Nonsteroidal anti-inflammatory drug (NSAID) that inhibits γ
-secretase activity. Selectively lowers Aβ
42 levels in human neuroglioma cells; displays no effect on Aβ
40 levels at a concentration of 100 μ
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NSAIDs and enantiomers of flurbiprofen target γ-secretase and lower Aβ42 in vivo.
Eriksen et al.
Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice.
Kukar et al.
BMC Neurosci., 2007;8:54