HA 1100 hydrochloride

  ( 2 citations )    
Product Datasheet
Catalog Number:2415
Alternate Names:Hydroxyfasudil
Chemical Name:1-[(1,2-Dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepine hydrochloride
Product Details
Citations (2)
Reviews
Biological Activity
Cell-permeable active metabolite of Fasudil (HA 1077; Cat. No. 0541). Produces ATP-competitive and reversible inhibition of Rho-kinase and is ~ 100-fold selective over a range of other protein kinases. Inhibits neutrophil migration and produces potent vasodilatory effects in vivo.
Technical Data
  • M.Wt:
    343.83
  • Formula:
    C14H17N3O3S.HCl
  • Solubility:
    Soluble to 20 mM in water
  • Purity:
    >99
  • Storage:
    Store at -20°C
  • CAS No:
    155558-32-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for HA 1100 hydrochloride include:

2 Citations: Showing 1 - 2
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  1. Age-dependent contribution of Rho kinase in carbachol-induced contraction of human detrusor smooth muscle in vitro.
    Authors: Kirschstein Et al.
    Acta Pharmacol Sin  2014;35:74
  2. Propofol neurotoxicity is mediated by p75 neurotrophin receptor activation.
    Authors: Pearn Et al.
    Anesthesiology  2012;116:352

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