Anti-inflammatory, antioxidant, antitumor and antiangiogenic agent. Blocks NF-κ
B activation by a variety of stimuli, including TNF and okadaic acid. Shown to scavenge superoxide and peroxyl radicals. Also inhibits a variety of inflammatory responses. Reverses cardiac hypertrophy in mice via SIRT3 activation.
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All Tocris products are intended for laboratory research use only.
Honokiol is a potent scavenger of superoxide and peroxyl radicals.
Dikalov et al.
Honokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-κB activation pathway.
Ahn et al.
Mol.Cancer Res., 2006;4:621
Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo.
Bai et al.
Anti-inflammatory effect of honokiol is mediated by PI3K/Akt pathway suppression.
Kim and Cho
Acta Pharmacol.Sinica, 2008;29:113
Pillai et al.