Human BMP-2/BMP-4 Antibody

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Product Details
Citations (4)
Supplemental Products
Reviews (1)

Human BMP-2/BMP-4 Antibody Summary

Species Reactivity
Detects BMP-2 and BMP-4 in direct ELISAs and Western blots.
Polyclonal Goat IgG
Antigen Affinity-purified
Chinese hamster ovary cell line CHO-derived recombinant human BMP-2
Accession # P12643
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.


Recommended Concentration
Western Blot
0.1 µg/mL
Recombinant Human BMP‑2 (Catalog # 355-BEC)
Recombinant Human BMP‑4 (Catalog # 314-BP)
5-15 µg/mL
Immersion fixed human BMP-2 transfected cells

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

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Preparation and Storage

Reconstitute at 0.2 mg/mL in sterile PBS.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Size / Price
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: BMP-2/BMP-4

Human BMP-2 is one of at least 15 structurally and functionally related BMPs, which are members of the transforming growth factor  beta (TGF-beta ) superfamily. BMPs were originally identified as protein regulators of cartilage and bone formation. However, they have since been shown to be involved in embryogenesis and morphogenesis of various tissues and organs. BMPs have also been shown to regulate the growth, differentiation, chemotaxis and apoptosis of various cell types, including mesenchymal cells, epithelial cells, hematopoietic cells and neuronal cells. Similarly to other TGF-beta family proteins, BMPs are highly conserved across animal species. At the amino acid sequence level, mature human, mouse and rat BMP-2 are 100% identical. BMP-2 is synthesized as a large precursor protein that is cleaved at the dibasic cleavage site (RXXR) to release the carboxy-terminal domain. Biologically active BMP-2 is a disulfide-linked homodimer of the carboxy-terminal 114 amino acid residues that contains the characteristic seven conserved cysteine residues involved in the formation of the cysteine knot and the single interchain disulfide bond. Cellular responses to BMP-2 have been shown to be mediated by the formation of hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors. One BMP type II and two BMP type I receptors have been identified. In contrast to the TGF-beta type I receptor, which does not bind the ligand in the absence of the TGF-beta receptor type II, both BMP receptor type Is can bind BMP-2 with high-affinity in the absence of BMP receptor type II. 

  1. Kawabata, M. et al. (1998) Cytokine and Growth Factor Reviews 9:49
  2. Ebendal, T. et al. (1998) J. Neurosci. Res. 51:139.
  3. Reddi, A.H. (1998) Nature Biotechnology 16: 247.
Long Name
Bone Morphogenetic Protein 2/4
Entrez Gene IDs
650 (Human); 12156 (Mouse); 29373 (Rat)
Alternate Names
BDA2; BMP-2; BMP-2/BMP-4; BMP2A; BMP-2A; BMP2ABone morphogenetic protein 2A; bone morphogenetic protein 2

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Citations for Human BMP-2/BMP-4 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

4 Citations: Showing 1 - 4
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  1. Selective endocytosis of recombinant human BMPs through cell surface heparan sulfate proteoglycans in CHO cells: BMP-2 and BMP-7
    Authors: MG Kim, CL Kim, YS Kim, JW Jang, GM Lee
    Scientific Reports, 2021;11(1):3378.
    Species: Hamster
    Sample Types: Whole Cells
    Applications: ICC
  2. Amlodipine accelerates bone healing in a stable closed femoral fracture model in mice
    Authors: MM Menger, B Merscher, C Scheuer, BJ Braun, SC Herath, MF Rollmann, D Stenger, T Später, T Pohlemann, MD Menger, T Histing
    European cells & materials, 2021;41(0):592-602.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  3. The effect of host tissue irradiation on large-segment allograft incorporation.
    Authors: Ehrhart NP, Eurell JA, Constable PD, Gaddy D, Nicholas RW
    Clin. Orthop. Relat. Res., 2005;0(435):43-51.
    Species: Canine
    Sample Types: Whole Tissue
    Applications: IHC-P
  4. HOXA13 regulates the expression of bone morphogenetic proteins 2 and 7 to control distal limb morphogenesis.
    Authors: Knosp WM, Scott V, Bachinger HP, Stadler HS
    Development, 2004;131(18):4581-92.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC


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Isotype Controls

Reconstitution Buffers

Secondary Antibodies

Goat IgG (H+L) Antibody


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Human BMP-2/BMP-4 Antibody
By Anonymous on 11/29/2020
Application: Func Sample Tested: Plasma Species: Human