Chemical Name: 1-Methyl-9H-pyrido[3,4-b]indole
Biological ActivityProposed as the endogenous ligand for imidazoline binding sites. Binds to I1-sites in rat kidney (IC50 = 31 nM) and I2-sites (Ki = 49 nM). Produces dose-dependent hypotension in vivo that is reversed by efaroxan (Cat. No. 0792). Potent inhibitor of monoamine oxidase A and B (IC50 values are 0.5 and 5 μM respectively).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
The I1-imidazoline receptor and its cellular signalling pathways.
Ernsberger et al.
β-Carbolines as selective monoamine oxidase inhibitors: in vivo implications.
Glover et al.
J.Neural Transm., 1982;54:209
Harmane produces hypotension following microinjection into the RVLM: possible role of I1-imidazoline receptors.
Musgrave and Badoer
Harmane, norharmane and tetrahydro β-carboline have high affinity for rat imidazoline binding sites.
Hudson et al.
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