Human BMP-2/BMP-7 Heterodimer Alexa Fluor® 488-conjugated Antibody

Catalog #: FAB3229G Datasheet / COA / SDS

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FAB3229G-100UG

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Human BMP-2/BMP-7 Heterodimer Alexa Fluor® 488-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human BMP‑2/BMP‑7 Heterodimer in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 5% cross‑reactivity with recombinant human (rh) BMP-2 is observed, and no cross-reactivity with rhBMP-4/7, -4, -5, -6, -7, or -8 i

Source

Monoclonal Mouse IgG1 Clone # 369505

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human BMPâ€‘2/BMPâ€‘7 Heterodimer
Ala284-Arg396 (BMP-2), Ser293-His431 (BMP-7)
Accession # NP_001191, NP_001710

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 488 (Excitation= 488 nm, Emission= 515-545 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: BMP-2

Bone Morphgenetic Protein 7 (BMP-7), also known as osteogenic protein 1 (OP-1), and BMP-2 are members of the BMP subgroup of the TGF-beta superfamily and signal through heterodimeric complexes composed of type I and type II BMP receptors. After proteolytic removal of their propeptides, BMP-2 and BMP-7 can associate into 38 kDa disulfide-linked heterodimers. The heterodimers are significantly more potent than either homodimer in osteoblast differentiation and bone formation assays. Human and mouse BMP-2 and BMP-7 share 100% and 98% aa sequence identity, respectively.

Long Name

Bone Morphogenetic Protein 2

Entrez Gene IDs

650 (Human); 12156 (Mouse); 29373 (Rat)

Alternate Names

BDA2; BMP2; BMP-2; BMP-2A; BMP2ABone morphogenetic protein 2A; bone morphogenetic protein 2; SSFSC