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Fumitremorgin C

Catalog #: 2876 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2876/250U
Fumitremorgin C | CAS No. 118974-02-0 | Multidrug Transporter Inhibitors
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Description: Inhibitor of BCRP-mediated multidrug resistance

Chemical Name: (5aS,12S,14aS)-1,2,3,5a,6,11,12,14a-Octahydro-9-methoxy-12-(2-methyl-1-propen-1-yl)-5H,14H-pyrrolo[1'',2'':4',5']pyrazino[1',2':1,6]pyrido[3,4-b]indole-5,14-dione

Purity: ≥98%

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Biological Activity

Fumitremorgin C is a chemosensitizing agent; selectively reverses BCRP-mediated multidrug resistance to mitoxantrone (Cat. No. 4250), doxorubicin (Cat. No. 2252) and topotecan (Cat. No. 4562) in transfected MCF-7 cells. Does not reverse resistance in P-gp- or MRP-positive cells. Analog (Ko 143, Cat. No. 3241) also available.

Technical Data

M.Wt:
379.45
Formula:
C22H25N3O3
Solubility:
Soluble to 10 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
118974-02-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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VersaClone cDNA Plasmids

Human BCAM (NP_005572) VersaClone cDNA

RDC1666

Mouse BCAM (NP_065232) VersaClone cDNA

RDC1871

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