GSK 650394

Tocris Bioscience | Catalog # 3572

Serum- and glucocorticoid-regulated kinase (SGK) inhibitor
Tocris Bioscience

Key Product Details

Description

Serum- and glucocorticoid-regulated kinase (SGK) inhibitor
View all Other Kinase Inhibitors »

Product Description

GSK 650394 is a serum- and glucocorticoid-regulated kinase 1 (SGK1) inhibitor (IC50 values are 62 and 103 nM for SGK1 and SGK2 respectively). Displays >30-fold selectivity over Akt and other related kinases. Inhibits androgen-stimulated growth of LNCaP cells, a human prostate carcinoma cell line (IC50 ~ 1 μM).

Licensing Information

Sold with the permission of GlaxoSmithKline

Product Specifications for GSK 650394

Molecular Weight

382.45

Formula

C25H22N2O2

Storage

Store at RT

Purity

≥97% (HPLC)

Chemical Name

2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl-benzoic acid

CAS Number

890842-28-1

PubChem ID

25022668

InChI Key

WVSBGSNVCDAMCF-UHFFFAOYSA-N

SMILES

O=C(C(C(C5CCCC5)=C4)=CC=C4C2=CNC1=NC=C(C3=CC=CC=C3)C=C12)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 38.24 100

Preparing Stock Solutions for GSK 650394

The following data is based on the product molecular weight 382.45.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.61 mL 13.07 mL 26.15 mL
5 mM 0.52 mL 2.61 mL 5.23 mL
10 mM 0.26 mL 1.31 mL 2.61 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 83 publications citing the usage of this product.

Product Documents for GSK 650394

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for GSK 650394

For research use only

Customer Reviews for GSK 650394 (1)

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  • We got expected effect
    Name: Ashish Juvekar
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: HCC1937
    Verified Customer | Posted 05/05/2020
    SGK (GSK650394 10 μM)
    GSK 650394 3572

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