
  • Purity:
    >97%
  • Storage:
    Desiccate at RT
  • CAS No:
    66-81-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Synthesis and cytotoxic evaluation of cycloheximide derivatives as potential inhibitors of FKBP12 with neuroregenerative properties.
    Christner et al.
    J.Med.Chem., 1999;42:3615
  2. The mechanism by which cycloheximide and related glutarimide antibiotics inhibit peptide synthesis on reticulocyte ribosomes.
    Obrig et al.
    J.Biol.Chem., 1971;246:174
  3. Cycloheximide-induced T-cell death is mediated by a Fas-associated death domain-dependent mechanism.
    Tang et al.
    J.Biol.Chem., 1999;274:7245
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Cycloheximide include:

10 Citations: Showing 1 - 10
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  1. Acute Stress Suppresses Synaptic Inhibition and Increases Anxiety via Endocannabinoid Release in the Basolateral Amygdala.
    Authors: Di Et al.
    J.Neurosci. 2016;36:8461
  2. A balance of positive and negative regulators determines the pace of the segmentation clock.
    Authors: Wiedermann Et al.
    Elife 2015;4
  3. Activity-dependent rapid local RhoA synthesis is required for hippocampal synaptic plasticity.
    Authors: Briz Et al.
    Neurobiol Dis 2015;35:2269
  4. A molecular brake controls the magnitude of long-term potentiation.
    Authors: Wang Et al.
    Nat Commun 2014;5:3051
  5. Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion.
    Authors: Bhatnagar Et al.
    J Biol Chem 2014;289:25276
  6. Phosphorylation of FMRP and alterations of FMRP complex underlie enhanced mLTD in adult rats triggered by early life seizures.
    Authors: Bernard Et al.
    J Appl Physiol (1985) 2013;59:42736
  7. Oxytocin-stimulated NFAT transcriptional activation in human myometrial cells.
    Authors: Pont Et al.
    Mol.Endocrinol. 2012;26:1743
  8. The effect of denervation on protein synthesis and degradation in adult rat diaphragm muscle.
    Authors: Argadine Et al.
    J Neurosci 2009;107:438
  9. Cyclooxygenase-2-derived prostaglandin F2alpha mediates endothelium-dependent contractions in the aortae of hamsters with increased impact during aging.
    Authors: Wong Et al.
    Circ Res 2009;104:228
  10. Heat shock protein 60 or 70 activates nitric-oxide synthase (NOS) I- and inhibits NOS II-associated signaling and depresses the mitochondrial apoptotic cascade during brain stem death.
    Authors: Chan Et al.
    J Neurosci 2007;282:4585

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