Inhibitor of PCAF and p300 histone acetyltransferase (HAT) activity (IC50
values are 5 and 7 μ
M, respectively). Promotes expansion of human HSCs ex vivo
. Causes reversal of EMT and inhibits β
-catenin in breast cancer cell lines MDA-MB-231 and BT-549.
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Garcinol regulates EMT and Wnt signaling pathways in vitro and in vivo, leading to anticancer activity against breast cancer cells.
Ahmad et al.
Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression.
Balasubramanyam et al.
Ex vivo expansion of human hematopoietic stem cells by garcinol, a potent inhibitor of histone acetyltransferase.
Nishino et al.
PLoS One, 2011;6:e24298