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Difopein

Catalog #: 2145 Datasheet / COA / SDS

Discontinued Product

2145 has been discontinued.
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Difopein
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Description: High affinity inhibitor of 14.3.3 proteins; induces apoptosis
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Biological Activity

Dimeric version of R18 peptide (Cat. No. 2144) that binds to 14.3.3 proteins with high affinity. Competitively inhibits 14.3.3-ligand interactions; blocks the ability of 14.3.3 to bind to target proteins such as Raf-1, Bad, ASK1 and exoenzyme S. Induces apoptosis when expressed in COS-7 and various cancer cells.

Technical Data

M.Wt:
6387.17
Formula:
C273H424N76O89S6
Sequence:
SADGAPHCVPRDLSWLDLEANMCLPGAAGLDSADGAPHCVPRDLSWLDLEANMCLPGAAGLE
Solubility:
Soluble to 5 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
396834-58-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. 14.3.3 proteins mediate an essential anti-apoptotic signal.
    Masters and Fu
    J.Biol.Chem., 2001;276:45193
  2. Survival-promoting functions of 14.3.3 proteins.
    Masters et al.
    Biochem.Soc.Transactions, 2002;30:360
  3. The 14.3.3 cancer connection.
    Hermeking
    Nature Rev.Cancer, 2003;3:931

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