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HA 1100 hydrochloride

2415 2 Citations Datasheet / COA / SDS
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2415/10
HA 1100 hydrochloride | CAS No. 155558-32-0 | Rho-kinase Inhibitors
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Description: Cell-permeable, selective Rho-kinase inhibitor
Alternative Names: Hydroxyfasudil

Chemical Name: 1-[(1,2-Dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepine hydrochloride

Purity: ≥99%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

HA 1100 hydrochloride is a cell-permeable active metabolite of Fasudil (HA 1077; Cat. No. 0541). Produces ATP-competitive and reversible inhibition of Rho-kinase and is ~ 100-fold selective over a range of other protein kinases. Inhibits neutrophil migration and produces potent vasodilatory effects in vivo.

Technical Data

M.Wt:
343.83
Formula:
C14H17N3O3S.HCl
Solubility:
Soluble to 20 mM in water
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
155558-32-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for HA 1100 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for HA 1100 hydrochloride include:

2 Citations: Showing 1 - 2

  1. Age-dependent contribution of Rho kinase in CB-induced contraction of human detrusor smooth muscle in vitro.
    Authors: Kirschstein Et al.
    Acta Pharmacol Sin  2014;35:74
  2. PropF. neurotoxicity is mediated by p75 neurotrophin receptor activation.
    Authors: Pearn Et al.
    Anesthesiology  2012;116:352

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