Chemical Name: 4-[6-[4-(1-Methylethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline
Biological ActivityDMH-1 is a selective inhibitor of bone morphogenic protein (BMP) type-I receptor activin receptor-like kinase 2 (ALK2) receptor (IC50 = 108 nM [Hao et al., 2010] or 12.6 nM [Mohedas et al., 2013] in in vitro kinase assays). Exhibits 6- and 19-fold selectivity for ALK-2 over ALK-1 and ALK-3, respectively, and no significant inhibition of AMPK, ALK5, KDR (VEGFR-2) or PDGFRβ receptors. Blocks BMP4-induced phosphorylation of Smads 1, 5 and 8 in HEK293 cells. Promotes neurogenesis in human induced pluripotent stem cells (iPSCs) when used in combination with SB 431542 (Cat. No. 1614).
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Development of an ALK2-biased BMP type I receptor kinase inhibitor.
Mohedas et al.
ACS Chem.Biol., 2013;8:1291
DMH1, a highly selective small molecule BMP inhibitor, promotes neurogenesis of hiPSCs: comparison of PAX6 and SOX1 expression during neural induction.
Neely et al.
ACS Chem.Neurosci., 2012;3:482
Swimming into the future of drug discovery: in vivo chemical screens in zebrafish.
Bowman and Zon
ACS Chem.Biol., 2010;5:159
In vivo structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors.
Hao et al.
ACS Chem.Biol., 2010;5:245
Citations for DMH-1
The citations listed below are publications that use Tocris products. Selected citations for DMH-1 include:
20 Citations: Showing 1 - 10
Human Stem Cell-Derived Neurons Repair Circuits and Restore Neural Function
Authors: Xiong Et al.
Cell Stem Cell 2021;28:112
Efficient Generation of Trunk Neural Crest and Sympathetic Neurons from Human Pluripotent Stem Cells Via a Neuromesodermal Axial Progenitor Intermediate.
Authors: Frith and Tsakiridis
Curr Protoc Stem Cell Biol 2019;:e81
Core Transcription Factors Promote Induction of PAX3-Positive Skeletal Muscle Stem Cells.
Authors: Sato Et al.
Stem Cell Reports 2019;13:352
FGF Modulates the Axial Identity of Trunk hPSC-Derived Neural Crest but Not the Cranial-Trunk Decision.
Authors: Hackland Et al.
Stem Cell Reports 2019;12:920
Activating a Reserve Neural Stem Cell Population In Vitro Enables Engraftment and Multipotency after Transplantation.
Authors: Peterson Et al.
Stem Cell Reports 2019;12:680
A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation.
Authors: Sheng Et al.
Nat Commun 2018;9:4047
Expansion of Airway Basal Cells and Generation of Polarized Epithelium.
Authors: Levardon Et al.
Bio Protoc 2018;8
Myoepithelial Cells of Submucosal Glands Can Function as Reserve Stem Cells to Regenerate Airways after Injury.
Authors: Tata Et al.
Cell Stem Cell 2018;22:668
Submucosal Gland Myoepithelial Cells Are Reserve Stem Cells That Can Regenerate Mouse Tracheal Epithelium.
Authors: Lynch Et al.
Cell Stem Cell 2018;22:653
The COPII cargo adapter SEC24C is essential for neuronal homeostasis.
Authors: Wang Et al.
J Clin Invest 2018;128:3319
Fast Generation of Functional Subtype Astrocytes from Human Pluripotent Stem Cells.
Authors: Li Et al.
Stem Cell Reports 2018;11:998
Induced Pluripotent Stem Cell-Derived Dopaminergic Neurons from Adult Common Marmoset Fibroblasts.
Authors: Vermilyea Et al.
Stem Cells Dev 2017;26:1225
Generation of serotonin neurons from human pluripotent stem cells.
Authors: Lu Et al.
Nat Biotechnol 2016;34:89
Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells
Authors: Mou Et al.
Cell Stem Cell 2016;19:217
Generation and expansion of highly pure motor neuron progenitors from human pluripotent stem cells.
Authors: Du Et al.
Blockade of bone morphogenetic protein signaling potentiates the pro-inflammatory phenotype induced by interleukin-17 and tumor necrosis factor-α combination in rheumatoid synoviocytes.
Authors: Varas Et al.
Lab Chip 2015;17:192
Myocardin-related transcription factor A regulates conversion of progenitors to beige adipocytes.
Authors: McDonald Et al.
Arthritis Res Ther 2015;160:105
The BMP Pathway Participates in Human Naive CD4+ T Cell Activation and Homeostasis.
Authors: Martínez Et al.
Directed differentiation of forebrain GABA interneurons from human pluripotent stem cells.
Authors: Liu Et al.
Nat Protoc 2013;8:1670
Flow-based pipeline for systematic modulation and analysis of 3D tumor microenvironments.
Authors: Li Et al.
J Biol Chem 2013;13:1969
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I used it grow primary human and mouse airway basal cells
I used it grow human airway basal cells