EGCG

Catalog # Availability Size / Price Qty
4524/50
EGCG | CAS No. 989-51-5 | Amyloid beta Peptide Inhibitors
1 Image
Description: β-secretase (BACE) inhibitor; inhibits amyloid assembly
Alternative Names: Epigallocatechin gallate

Chemical Name: 3,4,5-Trihydroxybenzoic acid (2R,3R)-3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3-yl ester

Purity: ≥98%

Product Details
Citations (5)
Reviews (3)

Biological Activity

β-secretase (BACE1) inhibitor (IC50 = 1.6 μM); inhibits amyloid assembly. Inhibits the formation of amyloid fibrils by proteins such as Aβ, α-synuclein and huntingtin. Reduces Aβ42-induced cell death in three different cell types. Also inhibits glutamate dehydrogenase. Inhibits cell growth and selectively induces apoptosis in A431 and human pancreatic cancer cells. Also a DNMT1 inhibitor.

Technical Data

M.Wt:
458.37
Formula:
C22H18O11
Solubility:
Soluble to 10 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
989-51-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Or select another batch:
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for EGCG

Average Rating: 4.3 (Based on 3 Reviews)

5 Star
66.67%
4 Star
0%
3 Star
33.33%
2 Star
0%
1 Star
0%

Have you used EGCG?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


We got expected effect on cells
By Anonymous on 04/03/2020
Application: Species: Mouse

10 μM EGCG


Showed no visible purine elusions.
By Scott Scarneo on 02/06/2019
Application: Species: Human

This was used to elute purine binding proteins from cell lysate. The drug gave no visible bands from eluted proteins examined on silver stain.


EGCG
By Anonymous on 05/17/2018
Application: Species: Human

Has expected effect on cells.


Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.