Catalog Number: 4696
Alternate Names: SK&F 108566
Chemical Name: (αE)-α-[[2-Butyl-1-[(4-carboxyphenyl)methyl]-1H-imidazol-5-yl]methylene]-2-thiophenepropanoic acid methanesulfonate
Biological Activity
Potent angiotensin II receptor 1 (AT1) antagonist (IC50 values are 1.5, 1.7, 3.9 and 9.2 nM at rat mesenteric artery, human liver membrane, human adrenal cortical membrne and rat adrenal cortical membrane respectively). Displays no effect on vasopressin or CGRP binding, or angiotensin-converting enzyme (ACE) activity. Inhibits the angiotensin II-induced pressor response in normotensive rats.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 20 mM in ethanol
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Angiotensin II inhibits insulin binding to endothelial cells.
    Oh et al.
    Diabetes Metab.J., 2011;35:243
  2. Pharmacological characterization of the nonpeptide angiotensin II receptor antagonist, SK&F 108566.
    Edwards et al.
    J.Pharmacol.Exp.Ther., 1992;260:175
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