Dihydro-β-erythroidine hydrobromide

  ( 21 citations )    
Product Datasheet
Catalog Number:2349
Alternate Names:DHβE
Chemical Name:(2S,13bS)-2-Methoxy-2,3,5,6,8,9,10,13-octahydro-1H,12H-benzo[i]pyrano[3,4-g]indolizin-12-one hydrobromide
Product Details
Citations (21)
Supplemental Products
Reviews
Biological Activity
Competitive nicotinic acetylcholine receptor antagonist with moderate selectivity for the neuronal α4 receptor subunit (IC50 values are 0.19 and 0.37 μM for α4β4 and α4β2 receptors respectively). Antagonizes behavioral effects of nicotine in vivo.
Technical Data
  • M.Wt:
    356.26
  • Formula:
    C16H21NO3.HBr
  • Solubility:
    Soluble to 100 mM in water and to 25 mM in DMSO
  • Purity:
    >98
  • Storage:
    Desiccate at RT
  • CAS No:
    29734-68-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Dihydro-β-erythroidine hydrobromide include:

21 Citations: Showing 1 - 10
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  1. Inhibition of peripheral macrophages by nicotinic acetylcholine receptor agonists suppresses spinal microglial activation and neuropathic pain in mice with peripheral nerve injury.
    Authors: Kiguchi
    J Neuroinflammation  2018;15(1):96
  2. Differential processing of thalamic information via distinct striatal interneuron circuits.
    Authors: Assous
    Nat Commun  2017;8:15860
  3. Spontaneous Release Regulates Synaptic Scaling in the Embryonic Spinal Network In Vivo
    Authors: Miguel Angel Garcia-Bereguiain Et al.
    The Journal of Neuroscience  2016;6:7268
  4. Nicotinic and opioid receptor regulation of striatal dopamine D2-receptor mediated transmission
    Authors: Mamaligas Et al.
    Scientific Reports  2016;6:37834
  5. A cholinergic basal forebrain feeding circuit modulates appetite suppression
    Authors: Herman Et al.
    Nature  2016;538:253
  6. Nicotine evokes kinetic tremor by activating the inferior olive via α7 nicotinic acetylcholine receptors.
    Authors: Kunisawa Et al.
    Behav.Brain Res.  2016;314:173
  7. Acetylcholine induces GABA release onto rod bipolar cells through heteromeric nicotinic receptors expressed in A17 amacrine cells.
    Authors: Elgueta Et al.
    PLoS One  2015;9:6
  8. Insulin enhances striatal dopamine release by activating cholinergic interneurons and thereby signals reward.
    Authors: Stouffer Et al.
    Nat Commun  2015;6:8543
  9. Corelease of acetylcholine and GABA from cholinergic forebrain neurons.
    Authors: Saunders Et al.
    J Neurosci  2015;4
  10. Novel aspects of cholinergic regulation of colonic ion transport.
    Authors: Bader and Diener
    Elife  2015;3:e00139
  11. An Asymmetric Increase in Inhibitory Synapse Number Underlies the Development of a Direction Selective Circuit in the Retina.
    Authors: Morrie and Feller
    Neuroscience  2015;35:9281
  12. Functional Upregulation of α4* Nicotinic Acetylcholine Receptors in VTA GABAergic Neurons Increases Sensitivity to Nicotine Reward.
    Authors: Ngolab Et al.
    J Neurosci  2015;35:8570
  13. Absence of plateau potentials in dLGN cells leads to a breakdown in retinogeniculate refinement.
    Authors: Dilger Et al.
    J Neurosci  2015;35:3652
  14. Greater ethanol inhibition of presynaptic dopamine release in C57BL/6J than DBA/2J mice: Role of nicotinic acetylcholine receptors.
    Authors: Yorgason Et al.
    Front Cell Neurosci  2015;284:854
  15. Nicotinic acetylcholine receptors containing the α7-like subunit mediate contractions of muscles responsible for space positioning of the snail, Helix pomatia L. tentacle.
    Authors: Kiss Et al.
    PLoS One  2014;9:e109538
  16. Nicotine elicits prolonged calcium signaling along ventral hippocampal axons.
    Authors: Zhong Et al.
    Pharmacol Res Perspect  2013;8:e82719
  17. Striatal dopamine transmission is subtly modified in human A53Tα-synuclein overexpressing mice.
    Authors: Platt Et al.
    PLoS One  2012;7:e36397
  18. Gamma oscillations are generated locally in an attention-related midbrain network.
    Authors: Goddard Et al.
    Neuron  2012;73:567
  19. Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses.
    Authors: Caiati Et al.
    Sci Rep  2012;2:285
  20. Cytisine induces autonomic cardiovascular responses via activations of different nicotinic receptors.
    Authors: Li Et al.
    Auton Neurosci  2010;154:14
  21. Specific subtypes of nicotinic cholinergic receptors involved in sympathetic and parasympathetic cardiovascular responses.
    Authors: Li Et al.
    Neurosci Lett  2009;462:20
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