Cycloheximide

  ( 13 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:0970
Chemical Name:4-[2-(3,5-Dimethyl-2-oxo-cyclohexyl)-2-hydroxyethyl]-2,6-piperidinedione
Product Details
Citations (13)
Reviews
Biological Activity
Selective inhibitor of eukaryotic (over prokaryotic) protein synthesis, blocking tRNA binding and release from ribosomes. Induces apoptosis in a variety of transformed and normal cell lines, including T cells. Competitively inhibits the PPIase hFKBP12 (Ki = 3.4 μM). Antifungal antibiotic.
Technical Data
  • M.Wt:
    281.35
  • Formula:
    C15H23NO4
  • Solubility:
    Soluble to 50 mM in ethanol and to 25 mM in water
  • Purity:
    >97
  • Storage:
    Desiccate at RT
  • CAS No:
    66-81-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Cycloheximide include:

13 Citations: Showing 1 - 10
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  1. Acute Stress Suppresses Synaptic Inhibition and Increases Anxiety via Endocannabinoid Release in the Basolateral Amygdala.
    Authors: Di Et al.
    J.Neurosci.  2016;36:8461
  2. A balance of positive and negative regulators determines the pace of the segmentation clock.
    Authors: Wiedermann Et al.
    Elife  2015;4
  3. Activity-dependent rapid local RhoA synthesis is required for hippocampal synaptic plasticity.
    Authors: Briz Et al.
    Neurobiol Dis  2015;35:2269
  4. A molecular brake controls the magnitude of long-term potentiation.
    Authors: Wang Et al.
    Nat Commun  2014;5:3051
  5. Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion.
    Authors: Bhatnagar Et al.
    J Biol Chem  2014;289:25276
  6. Opioid receptor function is regulated by post-endocytic peptide processing.
    Authors: Gupta Et al.
    J Biol Chem  2014;289:19613
  7. Phosphorylation of FMRP and alterations of FMRP complex underlie enhanced mLTD in adult rats triggered by early life seizures.
    Authors: Bernard Et al.
    J Appl Physiol (1985)  2013;59:42736
  8. Oxytocin-stimulated NFAT transcriptional activation in human myometrial cells.
    Authors: Pont Et al.
    Mol.Endocrinol.  2012;26:1743
  9. Dual regulation of fragile X mental retardation protein by group I metabotropic glutamate receptors controls translation-dependent epileptogenesis in the hippocampus.
    Authors: Zhao Et al.
    J Neurosci  2011;31:725
  10. Pharmacological and genetic accumulation of hypoxia-inducible factor-1alpha enhances excitatory synaptic transmission in hippocampal neurons through the production of vascular endothelial growth factor.
    Authors: Huang Et al.
    J Neurosci  2010;30:6080
  11. The effect of denervation on protein synthesis and degradation in adult rat diaphragm muscle.
    Authors: Argadine Et al.
    J Neurosci  2009;107:438
  12. Cyclooxygenase-2-derived prostaglandin F2alpha mediates endothelium-dependent contractions in the aortae of hamsters with increased impact during aging.
    Authors: Wong Et al.
    Circ Res  2009;104:228
  13. Heat shock protein 60 or 70 activates nitric-oxide synthase (NOS) I- and inhibits NOS II-associated signaling and depresses the mitochondrial apoptotic cascade during brain stem death.
    Authors: Chan Et al.
    J Neurosci  2007;282:4585
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Average Rating: 5 (Based on 2 reviews)

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  Excellent
  Mouse Paramananda Saikia 01/11/2018
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Species Mouse

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Other Experimental Details required dilution made fresh.
  Excellent
  Human Winnie Hui 01/04/2018
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Species Human

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