Disitertide
Tocris Bioscience | Catalog # 7717
TGF-β1 inhibitor
Discontinued Product
7717 has been discontinued.
View all TGF-beta 1 products.
Product Description
Disitertide is a transforming growth factor-beta 1 (TGF-β1) inhibitor. In vitro, it inactivates TGF-β1/Smads signaling which reduces cell migration and invasion without affecting cell proliferation in colorectal carcinoma cell lines (Lovo and SW480 cells).
Product Specifications for Disitertide
Molecular Weight
1580.83
Formula
C68H109N17O22S2
Storage
Store at -20°C
Purity
≥95% (HPLC)
CAS Number
272105-42-7
PubChem ID
9833838
InChI Key
IUYPEUHIWDMJLM-SWHDLQTQSA-N
SMILES
O=C(N[C@@H](CO)C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](C)C(N[C@@H](CO)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](C)C(N[C@@H](CCSC)C(N[C@@H](CCSC)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(N)=O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]([C@H](O)C)N
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Loading...
Solubility
| Solubility | Soluble to 1mg/ml in 0.01M PBS (pH 7.4) |
Calculators
Background References
References are publications that support the biological activity of the product.
- Qi PROTAC: An effective targeted protein degradation strategy for cancer therapy. Front.Pharmacol. 2021 PMID: 34025443
- Yao Activation of Slit2/Robo1 signaling promotes tumor metastasis in colorectal carcinoma through activation of the TGF-β/Smads pathway. Cells 2019 PMID: 31242633
- Feng Degradation of intracellular TGF-beta 1 by PROTACs efficiently reverses M2 macrophage induced malignant pathological events. Chem.Commun. 2020 PMID: 32037404
- Wu LINC00941 promotes CRC metastasis through preventing SMAD4 protein degradation and activating the TGF-β/SMAD2/3 signaling pathway. Cell Death Differ. 2021 PMID: 32737443
Product Documents for Disitertide
Certificate of Analysis
To download a Certificate of Analysis, please enter a lot or batch number in the search box below.
Product Specific Notices for Disitertide
For research use only
Related Research Areas
Citations for Disitertide
Customer Reviews for Disitertide
There are currently no reviews for this product. Be the first to review Disitertide and earn rewards!
Have you used Disitertide?
Submit a review and receive an Amazon gift card!
$25/€18/£15/$25CAN/¥2500 Yen for a review with an image
$10/€7/£6/$10CAN/¥1110 Yen for a review without an image
Submit a review
Loading...
Associated Pathways
IL-21 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types
Mesenchymal Stem Cell Differentiation Pathways & Lineage-specific Markers
TGF-beta Signaling Pathways
Th17 Differentiation Pathway