Harmane

Catalog # Availability Size / Price Qty
1132/100
Harmane | CAS No. 486-84-0 | Imidazoline Ligands
1 Image
Description: Putative endogenous imidazoline ligand. Also MAO inhibitor
Alternative Names: Harman

Chemical Name: 1-Methyl-9H-pyrido[3,4-b]indole

Purity: ≥99%

Product Details
Reviews

Biological Activity

Proposed as the endogenous ligand for imidazoline binding sites. Binds to I1-sites in rat kidney (IC50 = 31 nM) and I2-sites (Ki = 49 nM). Produces dose-dependent hypotension in vivo that is reversed by efaroxan (Cat. No. 0792). Potent inhibitor of monoamine oxidase A and B (IC50 values are 0.5 and 5 μM respectively).

Technical Data

M.Wt:
182.22
Formula:
C12H10N2
Solubility:
Soluble to 10 mM in 1eq. HCl
Purity:
≥99%
Storage:
Store at RT
CAS No:
486-84-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. The I1-imidazoline receptor and its cellular signalling pathways.
    Ernsberger et al.
    Ann.N.Y.Acad.Sci., 1999;881:35
  2. β-Carbolines as selective monoamine oxidase inhibitors: in vivo implications.
    Glover et al.
    J.Neural Transm., 1982;54:209
  3. Harmane produces hypotension following microinjection into the RVLM: possible role of I1-imidazoline receptors.
    Musgrave and Badoer
    Br.J.Pharmacol., 2000;129:1057
  4. Harmane, norharmane and tetrahydro β-carboline have high affinity for rat imidazoline binding sites.
    Hudson et al.
    Br.J.Pharmacol., 1999;126:2P

Product Datasheets

or select another batch:
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for Harmane

There are currently no reviews for this product. Be the first to review Harmane and earn rewards!

Have you used Harmane?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.