Catalog Number: 4590
Chemical Name: 5,3'-Diallyl-2,4'-dihydroxybiphenyl
Biological Activity
Anti-inflammatory, antioxidant, antitumor and antiangiogenic agent. Blocks NF-κB activation by a variety of stimuli, including TNF and okadaic acid. Shown to scavenge superoxide and peroxyl radicals. Also inhibits a variety of inflammatory responses. Reverses cardiac hypertrophy in mice via SIRT3 activation.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Honokiol is a potent scavenger of superoxide and peroxyl radicals.
    Dikalov et al.
    Biochem.Pharmacol., 2008;76:589
  2. Honokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-κB activation pathway.
    Ahn et al.
    Mol.Cancer Res., 2006;4:621
  3. Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo.
    Bai et al.
    J.Biol.Chem., 2003;278:35501
  4. Anti-inflammatory effect of honokiol is mediated by PI3K/Akt pathway suppression.
    Kim and Cho
    Acta Pharmacol.Sinica, 2008;29:113

  5. Pillai et al.
    Nat.Commun., 2015;6:6656

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