Catalog Number: 2473
Chemical Name: 3-[2-[2-Chloro-4-[[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]phenyl]ethenyl]benzoic acid
Biological Activity
Selective, non-steroidal farnesoid X receptor (FXR) agonist (EC50 = 15 nM). Displays no activity at other nuclear receptors at concentrations up to 1 μM. Improves hyperglycaemia and hyperlipidemia in diabetic db/db mice. Shown to suppress autophagy in nutrient-deprived mouse hepatocytes.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in ethanol
  • Purity:
  • Storage:
    Desiccate at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline
Background References
  1. Nutrient-sensing nuclear receptors coordinate autophagy.
    Lee Jm, Wagner M, Xiao R et al.
  2. Identification of a chemical tool for the orphan nuclear receptor FXR.
    Maloney et al.
    J.Med.Chem., 2000;43:2971
  3. The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice.
    Cariou et al.
    J.Biol.Chem., 2006;281:11039
  4. Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice.
    Zhang et al.
    Proc.Natl.Acad.Sci.USA, 2006;103:1006
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