Dimebon dihydrochloride

Catalog # Availability Size / Price Qty
3201/1
3201/10
Dimebon dihydrochloride | CAS No. 97657-92-6 | Amyloid beta Peptides
1 Image
Description: Neuroprotectant; protects against β-amyloid neurotoxicity
Alternative Names: Dimebone, Latrepirdine

Chemical Name: 2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridinyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride

Purity: ≥98%

Product Details
Reviews

Biological Activity

Non-selective antihistamine that displays cognitive enhancing abilities. Also displays high affinity for 5-HT (particularly 5-HT6 and 5-HT7), α-adrenergic, dopaminergic, AMPA and NMDA receptors, and L-type calcium channels. Does not inhibit acetylcholinesterase activity. Exhibits neuroprotective activity in cellular models of Alzheimer's and Huntington's disease and preserves cognitive function following administration to AF64A lesioned rats. Protects neurons against the neurotoxic action of β-amyloid fragment; shown to enhance autophagy in yeast and reduce intracellular Aβ42 levels.

Technical Data

M.Wt:
392.37
Formula:
C21H25N3.2HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
97657-92-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Latrepirdine (Dimebon) enhances autophagy and reduces intracellular GFP-Aβ42 levels in yeast.
    Bharadwaj et al.
    J.Alzheimers Dis., 2012;32:949
  2. Antihistamine agent dimebon as a novel neuroprotector and a cognitive enhancer.
    Bachurin et al.
    Ann.N.Y.Acad.Sci., 2001;939:425
  3. Dimebon is a 5-HT6 antagonist with acute cognitive enhancing activities.
    Schaffhauser et al.
    Biochem.Pharmacol., 2009;78:1035
  4. From anti-allergic to anti-Alzheimer's: molecular pharmacology of dimebon.
    Okun et al.
    Curr.Alzheimer Res., 2009;7:97
  5. Cognition-enhancing properties of dimebon in a rat novel object recognition task are unlikely to be associated with acetylcholinesterase inhibition or N-MthD.-aspartate receptor antagonism
    Giorgetti et al.
    J.Pharm.Exp.Ther., 2010;333:748

Product Datasheets

or select another batch:
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for Dimebon dihydrochloride

There are currently no reviews for this product. Be the first to review Dimebon dihydrochloride and earn rewards!

Have you used Dimebon dihydrochloride?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.