Difopein (CAS 396834-58-5): R&D Systems
Catalog Number: 2145
Biological Activity
Dimeric version of R18 peptide (Cat. No. 2144) that binds to 14.3.3 proteins with high affinity. Competitively inhibits 14.3.3-ligand interactions; blocks the ability of 14.3.3 to bind to target proteins such as Raf-1, Bad, ASK1 and exoenzyme S. Induces apoptosis when expressed in COS-7 and various cancer cells.
Technical Data
  • M.Wt:
    6387.17
  • Formula:
    C273H424N76O89S6
  • Sequence:
    SADGAPHCVPRDLSWLDLEANMCLPGAAGLDSADGAPHCVPRDLSWLDLEANMCLPGAAGLE
  • Solubility:
    Soluble to 5 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    396834-58-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. 14.3.3 proteins mediate an essential anti-apoptotic signal.
    Masters and Fu
    J.Biol.Chem., 2001;276:45193
  2. Survival-promoting functions of 14.3.3 proteins.
    Masters et al.
    Biochem.Soc.Transactions, 2002;30:360

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