Chemical Name: 4-[2-(3,5-Dimethyl-2-oxo-cyclohexyl)-2-hydroxyethyl]-2,6-piperidinedione
Biological ActivityCycloheximide is a selective inhibitor of eukaryotic (over prokaryotic) protein synthesis, blocking tRNA binding and release from ribosomes. Induces apoptosis in a variety of transformed and normal cell lines, including T cells. Competitively inhibits the PPIase hFKBP12 (Ki = 3.4 μM). Also inhibits ferroptosis. Antifungal antibiotic. Exhibits anti-MERS-CoV activity in Vero cells in vitro (IC50 = 0.16 μM).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Synthesis and cytotoxic evaluation of cycloheximide derivatives as potential inhibitors of FKBP12 with neuroregenerative properties.
Christner et al.
The mechanism by which cycloheximide and related glutarimide antibiotics inhibit peptide synthesis on reticulocyte ribosomes.
Obrig et al.
Cycloheximide-induced T-cell death is mediated by a Fas-associated death domain-dependent mechanism.
Tang et al.
Ferroptosis: process and function.
Xie et al.
Coronavirus minus-strand RNA synthesis and effect of cycloheximide on coronavirus RNA synthesis.
Sawicki and Sawicki et al.
Citations for Cycloheximide
The citations listed below are publications that use Tocris products. Selected citations for Cycloheximide include:
18 Citations: Showing 1 - 10
AMPK activation regulates P-body dynamics in mouse sensory neurons in vitro and in vivo.
Authors: Paige Et al.
Neurobiol Pain 2019;5
Staufen1 links RNA stress granules and autophagy in a model of neurodegeneration.
Authors: Paul Et al.
Nat Commun 2018;9:3648
Rhomboid domain-containing protein 1 promotes breast cancer progression by regulating the p-Akt and CDK2 levels.
Authors: Zhang Et al.
Cell Commun Signal 2018;16:65
Nongenomic Glucocorticoid Suppression of a Postsynaptic Potassium Current via Emergent Autocrine Endocannabinoid Signaling in Hypothalamic Neuroendocrine Cells following Chronic Dehydration.
Authors: Wu and Tasker
Acute Stress Suppresses Synaptic Inhibition and Increases Anxiety via Endocannabinoid Release in the Basolateral Amygdala.
Authors: Di Et al.
A balance of positive and negative regulators determines the pace of the segmentation clock.
Authors: Wiedermann Et al.
Activity-dependent rapid local RhoA synthesis is required for hippocampal synaptic plasticity.
Authors: Briz Et al.
Neurobiol Dis 2015;35:2269
A molecular brake controls the magnitude of long-term potentiation.
Authors: Wang Et al.
Nat Commun 2014;5:3051
Phosphorylation and degradation of tomosyn-2 de-represses Ins secretion.
Authors: Bhatnagar Et al.
J Biol Chem 2014;289:25276
Opioid receptor function is regulated by post-endocytic peptide processing.
Authors: Gupta Et al.
J Biol Chem 2014;289:19613
Long lasting protein synthesis- and activity-dependent spine shrinkage and elimination after synaptic depression.
PLoS One 2013;8:e71155
Phosphorylation of FMRP and alterations of FMRP complex underlie enhanced mLTD in adult rats triggered by early life seizures.
Authors: Bernard Et al.
J Appl Physiol (1985) 2013;59:42736
Oxytocin-stimulated NFAT transcriptional activation in human myometrial cells.
Authors: Pont Et al.
Dual regulation of fragile X mental retardation protein by group I metabotropic glutamate receptors controls translation-dependent epileptogenesis in the hippocampus.
Authors: Zhao Et al.
J Neurosci 2011;31:725
Pharmacological and genetic accumulation of hypoxia-inducible factor-1alpha enhances excitatory synaptic transmission in hippocampal neurons through the production of vascular endothelial growth factor.
Authors: Huang Et al.
J Neurosci 2010;30:6080
The effect of denervation on protein synthesis and degradation in adult rat diaphragm muscle.
Authors: Argadine Et al.
J Neurosci 2009;107:438
Cyclooxygenase-2-derived prostaglandin F2alpha mediates endothelium-dependent contractions in the aortae of hamsters with increased impact during aging.
Authors: Wong Et al.
Circ Res 2009;104:228
Heat shock protein 60 or 70 activates nitric-oxide synthase (NOS) I- and inhibits NOS II-associated signaling and depresses the mitochondrial apoptotic cascade during brain stem death.
Authors: Chan Et al.
J Neurosci 2007;282:4585
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