Chemical Name: (R)-2-Fluoro-α-methyl[1,1'-biphenyl]-4-acetic acid
Biological ActivityNonsteroidal anti-inflammatory drug (NSAID) that inhibits γ-secretase activity. Selectively lowers Aβ42 levels in human neuroglioma cells; displays no effect on Aβ40 levels at a concentration of 100 μM.
The technical data provided above is for guidance only.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice.
Kukar et al.
BMC Neurosci., 2007;8:54
NSAIDs and enantiomers of flurbip. target γ-secretase and lower Aβ42 in vivo.
Eriksen et al.
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