Home / BMP and Other Activin Receptor Inhibitors / DMH-1

DMH-1

Catalog #: 4126
21 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4126/10
4126/50
DMH-1 | CAS No. 1206711-16-1 | BMP and Other Activin Receptor Inhibitors
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Description: Selective ALK2 inhibitor

Chemical Name: 4-[6-[4-(1-Methylethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline

Purity: ≥98%

Product Details
Citations (21)
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Biological Activity

DMH-1 is a selective inhibitor of bone morphogenic protein (BMP) type-I receptor activin receptor-like kinase 2 (ALK2) receptor (IC50 = 108 nM or 12.6 nM in in vitro kinase assays). DMH-1 exhibits 6- and 19-fold selectivity for ALK-2 over ALK-1 and ALK-3, respectively, and no significant inhibition of AMPK, ALK5, KDR (VEGFR-2) or PDGFRβ receptors. DMH-1 blocks BMP4-induced phosphorylation of Smads 1, 5 and 8 in HEK293 cells. Promotes neurogenesis in human induced pluripotent stem cells (iPSCs) when used in combination with SB 431542 (Cat. No. 1614). DMH-1 suppresses lung cancer cell proliferation, migration, invasion in vitro and reduces tumor growth in a mouse lung cancer xenograft model. DMH-1 inhibits cellular autophagy responses. DMH-1 induces intestinal differentiation in human intestinal organoids (hIOs) derived from human pluripotent stems cells (hPSCs). The compound can also be used in protocols for the chemical reprogramming of somatic cells to iPSCs.

Technical Data

M.Wt:
380.44
Formula:
C24H20N4O
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1206711-16-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for DMH-1

The citations listed below are publications that use Tocris products. Selected citations for DMH-1 include:

21 Citations: Showing 1 - 10

  1. An airway organoid-based screen identifies a role for the HIF1α-glycolysis axis in SARS-CoV-2 infection.
    Authors: Duan Et al.
    Cell Rep.  2021;37:109920
  2. Human Stem Cell-Derived Neurons Repair Circuits and Restore Neural Function
    Authors: Xiong Et al.
    Cell Stem Cell  2021;28:112
  3. Efficient Generation of Trunk Neural Crest and Sympathetic Neurons from Human Pluripotent Stem Cells Via a Neuromesodermal Axial Progenitor Intermediate.
    Authors: Frith and Tsakiridis
    Curr Protoc Stem Cell Biol  2019;49:e81
  4. Core Transcription Factors Promote Induction of PAX3-Positive Skeletal Muscle Stem Cells.
    Authors: Sato Et al.
    Stem Cell Reports  2019;13:352
  5. FGF Modulates the Axial Identity of Trunk hPSC-Derived Neural Crest but Not the Cranial-Trunk Decision.
    Authors: Hackland Et al.
    Stem Cell Reports  2019;12:920
  6. Activating a Reserve Neural Stem Cell Population In Vitro Enables Engraftment and Multipotency after Transplantation.
    Authors: Peterson Et al.
    Stem Cell Reports  2019;12:680
  7. A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation.
    Authors: Sheng Et al.
    Nat Commun  2018;9:4047
  8. Expansion of Airway Basal Cells and Generation of Polarized Epithelium.
    Authors: Levardon Et al.
    Bio Protoc  2018;8
  9. Myoepithelial Cells of Submucosal Glands Can Function as Reserve Stem Cells to Regenerate Airways after Injury.
    Authors: Tata Et al.
    Cell Stem Cell  2018;22:668
  10. Submucosal Gland Myoepithelial Cells Are Reserve Stem Cells That Can Regenerate Mouse Tracheal Epithelium.
    Authors: Lynch Et al.
    Cell Stem Cell  2018;22:653
  11. The COPII cargo adapter SEC24C is essential for neuronal homeostasis.
    Authors: Wang Et al.
    J Clin Invest  2018;128:3319
  12. Fast Generation of Functional Subtype Astrocytes from Human Pluripotent Stem Cells.
    Authors: Li Et al.
    Stem Cell Reports  2018;11:998
  13. Induced Pluripotent Stem Cell-Derived Dopaminergic Neurons from Adult Common Marmoset Fibroblasts.
    Authors: Vermilyea Et al.
    Stem Cells Dev  2017;26:1225
  14. Generation of serotonin neurons from human pluripotent stem cells.
    Authors: Lu Et al.
    Nat Biotechnol  2016;34:89
  15. Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells
    Authors: Mou Et al.
    Cell Stem Cell  2016;19:217
  16. Generation and expansion of highly pure motor neuron progenitors from human pluripotent stem cells.
    Authors: Du Et al.
    Nat.Commun.  2015;6:6626
  17. Blockade of bone morphogenetic protein signaling potentiates the pro-inflammatory phenotype induced by interleukin-17 and tumor necrosis factor-α combination in rheumatoid synoviocytes.
    Authors: Varas Et al.
    Lab Chip  2015;17:192
  18. Myocardin-related transcription factor A regulates conversion of progenitors to beige adipocytes.
    Authors: McDonald Et al.
    Arthritis Res Ther  2015;160:105
  19. The BMP Pathway Participates in Human Naive CD4+ T Cell Activation and Homeostasis.
    Authors: Martínez Et al.
    Cell  2015;10:e0131453
  20. Directed differentiation of forebrain GABA interneurons from human pluripotent stem cells.
    Authors: Liu Et al.
    Nat Protoc  2013;8:1670
  21. Flow-based pipeline for systematic modulation and analysis of 3D tumor microenvironments.
    Authors: Li Et al.
    J Biol Chem  2013;13:1969

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VersaClone cDNA Plasmids

Human Activin RIA/ALK-2 (NP_001096) VersaClone cDNA

RDC1201

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