Chemical Name: 3-(3,4,5-Trihydroxybenzoyloxy)naphthalen-1-yl 3,4,5-trihydroxybenzoate
Biological ActivityG 28UCM is a FASN inhibitor. Inhibits breast cancer cell proliferation in vitro (IC50 values are 21 - 79 μM), including cell lines resistant to anti-HER2 therapies. Blocks HER2 signaling and induces apoptosis. Inhibits growth of breast cancer xenografts in mice without causing anorexia.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
A novel inhibitor of fatty acid synthase shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines.
Puig et al.
Breast Cancer Res., 2011;13:R131
Novel inhibitors of fatty acid synthase with anticancer activity.
Puig et al.
Clin.Cancer Res., 2009;15:7608
Citation for G 28UCM
The citations listed below are publications that use Tocris products. Selected citations for G 28UCM include:
1 Citation: Showing 1 - 1
Pharmacological inhibition of fatty acid synthesis blocks SARS-CoV-2 replication.
Authors: Chu Et al.
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