Ko 143

  ( 10 citations )    
Product Datasheet
Catalog Number:3241
Chemical Name:(3S,6S,12aS)-1,2,3,4,6,7,12,12a-Octahydro-9-methoxy-6-(2-methylpropyl)-1,4-dioxopyrazino[1',2':1,6]pyrido[3,4-b]indole-3-propanoic acid 1,1-dimethylethyl ester
Product Details
Citations (10)
Supplemental Products
Reviews
Biological Activity
Potent and selective breast cancer resistance protein multidrug transporter (BCRP) inhibitor (EC90 = 26 nM). Displays > 200-fold selectivity over P-gp and MRP-1 transporters. Increases intracellular drug accumulation and reverses BCRP-mediated multidrug resistance. Inhibits ABCB1 and ABCC1 at higher concentrations. Rapidly metabolized in rat plasma.
Technical Data
  • M.Wt:
    469.57
  • Formula:
    C26H35N3O5
  • Solubility:
    Soluble to 50 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >99
  • Storage:
    Store at -20°C
  • CAS No:
    461054-93-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
COA view current batch
or select another batch:
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Ko 143 include:

10 Citations: Showing 1 - 10
Filter your results:

  1. Bioluminescent imaging of ABCG2 efflux activity at the blood-placenta barrier.
    Authors: Kumar Et al.
    Sci Rep  2016;6:20418
  2. ABCG2 Transporter Expression Impacts Group 3 Medulloblastoma Response to Chemotherapy.
    Authors: Morfouace Et al.
    Cancer Res  2015;75:3879
  3. Raltegravir permeability across blood-tissue barriers and the potential role of drug efflux transporters.
    Authors: Hoque Et al.
    Biochem Pharmacol  2015;59:2572
  4. FL118, a novel camptothecin derivative, is insensitive to ABCG2 expression and shows improved efficacy in comparison with irinotecan in colon and lung cancer models with ABCG2-induced resistance.
    Authors: Westover Et al.
    Brain Res  2015;14:92
  5. Structural determinants of peripheral O-arylcarbamate FAAH inhibitors render them dual substrates for Abcb1 and Abcg2 and restrict their access to the brain.
    Authors: Moreno-Sanz Et al.
    Pharmacol Res  2014;87:87
  6. Characterisation of the roles of ABCB1, ABCC1, ABCC2 and ABCG2 in the transport and pharmacokinetics of actinomycin D in vitro and in vivo.
    Authors: Hill Et al.
    J Biol Chem  2013;85:29
  7. EZN-2208 (PEG-SN38) overcomes ABCG2-mediated topotecan resistance in BRCA1-deficient mouse mammary tumors.
    Authors: Zander Et al.
    PLoS One  2012;7:e45248
  8. The transport of nifurtimox, an anti-trypanosomal drug, in an in vitro model of the human blood-brain barrier: evidence for involvement of breast cancer resistance protein.
    Authors: Watson Et al.
    Antimicrob Agents Chemother  2012;1436:111
  9. Erlotinib antagonizes ABC transporters in acute myeloid leukemia.
    Authors: Lainey Et al.
    Cell Cycle  2012;11:4079
  10. The ABC membrane transporter ABCG2 prevents access of FAAH inhibitor URB937 to the central nervous system.
    Authors: Moreno-Sanz Et al.
    Pharmacol Res  2011;64:359

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Have you used Ko 143?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Contact Us to Order
reload

Feedback

Customer Information
Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee