Cytochalasin D

  ( 16 citations )    
Product Datasheet
Catalog Number:1233
Alternate Names:Zygosporin A
Chemical Name:(7S,13E,16S,18R,19E,21R)-21-(Acetyloxy)- 7,18-dihydroxy-16,18-dimethyl-10-phenyl[11]cytochalasa-6(12),13,19-triene-1,17-dione
Product Details
Citations (16)
Biological Activity
Potent disruptor of actin filament function. Alters tight junction permeability. Unlike cytochalasin B (Cat. No. 5474), does not inhibit monosaccharide transport across the plasma membrane.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 10 mM in ethanol with gentle warming and to 50 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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The citations listed below are publications that use Tocris products. Selected citations for Cytochalasin D include:

16 Citations: Showing 1 - 10
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  1. The effect of maternal diabetes on the Wnt-PCP pathway during embryogenesis as reflected in the developing mouse eye.
    Authors: Lopez-Escobar Et al.
    Proc Natl Acad Sci U S A  2015;8:157
  2. ICAM-1 suppresses tumor metastasis by inhibiting macrophage M2 polarization through blockade of efferocytosis.
    Authors: Yang Et al.
    Am J Physiol Cell Physiol  2015;6:e1780
  3. G-actin provides substrate-specificity to eukaryotic initiation factor 2α holophosphatases.
    Authors: Chen Et al.
    Elife  2015;4
  4. Actin dynamics tune the integrated stress response by regulating eukaryotic initiation factor 2α dephosphorylation.
    Authors: Chambers Et al.
    Elife  2015;4
  5. Actin-Cytoskeleton- and Rock-Mediated INM Are Required for Photoreceptor Regeneration in the Adult Zebrafish Retina.
    Authors: Lahne Et al.
    J Neurosci  2015;35:15612
  6. Centrosomal nucleolin is required for microtubule network organization.
    Authors: Gaume Et al.
    Cell Cycle  2015;14:902
  7. Caffeine Modulates Vesicle Release and Recovery at Cerebellar Parallel Fibre Terminals, Independently of Calcium and Cyclic AMP Signalling.
    Authors: Dobson Et al.
    Elife  2015;10:e0125974
  8. Actinomyosin contraction, phosphorylation of VE-cadherin, and actin remodeling enable melanoma-induced endothelial cell-cell junction disassembly.
    Authors: Weidert Et al.
    PLoS One  2014;9:e108092
  9. Osmotic surveillance mediates rapid wound closure through nucleotide release.
    Authors: Gault Et al.
    J Cell Biol  2014;207:767
  10. Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage.
    Authors: Lee Et al.
    Cell Death Dis  2014;111:E5114
  11. Recombinant probes reveal dynamic localization of CaMKIIα within somata of cortical neurons.
    Authors: Mora Et al.
    J Neurosci  2013;33:14579
  12. Cyclic AMP-Rap1A signaling activates RhoA to induce α(2c)-adrenoceptor translocation to the cell surface of microvascular smooth muscle cells.
    Authors: Jeyaraj Et al.
    Integr Biol (Camb)  2012;303:C499
  13. Curcumin inhibits glutamate release from rat prefrontal nerve endings by affecting vesicle mobilization.
    Authors: Lin Et al.
    PLoS One  2012;13:9097
  14. Endogenous patterns of mechanical stress are required for branching morphogenesis.
    Authors: Gjorevski and Nelson
    Biochem Biophys Res Commun  2010;2:424
  15. Tissue geometry patterns epithelial-mesenchymal transition via intercellular mechanotransduction.
    Authors: Gomez Et al.
    Dis Model Mech  2010;110:44
  16. The actin cytoskeleton differentially regulates NG115-401L cell ryanodine receptor and inositol 1,4,5-trisphosphate receptor induced calcium signaling pathways.
    Authors: Bose and Thomas
    Int J Mol Sci  2009;379:594
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