Chemical Name: 3,4,5-Trihydroxybenzoic acid (2R,3R)-3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3-yl ester
Biological ActivityEGCG is a β-secretase (BACE1) inhibitor (IC50 = 1.6 μM); inhibits amyloid assembly. Inhibits the formation of amyloid fibrils by proteins such as Aβ, α-synuclein and huntingtin. Reduces Aβ42-induced cell death in three different cell types. Also inhibits glutamate dehydrogenase. Inhibits cell growth and selectively induces apoptosis in A431 and human pancreatic cancer cells. Also a DNMT1 inhibitor.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Mechanisms for the inhibition of DNA methyltransferases by tea catechins and bioflavonoids.
Lee et al.
Comparison of three amyloid assembly inhibitors: the sugar scyllo-inositol, the polyphenol epigallocatechin gallate, and the molecular tweezer CLR01.
Sinha et al.
ACS Chem.Neurosci., 2012;3:451
EGCG inhibits growth, invasion, angiogenesis and metastastasis of pancreatic cancer.
Shankar et al.
Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling.
Yang et al.
Cancer Res., 2009;69:7986
Green tea catechins as a BACE1 (β-secretase) inhibitor.
Jeon et al.
Green tea polyphenol epigallocatechin-3-gallate differentially modulates nuclear factor κB in cancer cells versus normal cells.
Ahmad et al.
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for EGCG
Average Rating: 4.3 (Based on 3 Reviews)
Have you used EGCG?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
10 μM EGCG
This was used to elute purine binding proteins from cell lysate. The drug gave no visible bands from eluted proteins examined on silver stain.
Has expected effect on cells.