epithelial Sodium Channel beta Antibody - BSA Free

Novus Biologicals | Catalog # NBP3-18257

Novus Biologicals
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Key Product Details

Species Reactivity

Human, Mouse, Rat, Hamster, Xenopus

Applications

Immunohistochemistry, Western Blot, Immunocytochemistry/ Immunofluorescence, Immunoprecipitation

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free
View all epithelial Sodium Channel beta Primary Antibodies »

Product Specifications

Immunogen

Produced against the C-terminal tail (amino acids 617-638) of rat beta ENaC (antibody designation 3755-2)

Localization

Apical Cell Membrane

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for epithelial Sodium Channel beta Antibody - BSA Free

Western Blot: epithelial Sodium Channel beta Antibody [NBP3-18257]

Western Blot: epithelial Sodium Channel beta Antibody [NBP3-18257]

Western Blot: epithelial Sodium Channel beta Antibody [NBP3-18257] - Western blot analysis of Mouse mpkCCD cell lysates showing detection of epithelial Sodium Channel beta protein using Rabbit Anti-epithelial Sodium Channel beta Polyclonal Antibody (NBP3-18257). Primary Antibody: Rabbit Anti-epithelial Sodium Channel beta Polyclonal Antibody (NBP3-18257) at 1:1000.
Immunohistochemistry: epithelial Sodium Channel beta Antibody [NBP3-18257]

Immunohistochemistry: epithelial Sodium Channel beta Antibody [NBP3-18257]

Immunohistochemistry: epithelial Sodium Channel beta Antibody [NBP3-18257] - Immunohistochemistry analysis using Rabbit Anti-epithelial Sodium Channel beta Polyclonal Antibody (NBP3-18257). Tissue: kidney tissue. Species: Rat. Primary Antibody: Rabbit Anti-epithelial Sodium Channel beta Polyclonal Antibody (NBP3-18257) at 1:100. Secondary Antibody: FITC Goat Anti-Rabbit (green).
Western Blot: epithelial Sodium Channel beta Antibody [NBP3-18257]

Western Blot: epithelial Sodium Channel beta Antibody [NBP3-18257]

Western Blot: epithelial Sodium Channel beta Antibody [NBP3-18257] - Western blot analysis of Rat kidney tissue lysates showing detection of epithelial Sodium Channel beta protein using Rabbit Anti-epithelial Sodium Channel beta Polyclonal Antibody (NBP3-18257). Primary Antibody: Rabbit Anti-epithelial Sodium Channel beta Polyclonal Antibody (NBP3-18257) at 1:1000.
Western Blot: epithelial Sodium Channel beta Antibody [NBP3-18257]

Western Blot: epithelial Sodium Channel beta Antibody [NBP3-18257]

Western Blot: epithelial Sodium Channel beta Antibody [NBP3-18257] - Western blot analysis of Mouse kidney cortex showing detection of epithelial Sodium Channel beta protein using Rabbit Anti-epithelial Sodium Channel beta Polyclonal Antibody (NBP3-18257). Primary Antibody: Rabbit Anti-epithelial Sodium Channel beta Polyclonal Antibody (NBP3-18257) at 1:1000. Low-salt diet (lanes 1-4) compared to a high-salt diet (lanes 5-8).

Applications for epithelial Sodium Channel beta Antibody - BSA Free

Application
Recommended Usage

Immunohistochemistry

1:100

Western Blot

1:1000
Application Notes
Optimal dilutions for assays should be determined by the user.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS, 50% glycerol

Format

BSA Free

Preservative

0.09% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: epithelial Sodium Channel beta

SCNN1B is a subunit of the epithelial sodium channel, ENaC. ENac has high sodium selectivity, low conductance, and amiloride sensitivity. The functional channel of ENaC is composed of at least 3 subunits, alpha (SCNN1A), beta (SCNN1B), and gamma (SCNN1G). The 3 subunits show sequence similarities to one another, indicating descent from a common ancestral gene. Each encodes a protein containing 2 transmembrane domains, with intracellular amino and carboxyl termini. ENaC in the kidney, lung and colon plays an essential role in trans- epithelial sodium and fluid balance. ENaC also mediates aldosterone-dependent sodium re-uptake in the distal nephron of the kidney, thus regulating blood pressure. Mutations in beta or gamma subunit of the epithelial sodium channel (ENaC) have been found to cause a hereditary form of human hypertension, Liddle syndrome.

Long Name

Amiloride-sensitive sodium channel subunit beta

Alternate Names

Beta-ENaC, Beta-NaCH, ENaCB, SCNEB, SCNN1B

Gene Symbol

SCNN1B

Additional epithelial Sodium Channel beta Products

Product Documents for epithelial Sodium Channel beta Antibody - BSA Free

Certificate of Analysis

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Product Specific Notices for epithelial Sodium Channel beta Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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