Catalog Number: 1132
Alternate Names: Harman
Chemical Name: 1-Methyl-9H-pyrido[3,4-b]indole
Biological Activity
Proposed as the endogenous ligand for imidazoline binding sites. Binds to I1-sites in rat kidney (IC50 = 31 nM) and I2-sites (Ki = 49 nM). Produces dose-dependent hypotension in vivo that is reversed by efaroxan (Cat. No. 0792). Potent inhibitor of monoamine oxidase A and B (IC50 values are 0.5 and 5 μM respectively).
Technical Data
  • M.Wt:
    182.22
  • Formula:
    C12H10N2
  • Solubility:
    Soluble to 10 mM in 1eq. HCl
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    486-84-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References

  1. Kishimoto T et al.
    Leucocyte Typing VI. Garland Publishing Inc. London.
  2. β-Carbolines as selective monoamine oxidase inhibitors: in vivo implications.
    Glover et al.
    J.Neural Transm., 1982;54:209
  3. The I1-imidazoline receptor and its cellular signalling pathways.
    Ernsberger et al.
    Ann.N.Y.Acad.Sci., 1999;881:35
  4. Harmane produces hypotension following microinjection into the RVLM: possible role of I1-imidazoline receptors.
    Musgrave and Badoer
    Br.J.Pharmacol., 2000;129:1057
  5. Harmane, norharmane and tetrahydro β-carboline have high affinity for rat imidazoline binding sites.
    Hudson et al.
    Br.J.Pharmacol., 1999;126:2P

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