Catalog Number: 0508
Chemical Name: 11-(3-dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepin hydrochloride
Biological Activity
Highly potent H1 histamine receptor antagonist (Kd = 310 pM) and tricyclic antidepressant. Also binds to the H4 histamine receptor (pKi = 6.79).

This compound is a mixture of E/Z isomers (ratio: 85:15).

Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
  • This compound is a mixture of E/Z isomers (ratio: 85:15)
Background References

  1. Kishimoto T et al.
    Leucocyte Typing VI. Garland Publishing Inc. London.
  2. Review of clinical and animal studies comparing the cardiovascular effects of doxepin and other tricyclic antidepressants.
    Am.J.Psychiatry, 1983;140:1006
  3. Discovery of a novel member of the histamine receptor family.
    Nguyen et al.
    Mol.Pharmacol., 2001;59:427
  4. [3H]Doxepin interactions with histamine H1-receptors and other sites in guinea pig brain homogenates.
    Tran et al.
    Eur.J.Pharmacol., 1981;70:501

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