Catalog Number: 3201
Alternate Names: Dimebone, Latrepirdine
Chemical Name: 2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridinyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride
Biological Activity
Non-selective antihistamine that displays cognitive enhancing abilities. Also displays high affinity for 5-HT (particularly 5-HT6 and 5-HT7), α-adrenergic, dopaminergic, AMPA and NMDA receptors, and L-type calcium channels. Does not inhibit acetylcholinesterase activity. Exhibits neuroprotective activity in cellular models of Alzheimer's and Huntington's disease and preserves cognitive function following administration to AF64A lesioned rats. Protects neurons against the neurotoxic action of β-amyloid fragment; shown to enhance autophagy in yeast and reduce intracellular Aβ42 levels.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Antihistamine agent dimebon as a novel neuroprotector and a cognitive enhancer.
    Bachurin et al.
    Ann.N.Y.Acad.Sci., 2001;939:425
  2. Dimebon is a 5-HT6 antagonist with acute cognitive enhancing activities.
    Schaffhauser et al.
    Biochem.Pharmacol., 2009;78:1035
  3. Latrepirdine (Dimebon) enhances autophagy and reduces intracellular GFP-Aβ42 levels in yeast.
    Bharadwaj et al.
    J.Alzheimers Dis., 2012;32:949
  4. From anti-allergic to anti-Alzheimer's: molecular pharmacology of dimebon.
    Okun et al.
    Curr.Alzheimer Res., 2009;7:97
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