Doxepin hydrochloride

Biological Activity

This compound is a mixture of E/Z isomers (ratio: 85:15).

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Background References

1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
   Fox JT, Sakamuru S, Huang R
   Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
2. Discovery of a novel member of the histamine receptor family.
   Nguyen et al.
   Mol.Pharmacol., 2001;59:427
3. [³H]Doxepin interactions with histamine H₁-receptors and other sites in guinea pig brain homogenates.
   Tran et al.
   Eur.J.Pharmacol., 1981;70:501
4. Review of clinical and animal studies comparing the cardiovascular effects of dox. and other tricyclic antidepressants.
   Lurchins
   Am.J.Psychiatry, 1983;140:1006

Product Datasheets