HA 1100 hydrochloride
Chemical Name: 1-[(1,2-Dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepine hydrochloride
Purity: ≥99%
Biological Activity
HA 1100 hydrochloride is a cell-permeable active metabolite of Fasudil (HA 1077; Cat. No. 0541). Produces ATP-competitive and reversible inhibition of Rho-kinase and is ~ 100-fold selective over a range of other protein kinases. Inhibits neutrophil migration and produces potent vasodilatory effects in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Inhibition by the protein kinase inhibitor HA1077 of the activation of NADPH oxidase in human neutrophils.
Arai et al.
Biochem.Pharmacol., 1993;46:1487 -
Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm.
Shimokawa et al.
Cardiovasc.Res., 1999;43:1029 -
Antianginal effects of hydroxyfasudil, a Rho-kinase inhibitor, in a canine model of effort angina.
Utsunomiya et al.
Br.J.Pharmacol., 2001;134:1724
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