Highly potent H1
histamine receptor antagonist (Kd
= 310 pM) and tricyclic antidepressant. Also binds to the H4
histamine receptor (pKi
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Other Product-Specific Information:
- This compound is a mixture of E/Z isomers (ratio: 85:15)
Kishimoto T et al.
Leucocyte Typing VI. Garland Publishing Inc. London.
Review of clinical and animal studies comparing the cardiovascular effects of doxepin and other tricyclic antidepressants.
Discovery of a novel member of the histamine receptor family.
Nguyen et al.
[3H]Doxepin interactions with histamine H1-receptors and other sites in guinea pig brain homogenates.
Tran et al.