Catalog Number: 1233
Alternate Names: Zygosporin A
Chemical Name: (7S,13E,16S,18R,19E,21R)-21-(Acetyloxy)- 7,18-dihydroxy-16,18-dimethyl-10-phenyl[11]cytochalasa-6(12),13,19-triene-1,17-dione
Biological Activity
Potent disruptor of actin filament function. Alters tight junction permeability. Unlike cytochalasin B (Cat. No. 5474), does not inhibit monosaccharide transport across the plasma membrane.
Technical Data
  • M.Wt:
    507.63
  • Formula:
    C30H37NO6
  • Solubility:
    Soluble to 10 mM in ethanol with gentle warming and to 50 mM in DMSO
  • Purity:
    >95%
  • Storage:
    Desiccate at -20°C
  • CAS No:
    22144-77-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Cytochalasin D stimulation of tyrosine phosphorylation and phosphotyrosine-associated kinase activity in vascular smooth muscle cells.
    Abedi and Zachary
    Biochem.Biophys.Res.Commun., 1998;245:646
  2. Interaction of cytochalasin D with actin filaments in the presence of ADP and ATP.
    Carlier et al.
    J.Biol.Chem., 1986;261:2041
  3. Concentration-dependent effects of cytochalasin D on tight junctions and actin filaments in MDCK epithelial cells.
    Stevenson and Begg
    J.Cell Sci., 1994;107:367
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Cytochalasin D include:

13 Citations: Showing 1 - 10
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  1. The effect of maternal diabetes on the Wnt-PCP pathway during embryogenesis as reflected in the developing mouse eye.
    Authors: Lopez-Escobar Et al.
    Proc Natl Acad Sci U S A 2015;8:157
  2. ICAM-1 suppresses tumor metastasis by inhibiting macrophage M2 polarization through blockade of efferocytosis.
    Authors: Yang Et al.
    Am J Physiol Cell Physiol 2015;6:e1780
  3. G-actin provides substrate-specificity to eukaryotic initiation factor 2α holophosphatases.
    Authors: Chen Et al.
    Elife 2015;4
  4. Actin dynamics tune the integrated stress response by regulating eukaryotic initiation factor 2α dephosphorylation.
    Authors: Chambers Et al.
    Elife 2015;4
  5. Caffeine Modulates Vesicle Release and Recovery at Cerebellar Parallel Fibre Terminals, Independently of Calcium and Cyclic AMP Signalling.
    Authors: Dobson Et al.
    Elife 2015;10:e0125974
  6. Osmotic surveillance mediates rapid wound closure through nucleotide release.
    Authors: Gault Et al.
    J Cell Biol 2014;207:767
  7. Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage.
    Authors: Lee Et al.
    Cell Death Dis 2014;111:E5114
  8. Recombinant probes reveal dynamic localization of CaMKIIα within somata of cortical neurons.
    Authors: Mora Et al.
    J Neurosci 2013;33:14579
  9. Cyclic AMP-Rap1A signaling activates RhoA to induce α(2c)-adrenoceptor translocation to the cell surface of microvascular smooth muscle cells.
    Authors: Jeyaraj Et al.
    Integr Biol (Camb) 2012;303:C499
  10. Curcumin inhibits glutamate release from rat prefrontal nerve endings by affecting vesicle mobilization.
    Authors: Lin Et al.
    PLoS One 2012;13:9097
  11. Endogenous patterns of mechanical stress are required for branching morphogenesis.
    Authors: Gjorevski and Nelson
    Biochem Biophys Res Commun 2010;2:424
  12. Tissue geometry patterns epithelial-mesenchymal transition via intercellular mechanotransduction.
    Authors: Gomez Et al.
    Dis Model Mech 2010;110:44
  13. The actin cytoskeleton differentially regulates NG115-401L cell ryanodine receptor and inositol 1,4,5-trisphosphate receptor induced calcium signaling pathways.
    Authors: Bose and Thomas
    Int J Mol Sci 2009;379:594
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