Proposed as the endogenous ligand for imidazoline binding sites. Binds to I1
-sites in rat kidney (IC50
= 31 nM) and I2
= 49 nM). Produces dose-dependent hypotension in vivo
that is reversed by efaroxan
(Cat. No. 0792). Potent inhibitor of monoamine oxidase A and B (IC50
values are 0.5 and 5 μ
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
β-Carbolines as selective monoamine oxidase inhibitors: in vivo implications.
Glover et al.
J.Neural Transm., 1982;54:209
The I1-imidazoline receptor and its cellular signalling pathways.
Ernsberger et al.
Harmane produces hypotension following microinjection into the RVLM: possible role of I1-imidazoline receptors.
Musgrave and Badoer
Harmane, norharmane and tetrahydro β-carboline have high affinity for rat imidazoline binding sites.
Hudson et al.