Catalog Number: 2415
Alternate Names: Hydroxyfasudil
Chemical Name: 1-[(1,2-Dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepine hydrochloride
Biological Activity
Cell-permeable active metabolite of Fasudil (HA 1077; Cat. No. 0541). Produces ATP-competitive and reversible inhibition of Rho-kinase and is ~ 100-fold selective over a range of other protein kinases. Inhibits neutrophil migration and produces potent vasodilatory effects in vivo.
Technical Data
  • M.Wt:
    343.83
  • Formula:
    C14H17N3O3S.HCl
  • Solubility:
    Soluble to 20 mM in water
  • Purity:
    >99%
  • Storage:
    Store at -20°C
  • CAS No:
    155558-32-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Inhibition by the protein kinase inhibitor HA1077 of the activation of NADPH oxidase in human neutrophils.
    Arai et al.
    Biochem.Pharmacol., 1993;46:1487
  2. Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm.
    Shimokawa et al.
    Cardiovasc.Res., 1999;43:1029
  3. Antianginal effects of hydroxyfasudil, a Rho-kinase inhibitor, in a canine model of effort angina.
    Utsunomiya et al.
    Br.J.Pharmacol., 2001;134:1724
Citations:

The citations listed below are publications that use Tocris products. Selected citations for HA 1100 hydrochloride include:

1 Citations: Showing 1 - 1

  1. Propofol neurotoxicity is mediated by p75 neurotrophin receptor activation.
    Authors: Pearn Et al.
    Anesthesiology 2012;116:352

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