Catalog Number: 0685
Chemical Name: (2S-cis)-3-(Acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one hydrochloride
Biological Activity
Antihypertensive and cardioprotective agent; an inhibitor of L-type Ca2+ channels.
Technical Data
  • M.Wt:
    450.98
  • Formula:
    C22H26N2O4S.HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    33286-22-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References

  1. Kishimoto T et al.
    Leucocyte Typing VI. Garland Publishing Inc. London.
  2. Inhibition of nicotinic receptor-mediated responses in bovine chromaffin cells by diltiazem.
    Gandia et al.
    Br.J.Pharmacol., 1996;118:1301
  3. Effects of diltiazem on bioenergetics, K+ gradients, and free cytosolic Ca2+ levels in rat brain synaptosomes submitted to energy metabolism inhibition and depolarization.
    Dagani et al.
    J.Neurochem., 1989;53:1379
  4. Molecular mechanisms of diltiazem interaction with L-type Ca2+ channels.
    Kraus et al.
    J.Biol.Chem., 1998;273:27205
  5. Block of P-type Ca2+ channels in freshly dissociated rat cerebellar Purkinje neurons by diltiazem and verapamil.
    Ishibashi et al.
    Brain Res., 1995;695:88
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Diltiazem hydrochloride include:

2 Citations: Showing 1 - 2
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  1. Abnormal excitability and episodic low-frequency oscillations in the cerebral cortex of the tottering mouse.
    Authors: Cramer Et al.
    PLoS One 2015;35:5664
  2. Dissecting out the complex Ca2+-mediated phenylephrine-induced contractions of mouse aortic segments.
    Authors: Fransen Et al.
    Brain Behav 2015;10:e0121634

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