Catalog Number: 4495
Alternate Names: (R)-Flurbiprofen
Chemical Name: (R)-2-Fluoro-α-methyl[1,1'-biphenyl]-4-acetic acid
Biological Activity
Nonsteroidal anti-inflammatory drug (NSAID) that inhibits γ-secretase activity. Selectively lowers Aβ42 levels in human neuroglioma cells; displays no effect on Aβ40 levels at a concentration of 100 μM.
Technical Data
  • M.Wt:
    244.26
  • Formula:
    C15H13FO2
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    51543-40-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. NSAIDs and enantiomers of flurbiprofen target γ-secretase and lower Aβ42 in vivo.
    Eriksen et al.
    J.Clin.Invest., 2003;112:440
  2. Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice.
    Kukar et al.
    BMC Neurosci., 2007;8:54

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