Selective inhibitor of eukaryotic (over prokaryotic) protein synthesis, blocking tRNA binding and release from ribosomes. Induces apoptosis in a variety of transformed and normal cell lines, including T cells. Competitively inhibits the PPIase hFKBP12 (Ki
= 3.4 μ
M). Antifungal antibiotic.
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Synthesis and cytotoxic evaluation of cycloheximide derivatives as potential inhibitors of FKBP12 with neuroregenerative properties.
Christner et al.
The mechanism by which cycloheximide and related glutarimide antibiotics inhibit peptide synthesis on reticulocyte ribosomes.
Obrig et al.
Cycloheximide-induced T-cell death is mediated by a Fas-associated death domain-dependent mechanism.
Tang et al.
The citations listed below are publications that use Tocris products. Selected citations for Cycloheximide include:
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