Chemical Name: (2S,13bS)-2-Methoxy-2,3,5,6,8,9,10,13-octahydro-1H,12H-benzo[i]pyrano[3,4-g]indolizin-12-one hydrobromide
Biological ActivityDihydro-β-erythroidine hydrobromide is a member of the Erythrina alkaloids, it is a competitive nicotinic acetylcholine receptor antagonist with moderate selectivity for the neuronal α4 receptor subunit (IC50 values are 0.19 and 0.37 μM for α4β4 and α4β2 receptors, respectively). Antagonizes behavioral effects of nicotine in vivo. Dihydro-β-erythroidine blocks excitation of striatal GABAergic neurons, which completely suppress polysynaptic inhibition between striatal cholinergic interneurons. Dihydro-β-erythroidine hydrobromide has antidepressive-like effects in mice (forced swim and mouse suspension). Orally bioavailable.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Binding of the nicotinic cholinergic antagonist, dihydro-β-erythroidine, to rat brain tissue.
Williams and Robinson
In vivo pharmacological effects of dihydro-β-erythroidine, a nicotinic antagonist, in mice.
Damaj et al.
Multiple determinants of dihydro-β-erythroidine sensitivity on rat neuronal nicotinic receptor α subunits.
Harvey et al.
Citations for Dihydro-β-erythroidine hydrobromide
The citations listed below are publications that use Tocris products. Selected citations for Dihydro-β-erythroidine hydrobromide include:
30 Citations: Showing 1 - 10
GABAergic inhibition in dual-transmission cholinergic and GABAergic striatal interneurons is abolished in Parkinson disease.
Authors: Lozovaya Et al.
Nat Commun 2349;9(1):1422
Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner.
Authors: Dorst Et al.
Nat Commun 2020;11:5113
Neural mechanisms of contextual modulation in the retinal direction selective circuit.
Authors: Huang Et al.
Nat Commun 2019;10:2431
Pauses in Cholinergic Interneuron Activity Are Driven by Excitatory Input and Delayed Rectification, with DA Modulation.
Authors: Zhang Et al.
Differential effects of α4β2 nicotinic receptor antagonists and partial-agonists on contextual fear extinction in male C57BL/6 mice.
Authors: Kutlu Et al.
Psychopharmacology (Berl) 2018;235:1211
Local GABAA receptor mediated suppression of DA release within the nucleus accumbens.
Authors: Brodnik Et al.
ACS Chem Neurosci 2018;17:1978
Inhibition of peripheral macrophages by nicotinic acetylcholine receptor agonists suppresses spinal microglial activation and neuropathic pain in mice with peripheral nerve injury.
J Neuroinflammation 2018;15(1):96
Differential processing of thalamic information via distinct striatal interneuron circuits.
Nat Commun 2017;8:15860
Selective and regulated trapping of nicotinic receptor weak base ligands and relevance to smoking cessation.
Authors: Govind Et al.
Speed and segmentation control mechanisms characterized in rhythmically-active circuits created from spinal neurons produced from genetically-tagged embryonic stem cells.
Authors: Sternfeld Et al.
Plasticity in Brainstem Mechanisms of Pain Modulation by Nicotinic Acetylcholine Receptors in the Rat.
Authors: Jareczek Et al.
Spontaneous Release Regulates Synaptic Scaling in the Embryonic Spinal Network In Vivo
Authors: Miguel Angel Garcia-Bereguiain Et al.
The Journal of Neuroscience 2016;6:7268
Nicotinic and opioid receptor regulation of striatal DA D2-receptor mediated transmission
Authors: Mamaligas Et al.
Scientific Reports 2016;6:37834
A cholinergic basal forebrain feeding circuit modulates appetite suppression
Authors: Herman Et al.
Nicotine evokes kinetic tremor by activating the inferior olive via α7 nicotinic acetylcholine receptors.
Authors: Kunisawa Et al.
Behav.Brain Res. 2016;314:173
Acetylcholine induces GABA release onto rod bipolar cells through heteromeric nicotinic receptors expressed in A17 amacrine cells.
Authors: Elgueta Et al.
PLoS One 2015;9:6
Ins enhances striatal DA release by activating cholinergic interneurons and thereby signals reward.
Authors: Stouffer Et al.
Nat Commun 2015;6:8543
Corelease of acetylcholine and GABA from cholinergic forebrain neurons.
Authors: Saunders Et al.
J Neurosci 2015;4
Novel aspects of cholinergic regulation of colonic ion transport.
Authors: Bader and Diener
An Asymmetric Increase in Inhibitory Synapse Number Underlies the Development of a Direction Selective Circuit in the Retina.
Authors: Morrie and Feller
Functional Upregulation of α4* Nicotinic Acetylcholine Receptors in VTA GABAergic Neurons Increases Sensitivity to Nicotine Reward.
Authors: Ngolab Et al.
J Neurosci 2015;35:8570
Absence of plateau potentials in dLGN cells leads to a breakdown in retinogeniculate refinement.
Authors: Dilger Et al.
J Neurosci 2015;35:3652
Greater ethanol inhibition of presynaptic DA release in C57BL/6J than DBA/2J mice: Role of nicotinic acetylcholine receptors.
Authors: Yorgason Et al.
Front Cell Neurosci 2015;284:854
Nicotinic acetylcholine receptors containing the α7-like subunit mediate contractions of muscles responsible for space positioning of the snail, Helix pomatia L. tentacle.
Authors: Kiss Et al.
PLoS One 2014;9:e109538
Nicotine elicits prolonged calcium signaling along ventral hippocampal axons.
Authors: Zhong Et al.
Pharmacol Res Perspect 2013;8:e82719
Striatal DA transmission is subtly modified in human A53Tα-synuclein overexpressing mice.
Authors: Platt Et al.
PLoS One 2012;7:e36397
Gamma oscillations are generated locally in an attention-related midbrain network.
Authors: Goddard Et al.
Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses.
Authors: Caiati Et al.
Sci Rep 2012;2:285
Cytisine induces autonomic cardiovascular responses via activations of different nicotinic receptors.
Authors: Li Et al.
Auton Neurosci 2010;154:14
Specific subtypes of nicotinic cholinergic receptors involved in sympathetic and parasympathetic cardiovascular responses.
Authors: Li Et al.
Neurosci Lett 2009;462:20
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
VersaClone cDNA Plasmids
Reviews for Dihydro-β-erythroidine hydrobromide
There are currently no reviews for this product. Be the first to review Dihydro-β-erythroidine hydrobromide and earn rewards!
Have you used Dihydro-β-erythroidine hydrobromide?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image