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HA 1100 hydrochloride

  ( 2 citations )    
Product Datasheet
Catalog Number:2415
Alternate Names:Hydroxyfasudil
Chemical Name:1-[(1,2-Dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepine hydrochloride
Product Details
Citations (2)
Reviews
Biological Activity
Cell-permeable active metabolite of Fasudil (HA 1077; Cat. No. 0541). Produces ATP-competitive and reversible inhibition of Rho-kinase and is ~ 100-fold selective over a range of other protein kinases. Inhibits neutrophil migration and produces potent vasodilatory effects in vivo.
Technical Data
  • M.Wt:
    343.83
  • Formula:
    C14H17N3O3S.HCl
  • Solubility:
    Soluble to 20 mM in water
  • Purity:
    >99
  • Storage:
    Store at -20°C
  • CAS No:
    155558-32-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for HA 1100 hydrochloride include:

2 Citations: Showing 1 - 2
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  1. Age-dependent contribution of Rho kinase in carbachol-induced contraction of human detrusor smooth muscle in vitro.
    Authors: Kirschstein Et al.
    Acta Pharmacol Sin  2014;35:74
  2. Propofol neurotoxicity is mediated by p75 neurotrophin receptor activation.
    Authors: Pearn Et al.
    Anesthesiology  2012;116:352

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