Inhibitor of amyloid assembly; inhibits the formation of amyloid fibrils by proteins such as Aβ
-synuclein and huntingtin. Reduces Aβ
42-induced cell death in three different cell types. Also inhibits β
= 1.6 μ
M) and glutamate dehydrogenase GDH. Inhibits cell growth and selectively induces apoptosis in A431 and human pancreatic cancer cells. Also a DNMT1 inhibitor.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Mechanisms for the inhibition of DNA methyltransferases by tea catechins and bioflavonoids.
Lee et al.
Green tea catechins as a BACE1 (β-secretase) inhibitor.
Jeon et al.
Comparison of three amyloid assembly inhibitors: the sugar scyllo-inositol, the polyphenol epigallocatechin gallate, and the molecular tweezer CLR01.
Sinha et al.
ACS Chem.Neurosci., 2012;3:451
Green tea polyphenol epigallocatechin-3-gallate differentially modulates nuclear factor κB in cancer cells versus normal cells.
Ahmad et al.
EGCG inhibits growth, invasion, angiogenesis and metastastasis of pancreatic cancer.
Shankar et al.
Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling.
Yang et al.
Cancer Res., 2009;69:7986
The citations listed below are publications that use Tocris products. Selected citations for EGCG include:
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