Chemical Name: 3,4,5-Trihydroxybenzoic acid (2R,3R)-3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3-yl ester
Biological Activityβ-secretase (BACE1) inhibitor (IC50 = 1.6 μM); inhibits amyloid assembly. Inhibits the formation of amyloid fibrils by proteins such as Aβ, α-synuclein and huntingtin. Reduces Aβ42-induced cell death in three different cell types. Also inhibits glutamate dehydrogenase. Inhibits cell growth and selectively induces apoptosis in A431 and human pancreatic cancer cells. Also a DNMT1 inhibitor.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Mechanisms for the inhibition of DNA methyltransferases by tea catechins and bioflavonoids.
Lee et al.
Green tea catechins as a BACE1 (β-secretase) inhibitor.
Jeon et al.
Comparison of three amyloid assembly inhibitors: the sugar scyllo-inositol, the polyphenol epigallocatechin gallate, and the molecular tweezer CLR01.
Sinha et al.
ACS Chem.Neurosci., 2012;3:451
Green tea polyphenol epigallocatechin-3-gallate differentially modulates nuclear factor κB in cancer cells versus normal cells.
Ahmad et al.
EGCG inhibits growth, invasion, angiogenesis and metastastasis of pancreatic cancer.
Shankar et al.
Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling.
Yang et al.
Cancer Res., 2009;69:7986
Citations for EGCG
The citations listed below are publications that use Tocris products. Selected citations for EGCG include:
5 Citations: Showing 1 - 5
Cyclized NDGA modifies dynamic α-synuclein monomers preventing aggregation and toxicity.
Authors: Daniels Et al.
Sci Rep 2019;9:2937
Aβ42 fibril formation from predominantly oligomeric samples suggests a link between oligomer heterogeneity and fibril polymorphism.
Authors: Xue Et al.
R Soc Open Sci 2019;6:190179
Epigallocatechin-3-Gallate (EGCG) Suppresses Pancreatic Cancer Cell Growth, Invasion, and Migration partly through the Inhibition of Akt Pathway and Epithelial-Mesenchymal Transition: Enhanced Efficacy when Combined with Gemcitabine.
Authors: Wei Et al.
LKB1 loss links serine metabolism to DNA methylation and tumorigenesis.
Authors: Kottakis Et al.
Synergistic effect of curcumin on epigallocatechin gallate-induced anticancer action in PC3 prostate cancer cells.
Authors: Eom Et al.
Allergy Asthma Immunol Res 2015;48:461
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10 μM EGCG
This was used to elute purine binding proteins from cell lysate. The drug gave no visible bands from eluted proteins examined on silver stain.
Has expected effect on cells.