Catalog Number: 2349
Alternate Names: DHβE
Chemical Name: (2S,13bS)-2-Methoxy-2,3,5,6,8,9,10,13-octahydro-1H,12H-benzo[i]pyrano[3,4-g]indolizin-12-one hydrobromide
Biological Activity
Competitive nicotinic acetylcholine receptor antagonist with moderate selectivity for the neuronal α4 receptor subunit (IC50 values are 0.19 and 0.37 μM for α4β4 and α4β2 receptors respectively). Antagonizes behavioral effects of nicotine in vivo.
Technical Data
  • M.Wt:
    356.26
  • Formula:
    C16H21NO3.HBr
  • Solubility:
    Soluble to 100 mM in water and to 25 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Desiccate at RT
  • CAS No:
    29734-68-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Binding of the nicotinic cholinergic antagonist, dihydro-β-erythroidine, to rat brain tissue.
    Williams and Robinson
    J.Neurosci., 1984;4:2906
  2. In vivo pharmacological effects of dihydro-β-erythroidine, a nicotinic antagonist, in mice.
    Damaj et al.
    Psychopharmacology, 1995;117:67
  3. Multiple determinants of dihydro-β-erythroidine sensitivity on rat neuronal nicotinic receptor #945; subunits.
    Harvey et al.
    J.Neurochem., 1996;67:1953
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Dihydro-β-erythroidine hydrobromide include:

20 Citations: Showing 1 - 10
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  1. Differential processing of thalamic information via distinct striatal interneuron circuits.
    Authors: Assous
    Nat Commun 2017;8:15860
  2. Spontaneous Release Regulates Synaptic Scaling in the Embryonic Spinal Network In Vivo
    Authors: Miguel Angel Garcia-Bereguiain Et al.
    The Journal of Neuroscience 2016;6:7268
  3. Nicotinic and opioid receptor regulation of striatal dopamine D2-receptor mediated transmission
    Authors: Mamaligas Et al.
    Scientific Reports 2016;6:37834
  4. A cholinergic basal forebrain feeding circuit modulates appetite suppression
    Authors: Herman Et al.
    Nature 2016;538:253
  5. Nicotine evokes kinetic tremor by activating the inferior olive via α7 nicotinic acetylcholine receptors.
    Authors: Kunisawa Et al.
    Behav.Brain Res. 2016;314:173
  6. Acetylcholine induces GABA release onto rod bipolar cells through heteromeric nicotinic receptors expressed in A17 amacrine cells.
    Authors: Elgueta Et al.
    PLoS One 2015;9:6
  7. Insulin enhances striatal dopamine release by activating cholinergic interneurons and thereby signals reward.
    Authors: Stouffer Et al.
    Nat Commun 2015;6:8543
  8. Corelease of acetylcholine and GABA from cholinergic forebrain neurons.
    Authors: Saunders Et al.
    J Neurosci 2015;4
  9. Novel aspects of cholinergic regulation of colonic ion transport.
    Authors: Bader and Diener
    Elife 2015;3:e00139
  10. An Asymmetric Increase in Inhibitory Synapse Number Underlies the Development of a Direction Selective Circuit in the Retina.
    Authors: Morrie and Feller
    Neuroscience 2015;35:9281
  11. Functional Upregulation of α4* Nicotinic Acetylcholine Receptors in VTA GABAergic Neurons Increases Sensitivity to Nicotine Reward.
    Authors: Ngolab Et al.
    J Neurosci 2015;35:8570
  12. Absence of plateau potentials in dLGN cells leads to a breakdown in retinogeniculate refinement.
    Authors: Dilger Et al.
    J Neurosci 2015;35:3652
  13. Greater ethanol inhibition of presynaptic dopamine release in C57BL/6J than DBA/2J mice: Role of nicotinic acetylcholine receptors.
    Authors: Yorgason Et al.
    Front Cell Neurosci 2015;284:854
  14. Nicotinic acetylcholine receptors containing the α7-like subunit mediate contractions of muscles responsible for space positioning of the snail, Helix pomatia L. tentacle.
    Authors: Kiss Et al.
    PLoS One 2014;9:e109538
  15. Nicotine elicits prolonged calcium signaling along ventral hippocampal axons.
    Authors: Zhong Et al.
    Pharmacol Res Perspect 2013;8:e82719
  16. Striatal dopamine transmission is subtly modified in human A53Tα-synuclein overexpressing mice.
    Authors: Platt Et al.
    PLoS One 2012;7:e36397
  17. Gamma oscillations are generated locally in an attention-related midbrain network.
    Authors: Goddard Et al.
    Neuron 2012;73:567
  18. Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses.
    Authors: Caiati Et al.
    Sci Rep 2012;2:285
  19. Cytisine induces autonomic cardiovascular responses via activations of different nicotinic receptors.
    Authors: Li Et al.
    Auton Neurosci 2010;154:14
  20. Specific subtypes of nicotinic cholinergic receptors involved in sympathetic and parasympathetic cardiovascular responses.
    Authors: Li Et al.
    Neurosci Lett 2009;462:20
Expand to show all 20 Citations

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