Q: We want to know whether has the cross-reactivity with mouse or not. Could you please let me know?

A: Our product NBP1-28883 has not yet been tested against mouse samples, so we do not know for certain if this antibody will recognize the mouse protein. I have run an alignment of the immunogen range against the mouse protein. The immunogen has a 96% homology to the mouse protein, so it looks promising for testing in mouse samples. Since this species is not covered by our guarantee, your customer can use our Innovator's Reward.

DDR2 Antibody (3B11E4)

Novus Biologicals | Catalog # NBP1-28883

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Product Documents

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Product Specifications
Scientific Data
Applications
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot, ELISA, Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG_2A Clone # 3B11E4

View all DDR2 Primary Antibodies »

Product Specifications

Immunogen

Purified recombinant fragment of human DDR2 expressed in E. Coli.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG_2A

Scientific Data Images for DDR2 Antibody (3B11E4)

Western Blot: DDR2 Antibody (3B11E4)BSA Free [NBP1-28883]

Western Blot: DDR2 Antibody (3B11E4) [NBP1-28883] - Analysis using DDR2 mouse mAb against truncated DDR2 recombinant protein.

Immunocytochemistry/ Immunofluorescence: DDR2 Antibody (3B11E4) - BSA Free [NBP1-28883]

Immunocytochemistry/Immunofluorescence: DDR2 Antibody (3B11E4) [NBP1-28883] - Analysis of A549 cells using DDR2 mouse mAb (green). Red: Actin filaments have been labeled with DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye.

Immunohistochemistry-Paraffin: DDR2 Antibody (3B11E4) - BSA Free [NBP1-28883]

Immunohistochemistry-Paraffin: DDR2 Antibody (3B11E4) [NBP1-28883] - Analysis of human skeletal musle tissues using DDR2 mouse mAb.

Applications for DDR2 Antibody (3B11E4)

Application

Recommended Usage

ELISA

1:10000

Immunocytochemistry/ Immunofluorescence

1:200 - 1:1000

Immunohistochemistry

1:10 - 1:500

Immunohistochemistry-Paraffin

1:200 - 1:1000

Western Blot

1:500 - 1:2000

Formulation, Preparation, and Storage

Purification

Ascites

Formulation

Ascites

Preservative

0.03% Sodium Azide

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: DDR2

DDR2 (discoidin domain receptor family, member 2) is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/ threonine (STK) kinase catalytic domains. Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein.

Long Name

Discoidin Domain Receptor 2

Alternate Names

TKT, Trk3, Tyro-10

Entrez Gene IDs

4921 (Human)

Gene Symbol

DDR2

UniProt

Q16832

Additional DDR2 Products

Product Documents for DDR2 Antibody (3B11E4)

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Certificate of Analysis

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Product Specific Notices for DDR2 Antibody (3B11E4)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

Receptor Tyrosine Kinases (RTKs)

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