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Harmane

Catalog #: 1132 Datasheet / COA / SDS

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1132 has been discontinued.
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Harmane | CAS No. 486-84-0 | Imidazoline Ligands
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Description: Putative endogenous imidazoline ligand. Also MAO inhibitor
Alternative Names: Harman

Chemical Name: 1-Methyl-9H-pyrido[3,4-b]indole

Purity: ≥99%

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Biological Activity

Harmane is a proposed as the endogenous ligand for imidazoline binding sites. Binds to I1-sites in rat kidney (IC50 = 31 nM) and I2-sites (Ki = 49 nM). Produces dose-dependent hypotension in vivo that is reversed by efaroxan (Cat. No. 0792). Potent inhibitor of monoamine oxidase A and B (IC50 values are 0.5 and 5 μM respectively).

Technical Data

M.Wt:
182.22
Formula:
C12H10N2
Solubility:
Soluble to 10 mM in 1eq. HCl
Purity:
≥99%
Storage:
Store at RT
CAS No:
486-84-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
    Fox JT, Sakamuru S, Huang R
    Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
  2. The I1-imidazoline receptor and its cellular signalling pathways.
    Ernsberger et al.
    Ann.N.Y.Acad.Sci., 1999;881:35
  3. β-Carbolines as selective monoamine oxidase inhibitors: in vivo implications.
    Glover et al.
    J.Neural Transm., 1982;54:209
  4. Harmane produces hypotension following microinjection into the RVLM: possible role of I1-imidazoline receptors.
    Musgrave and Badoer
    Br.J.Pharmacol., 2000;129:1057
  5. Harmane, norharmane and tetrahydro β-carboline have high affinity for rat imidazoline binding sites.
    Hudson et al.
    Br.J.Pharmacol., 1999;126:2P

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