Dolasetron mesylate

   
Product Datasheet
Catalog Number:5629
Chemical Name:3-Oxooctahydro-2,6-methano-2H-quinolizin-8-yl 1H-indole-3-carboxylate methanesulfonate
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Biological Activity
Potent and selective 5-HT3 receptor antagonist (pIC50 = 7.55). Exhibits 200-fold selectivity for 5-HT3 over 5-HT1A, 5-HT1B and 5-HT2 receptors, and a range of other GPCRs. Blocks the 5-HT-elicited von Bezold-Jarisch reflex in rats and suppresses cisplatin-induced vomiting in ferrets.
Technical Data
  • M.Wt:
    420.48
  • Formula:
    C19H20N2O3.CH3SO3H
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at +4°C
  • CAS No:
    115956-13-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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