HA 1100 hydrochloride
Chemical Name: 1-[(1,2-Dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepine hydrochloride
Biological ActivityHA 1100 hydrochloride is a cell-permeable active metabolite of Fasudil (HA 1077; Cat. No. 0541). Produces ATP-competitive and reversible inhibition of Rho-kinase and is ~ 100-fold selective over a range of other protein kinases. Inhibits neutrophil migration and produces potent vasodilatory effects in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Inhibition by the protein kinase inhibitor HA1077 of the activation of NADPH oxidase in human neutrophils.
Arai et al.
Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm.
Shimokawa et al.
Antianginal effects of hydroxyfasudil, a Rho-kinase inhibitor, in a canine model of effort angina.
Utsunomiya et al.
Citations for HA 1100 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for HA 1100 hydrochloride include:
2 Citations: Showing 1 - 2
Age-dependent contribution of Rho kinase in CB-induced contraction of human detrusor smooth muscle in vitro.
Authors: Kirschstein Et al.
Acta Pharmacol Sin 2014;35:74
PropF. neurotoxicity is mediated by p75 neurotrophin receptor activation.
Authors: Pearn Et al.
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