Selective, non-steroidal farnesoid X receptor (FXR) agonist (EC50
= 15 nM). Displays no activity at other nuclear receptors at concentrations up to 1 μ
M. Improves hyperglycaemia and hyperlipidemia in diabetic db/db mice. Shown to suppress autophagy in nutrient-deprived mouse hepatocytes.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Sold for research purposes under agreement from GlaxoSmithKline
Nutrient-sensing nuclear receptors coordinate autophagy.
Lee Jm, Wagner M, Xiao R et al.
Identification of a chemical tool for the orphan nuclear receptor FXR.
Maloney et al.
The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice.
Cariou et al.
Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice.
Zhang et al.
The citations listed below are publications that use Tocris products. Selected citations for GW 4064 include:
Showing Results 1 - 7 of 7