GSK 650394

Catalog # Availability Size / Price Qty
3572/10
3572/50
GSK 650394 | CAS No. 890842-28-1 | Other Kinase Inhibitors
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Description: Serum- and glucocorticoid-regulated kinase (SGK) inhibitor

Chemical Name: 2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl-benzoic acid

Purity: ≥97%

Product Details
Citations (17)
Reviews

Biological Activity

Serum- and glucocorticoid-regulated kinase 1 (SGK1) inhibitor (IC50 values are 62 and 103 nM for SGK1 and SGK2 respectively). Displays >30-fold selectivity over Akt and other related kinases. Inhibits androgen-stimulated growth of LNCaP cells, a human prostate carcinoma cell line (IC50 ~ 1 μM).

Technical Data

M.Wt:
382.45
Formula:
C25H22N2O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥97%
Storage:
Store at RT
CAS No:
890842-28-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of GlaxoSmithKline

Product Datasheets

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Citations for GSK 650394

The citations listed below are publications that use Tocris products. Selected citations for GSK 650394 include:

17 Citations: Showing 1 - 10

  1. Osmotic induction of cyclooxygenase-2 in RPE cells: Stimulation of inflammasome activation.
    Authors: Messerschmidt Et al.
    Mol Vis  2019;25:329
  2. Activator protein-1 contributes to the NaCl-induced expression of VEGF and PlGF in RPE cells.
    Authors: Kleiner Et al.
    Mol Vis  2018;24:647
  3. Signaling Cascade Involved in Rapid Stimulation of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) by dexameth.
    Authors: Bossmann Et al.
    Int J Mol Sci  2017;18
  4. Role of SGK1 for fatty acid uptake, cell survival and radioresistance of NCI-H460 lung cancer cells exposed to acute or chronic cycling severe hypoxia.
    Authors: Matschke Et al.
    Radiat Oncol  2016;11:75
  5. Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion.
    Authors: Juvekar Et al.
    Proc Natl Acad Sci U S A  2016;113:E4338
  6. Phosphorylation on TRPV4 Serine 824 Regulates Interaction with STIM1.
    Authors: Shin Et al.
    Open Biochem J  2015;9:24
  7. SGK-1 protects kidney cells against apoptosis induced by ceramide and TNF-α.
    Authors: Pastore Et al.
    Oncotarget  2015;6:e1890
  8. A high-throughput kinome screen reveals serum/glucocorticoid-regulated kinase 1 as a therapeutic target for NF2-deficient meningiomas.
    Authors: Beauchamp Et al.
    J Biol Chem  2015;6:16981
  9. Excess salt exacerbates blood-brain barrier disruption via a p38/MAPK/SGK1-dependent pathway in permanent cerebral ischemia.
    Authors: Zhang Et al.
    Cell Death Dis  2015;5:16548
  10. Sodium chloride inhibits the suppressive function of FOXP3+ regulatory T cells.
    Authors: Hernandez Et al.
    J Neurosci  2015;125:4212

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